A5000553800- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Pickering emulsions and particle stabilization
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Membrane Separation Technologies
- Peptidase Inhibition and Analysis
- Lipid Membrane Structure and Behavior
- Algal biology and biofuel production
- Extracellular vesicles in disease
- Antimicrobial agents and applications
- Radiomics and Machine Learning in Medical Imaging
- Polymer Surface Interaction Studies
- Radiopharmaceutical Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diatoms and Algae Research
- Nanoparticles: synthesis and applications
- Nanopore and Nanochannel Transport Studies
- Nuclear Structure and Function
- Advanced Nanomaterials in Catalysis
University of Basel
2021-2024
FORS – Swiss Centre of Expertise in the Social Sciences
2024
One of the key aspects coping efficiently with complex pathological conditions is delivering desired therapeutic compounds precision in both space and time. Therefore, focus on nuclear-targeted delivery systems has emerged as a promising strategy high potential, particularly gene therapy cancer treatment. Here, we explore design supramolecular nanoassemblies vehicles to deliver specific nucleus, special polymer peptide-based carriers that expose nuclear localization signals. Such aim at...
Artificial organelles (AnOs) are in the spotlight as systems to supplement biochemical pathways cells. While polymersome-based artificial containing enzymes reduce reactive oxygen species (ROS) known, applications requiring control of their enzymatic activity and cell-targeting promote intracellular ROS detoxification underexplored. Here, we introduce advanced AnOs where chemical composition membrane supports insertion pore-forming melittin, enabling molecular exchange between AnO cavity...
Antibacterial surfaces can be classified into two categories: passive surfaces, which repel bacteria by affecting surface wettability, and active have bactericidal properties that disrupt cell membranes upon contact. With the increasing demand for effective antibacterial solutions combine these properties, advanced strategies are concentrating on developing with dual antimicrobial functionalities. Here, we present nanotexture resulting from phase separation of different amphiphilic block...
The combination of "hard", structurally well-defined particles with "soft", functional compartments bears great potential to produce intricate hybrid nanomaterials that promote a multitude applications require multimodal agents and permit the production molecular factories. However, co-assembly "hard" "soft" components in programmable directional manner is challenging due strongly differing mechanical properties such disparate entities. Here, versatile strategy generate clusters by...
As current chemo- and photodynamic cancer therapies are associated with severe side effects due to a lack of specificity systemic toxicity, innovative solutions in terms targeting controlled functionality high demand. Here, we present the development polymersome nanocarrier equipped molecules loaded photosensitizers for efficient uptake light-activated cell killing. Polymersomes were self-assembled presence from mixture nonfunctionalized functionalized PDMS-b-PMOXA diblock copolymers, latter...
Combination therapies demand co-delivery platforms with efficient entrapment of distinct payloads and specific delivery to cells possibly organelles. Herein, we introduce the combination two therapeutic modalities, gene photodynamic therapy, in a purely peptidic platform. The simultaneous formation cargo loading multi-micellar platform is governed by self-assembly at nanoscale. architecture nanocarrier positive charge its constituent micelles offer controlled dual capacity locations for...
DNA-loaded peptidic platform entering the cell and delivering its payloads to nucleus.
Abstract Gaining insight into the complex functions of tissues, which involve communicating cell types, by utilizing materials that mimic properties real tissue, is an important step in developing advanced biomedical applications. However, building 3D networks interconnected protocells capable chemical information processing and collective output remains a challenge. Herein, construction prototissue based on DNA‐mediated assembly polymeric giant unilamellar vesicles (pGUVs) are presented...
Cell-derived vesicles retain the cytoplasm and much of native cell membrane composition. Therefore, they are attractive for investigations biophysics, drug delivery systems, complex molecular factories. However, their fragility aggregation limit applications. Here, mechanical properties stability giant plasma (GPMVs) enhanced by decorating them with a specifically designed diblock copolymer, cholesteryl-poly[2-aminoethyl methacrylate-b-poly(ethylene glycol) methyl ether acrylate]. When...
Abstract Aberrant activation of epidermal growth factor receptor (EGFR) signaling pathways is associated with tumor and progression. EGFR overexpression occurs in various types solid cancers correlates poor outcome. Unfortunately, the clinical benefit from EGFR-targeted therapies usually short-lived, due to development resistance. TargImmune has developed first-in-class Targeted Apoptotic Immunomodulators (TAIMs), which harness body’s anti-viral responses treat tumors. Our novel nanoparticle...