A5033769284- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Vascular anomalies and interventions
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Infective Endocarditis Diagnosis and Management
- Neuropeptides and Animal Physiology
- Vascular Anomalies and Treatments
- Pharmaceutical studies and practices
- Cardiovascular Issues in Pregnancy
- Asthma and respiratory diseases
- Trauma Management and Diagnosis
Deutsches Herzzentrum München
2020-2025
Technical University of Munich
2020-2025
Abstract OBJECTIVES We aimed to determine the incidence of postoperative complete atrioventricular block, time recovery or permanent pacemaker implantation, and predictors for block after congenital heart surgery. METHODS Patients who underwent open surgery from January 2001 2024 were analyzed identified using a logistic regression model. RESULTS Among 9765 surgeries, 333 (3.4%) complicated by 193 patients (1.9%) implantation. The highest rates found in repair congenitally corrected...
This study investigated the longitudinal changes in ventricular function and atrioventricular valve to clarify timing mechanisms of failing Fontan. Patients who underwent total cavopulmonary connection between 1994 2023 were reviewed, echocardiographic examinations regurgitation analysed. A 650 patients included. The most frequent primary diagnosis was hypoplastic left heart syndrome 175 patients. Dominant right ventricle observed 337 (51.8%). median age at 2.3 (1.8-3.3) years. Failing...
This study aimed to evaluate the relationship between pulmonary artery size and venovenous collaterals during staged single ventricle reconstruction. Patients who underwent Fontan palliation 2003 2023 were reviewed. The index development of was determined. Furthermore, impact on in-hospital morbidities after procedure evaluated. A total 377 patients included. Median age at bidirectional cavopulmonary shunt connection 4.2 (3.3-6.2) months 2.1 (1.7-2.6) years, respectively. Venovenous observed...
Abstract Background NT-proBNP is one of the most important biomarkers for diagnosis and risk assessment heart failure in adults. Age- gender-independent reference intervals (RIs) have been reported. In contrast, RIs children are strongly age-dependent, do not exist all ages reveal a right-skewed distribution. Accordingly, no common Z-score can be formed cross-age interpretive method, so far, missing. Methods Within paper on hand, new evaluation techniques applied to already published study...
Children with univentricular hearts (UVH) undergo up to three palliative surgical procedures achieve complete circulatory separation (Fontan circulation). As a marker of cardiac wall stress, NT-proBNP is promising tool assess systemic ventricular load in these patients. However, different reference intervals (RI) apply each stage, as highly age-dependent.
This study aimed to evaluate veno-venous collaterals between bidirectional cavopulmonary shunt and total connection. Patients who underwent staged connection 1995 2022 were reviewed. Veno-venous depicted using angiograms. The prevalence of collaterals, the risks for development impact on outcomes analysed. In total, 586 patients included. found in 72 (12.3%) patients. Majority originated from superior caval vein drained into inferior vein. Before shunt, mean pulmonary artery pressure (16.3...
Abstract Background: Due to the high postoperative mortality, tools for an adaequate risk stratification are important identify high-risk patients undergoing Norwood procedure. As a marker of ventricular wall stress, NT-proBNP might be particular interest in these children. Objectives: This study evaluated whether NT-proBNP’s age-adjusted z-score (“zlog-NT-proBNP”) predicts outcomes after stage I Methods: Patients who underwent procedure between 1 January 2011 and 31 December 2022, with...
We aimed to evaluate outcomes after Kawashima procedure with special regard the development of pulmonary arterio-venous malformations. All patients who underwent between 1992 and 2022 were reviewed. Twenty-one at a median age 14.5 (interquartile range, 8.4-40.4) months. There no hospital deaths 2 late deaths. Survival 5, 10, 15 years was 90.5, 82.9, 69.1%, respectively. It 100% 10 for children 9 months old or younger procedure, compared 77.0% older (p = 0.281). Hepatic vein incorporation...
This study aimed to investigate the incidence of diaphragm paralysis and its impact on outcomes after Fontan procedure in patients with single ventricles. Patients undergoing staged palliation between 1994 2023 were reviewed. who had identified completion was evaluated. Among 601 underwent during period, observed 79 (13.1%) before (33 stage I 46 Glenn) 32 (5.3%) Fontan. 111 paralysis, 77 spontaneous recovery, 13 recovered plication, 21 remained without recovery. demonstrated higher pulmonary...
Abstract OBJECTIVES Biventricular repair for patients with borderline hypoplastic left ventricle is challenging, and a predictor of failing biventricular has not been clarified. This study aimed to analyze the z-log N-terminal pro-B-type natriuretic peptide evaluate its usefulness in predicting outcomes after repair. METHODS Patients who were diagnosed heart hypoplasia underwent from 2012 2022 included. Serial values evaluated using age-adjusted z-score. The data was collected first...
This study aimed to investigate the benefits and potential risks of implantable cardioverter-defibrillators in pediatric congenital heart disease patients current era. All with disease, cardiomyopathy, or primary electrical who underwent implantation a defibrillator from 2001 2023 were examined. The occurrence appropriate therapy, unplanned surgeries due device complications, inappropriate shocks, associated risk factors analyzed. A total 214 included, 61% having 17% 22% disease. most common...
Abstract Objective This study aimed to investigate the impact of left pulmonary artery stenting on outcomes after Fontan procedure in patients with single ventricle physiology. Methods Patients who underwent staged palliation between 1994 and 2023 were reviewed. The records had stents implanted analyzed, their completion was evaluated. Results Among 601 during period, 64 (10.6%) a stent (19 before Glenn 49 Fontan). exhibited higher arterial pressure (10 vs. 9 mmHg, p = 0.005) smaller...
Abstract Objective: Current research suggests that a small pulmonary artery can cause adverse events and reduce exercise capacity after the Fontan procedure. This study aimed to evaluate impact of size on early haemodynamic laboratory variables total cavopulmonary connection. Methods: We reviewed all patients who underwent staged between 2012 2022. Pulmonary index before bidirectional shunt connection was calculated according Nakata colleagues. sought analyse variables, including pressure...
Abstract Objective In this study, we aimed to compare the outcome after Fontan procedure in patients an initial ductus stenting or a surgical aortopulmonary shunt. Methods We reviewed infants with single ventricle and ductal-dependent pulmonary blood flow who underwent shunt between 2009 2022, subsequently staged procedure. Results A total of 93 were included (39 54 shunts). Before procedure, artery pressure (9 vs. 9 mmHg, p = 0.376) index (184 183 mm2/m2, 0.988) similar groups. However,...
Abstract OBJECTIVES Acute kidney injury commonly complicates congenital heart surgery with cardiopulmonary bypass, increasing morbidity and mortality. This study aimed to evaluate risk factors for postoperative acute its impact on outcomes after the Norwood procedure. METHODS Neonates undergoing procedure from 2001 2022 were reviewed. Using modified neonatal Kidney Disease Improving Global Outcomes criteria, we assessed analyzed survival. RESULTS Among 355 patients who included, severe...
As a marker of cardiac wall stress, NT-proBNP offers high prognostic and diagnostic potential in patients with functional single ventricle (fSV). Its levels depend on both age stage palliation. However, the impact systemic ventricular morphology this biomarker remains unclear. Children undergoing staged palliation, i.e. systemic-to-pulmonary shunt (SPS), ductal stenting (DS) and/or pulmonary artery banding (PAB) as 1, bidirectional cavopulmonary (BCPS) 2 or extracardiac total connection...
Abstract Background: Failing Fontan poses a significant clinical challenge. This study aims to improve patients’ outcomes by comprehensively understanding the incidence, pathophysiology, risk factors, and treatment of failing after total cavopulmonary connection. Methods: We performed retrospective analysis patients who underwent connection at German Heart Center Munich between 1994 2022. The onset was defined as: protein-losing enteropathy, plastic bronchitis, NYHA class IV, III for >...