About
Contact & Profiles
A5064371677
Research Areas
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Drug Transport and Resistance Mechanisms
National Cheng Kung University
2021
Abstract Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause tumor genomic instability cancer stemness, but also increased levels ATP-binding cassette (ABC) transporters P-gp, ABCG2, ezrin enhance pumping out Taxol from cells, thus resulted drug during therapy. A novel inhibitor, NCI677397, was screened for...
10.1038/s41418-021-00778-z
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Cell Death and Differentiation
2021-04-12
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