A5083348735- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Chemical Synthesis and Analysis
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Advanced Materials and Mechanics
- Cardiac Valve Diseases and Treatments
- Silk-based biomaterials and applications
- Electrohydrodynamics and Fluid Dynamics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical sensors and biosensors
- Click Chemistry and Applications
- Scientific and Engineering Research Topics
- Virus-based gene therapy research
- Advanced Sensor and Energy Harvesting Materials
- Synthetic Organic Chemistry Methods
- Connective tissue disorders research
- Nanomaterials and Printing Technologies
- Neuroscience and Neural Engineering
- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Synthesis and Biological Evaluation
- Advanced Nanomaterials in Catalysis
California NanoSystems Institute
2018-2021
University of California, Los Angeles
2018-2021
Brigham and Women's Hospital
2015-2018
Harvard University
2015-2018
Harvard–MIT Division of Health Sciences and Technology
2015-2018
Massachusetts Institute of Technology
2015-2018
Innovation Research Center
2015-2018
Samueli Institute
2018
University of Florida
2013-2014
Bioprinting is the most convenient microfabrication method to create biomimetic three‐dimensional (3D) cardiac tissue constructs, that can be used regenerate damaged and provide platforms for drug screening. However, existing bioinks, which are usually composed of polymeric biomaterials, poorly conductive delay efficient electrical coupling between adjacent cells. To solve this problem, a gold nanorod (GNR)‐incorporated gelatin methacryloyl (GelMA)‐based bioink developed printing 3D...
Abstract Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal generally by using membrane. The main role of these membranes to establish mechanical barrier that prevents the apical migration gingival epithelium and hence allowing growth ligament bone selectively repopulate root surface. Currently available have limited bioactivity potential. To address...
Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities pristine polymers. The majority of studies focused on incorporation spherical nanoparticles within fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) into fibrous scaffolds fabricated by electrospinning. addition branched particles resulted in their protrusion from fibers, mimicking architecture a rose stem. We demonstrated that...
Chaotic flows are used to rapidly fabricate densely packed lamellar micro- and nanostructure that is then preserved by curing or photocrosslinking.
Growth-factor-free bone regeneration remains a challenge in craniofacial engineering. Here, we engineered an osteogenic niche composed of commercially modified alginate hydrogel and whitlockite microparticles (WHMPs), which impart tunable physicochemical properties that can direct osteogenesis human gingival mesenchymal stem cells (GMSCs). Our vitro studies demonstrate WHMPs induce GMSCs more effectively than previously demonstrated hydroxyapatite (HApMPs). Alginate–WHMP hydrogels showed...
Liquid-crystal-based biomaterials provide promising platforms for the development of dynamic and responsive interfaces tissue engineering. Cholesteryl ester liquid crystals (CLCs) are particularly well suited these applications, due to their roles in cellular homeostasis intrinsic ability organize into supramolecular helicoidal structures on mesoscale. Here, we developed a nonwoven CLC electrospun scaffold by dispersing three cholesteryl ester-based mesogens within polycaprolactone (PCL). We...
Abstract Dimerization–macrocyclization has been a long‐standing problem in the cyclization of peptides since, together with desired cyclic product, many oligomers and linear polymers may also be formed during reaction. Therefore, development process that affords dimer predominantly is difficult. A novel versatile strategy for synthesis symmetric cyclo ‐tetrapeptides by palladium‐promoted tandem deprotection/cyclo‐dimerization from readily available Cbz‐dipeptidoyl benzotriazolides reported...
Open-chain N-Cbz-protected-peptidoyl benzotriazolides are converted by a novel lactamization strategy using proline as turn introducer into both symmetrical (5a–c and 11a–c) unsymmetrical (19a–e) bis-2,5-diketopiperazines (bis-2,5-DKPs), previously recognized difficult targets.
In article 1703437, Alireza Moshaverinia, Ali Tamayol, and co-workers develop a nano-enabled membrane for the treatment of periodontitis-induced bone loss. The membranes are formed by electrospinning poly(caprolactone) containing zinc oxide nanoparticles. outcome fabrication process nanofibrous embedded with ZnO prevent infection direct tissue regeneration in vivo.
Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite polycaprolactone (PCL) polymer dispersion anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production hydrogen peroxide for an accessible disinfection sterilizing...
A novel conductive bioink containing dispersed gold nanoparticles in a photocrosslinkable hydrogel matrix is developed for microfluidic bioprinting of cardiomyocyteladen microfibrous scaffolds. As described by Su Ryon Shin, Ali Khademhosseini, and co-workers article number 1605352, increased conductivity the leads to improved functionality cardiomyocytes bioprinted patches, enabling potential applications cardiac tissue engineering.
Micromaterials can be fabricated in a near infinite number of shapes, sizes, and chemical compositions. These micromaterials subsequently assembled into macro-sized constructs using bottom-up approaches as reviewed by A. Khademhosseini co-workers on page 2130. Each type micromaterial provide unique micro-environment to the (stem) cells. This leveraged drive e.g., angiogenesis, neurogenesis, or osteogenesis spatially preprogrammed manner allow formation organized bioengineered tissues.
We employed the large surface-to-volume ratio of nanoporous gold (NPG) to build a set highly sensitive superoxide electrochemical biosensors. Once functionalized with cytochrome-c (cyt-c) NPG-based electrodes displayed sensitivity 0.24 nA nM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and low-level detection 5 towards superoxide. The planar were then interfaced HUVEC cells able detect release extracellular upon stimulation an...