A5065778850- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Healthcare and Venom Research
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Endoplasmic Reticulum Stress and Disease
- Scoliosis diagnosis and treatment
- Pregnancy-related medical research
- Nerve injury and regeneration
- Inflammasome and immune disorders
- Management of metastatic bone disease
- Electrospun Nanofibers in Biomedical Applications
- Bone and Joint Diseases
- Pain Mechanisms and Treatments
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
Zhongda Hospital Southeast University
2015-2024
Southeast University
2013-2024
Northern Jiangsu People's Hospital
2022-2023
Southeast University
2022
Jiangnan University
2020-2022
Marymount University
2020
Xiaomi (China)
2018
Texas A&M University
1999
A retrospective review involving 873 consecutive cases of lumbar disc herniation treated by microendoscopic discectomy (MED) was conducted and a mean 28-month follow-up performed.The purpose this study to describe the MED technique for report long-time outcome complications.The conception introduced in 1997. Long-time has not been described.A total patients with were METRx system. Oswestry Disability Index (ODI) used quantify pain relief. The degree disability also measured visual analog...
Resveratrol (RSV) is known to play a role of anti-TNF-α in number cell types. However, whether RSV modulates the effects TNF-α on human nucleus pulposus (NP) cells unknown. The purpose this study investigate regulates TNF-α-induced matrix metalloproteinase-3 (MMP-3) expression. Via quantitative real-time polymerase chain reaction (qRT-PCR) analysis, we found that MMP-3 expression induced by was inhibited treatment. Depending Western blot and qRT-PCR assay, autophagy NP cells, whereas...
Background Methods for grading and localization of lumbar disc herniation (LDH) on MRI are complex, time‐consuming, subjective. Utilizing deep learning (DL) models as assistance would mitigate such complexities. Purpose To develop an interpretable DL model capable localizing LDH. Study Type Retrospective. Subjects 1496 patients (M/F: 783/713) were evaluated, randomly divided into training (70%), validation (10%), test (20%) sets. Field Strength/Sequence 1.5T axial T2‐weighted sequences (spin...
Study Design Retrospective, case control evaluation of 86 patients who underwent microendoscopic discectomy (MED) and percutaneous transforaminal endoscopic (PTED) for the treatment lumbar disc herniation (LDH). Purpose To evaluate safety outcomes MED PTED LDH. Overview Literature are minimally invasive surgical techniques lower back pain. Studies to date have shown that safe effective modalities Methods A retrospective study was performed in with LDH treated (n=50) (PTED; n=36) our...
The reported date in the repeat surgical intervention for adolescent lumbar disc herniation (ALDH) after percutaneous endoscopic discectomy (PELD) was quite scarce. This study aims to introduce cases of surgeries PELD ALDH and assess incidence, chief causes, surgery methods, outcomes ALDH.
Abstract Background Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points chondrocyte senescence as a key driver in OA development. This study aims identify OA-specific microRNAs (miRNAs) targeting alleviate progression. Methods We screened and identified miRNAs differentially expressed normal cartilage, then confirmed impact miR-653-5p on functions phenotypes through vitro experiments with...
Although tumor necrosis factor alpha (TNF-α) is known to play a critical role in intervertebral disc (IVD) degeneration, the effect of TNF-α on nucleus pulposus (NP) cells has not yet been elucidated. The aim this study was explore proliferation human NP cells. were treated with different concentrations TNF-α. Cell determined by cell counting kit-8 (CCK-8) analysis and Ki67 immunofluorescence staining, expression cyclin B1 studied quantitative real-time RT-PCR. cycle measured flow cytometry...
Inflammation is thought to have a major role in the pathogenesis of disc degeneration. Studies shown that nucleus pulposus cells (NPCs) respond one or two specific cytokines by regulating cell proliferation matrix synthesis. However, effects cocktail factors secreted degenerated on transplanted exogenous healthy NPCs remain unknown. Concentrations multiple tissue-conditioned medium (dCM) were measured using enzyme-linked immunosorbent assay (ELISA). 3-(4, 5-Dimethylthiazol-2-yl)-2,...
In the degenerated intervertebral disc (IVD), matrix acidity challenges transplanted bone marrow mesenchymal stem cells (BMSCs). The Ca2+-permeable acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-mediated tissue injury. aim of our study was to confirm whether ASIC1a activation induces BMSC apoptosis under conditions that mimic acidic microenvironment IVD.ASIC1a expression in rat BMSCs investigated by real time-PCR, Western blot (WB) and immunofluorescence. proliferation were...
This cohort study aimed to elucidate early surgical outcomes after midline lumbar fusion (MidLIF) with cortical bone trajectory (CBT) screw fixation compared transforaminal interbody (TLIF) using traditional pedicle (TPS) for degenerative disease (LDD) in patients osteoporosis. The authors randomly assigned 70 osteoporosis who had LDD at 1 or 2 adjacent vertebral levels undergo either MidLIF CBT (CBT group) TLIF TPS (TPS from February 2015 March 2016. Pre- and postoperative Japanese...
Retrospective, matched case-control study.