A5103161658- Spine and Intervertebral Disc Pathology
- Inflammasome and immune disorders
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Spinal Hematomas and Complications
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Curcumin's Biomedical Applications
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- NF-κB Signaling Pathways
- Healthcare and Venom Research
- Immune Response and Inflammation
- interferon and immune responses
- Shoulder Injury and Treatment
- Gout, Hyperuricemia, Uric Acid
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Management of metastatic bone disease
- Periodontal Regeneration and Treatments
- ATP Synthase and ATPases Research
- Mechanical Engineering and Vibrations Research
- Spinal Cord Injury Research
- Streptococcal Infections and Treatments
- Pregnancy-related medical research
Zhongda Hospital Southeast University
2021-2024
Southeast University
2020-2022
Tongji University
2010
Baylor College of Medicine
1989
Signal transducing guanine nucleotide binding (G) proteins are heterotrimers with different α subunits that confer specificity for interactions receptors and effectors. Eight to ten such G couple a large number of hormones neurotransmitters at least eight Although one protein can interact several receptors, given was thought but effector. The recent finding voltage-gated calcium channels stimulated by purified s , which stimulates adenylyl cyclase, challenged this concept. However, may have...
Evidence has shown that effects from inflammation and mitochondrial dysfunction lead to pyroptosis apoptosis of nucleus pulposus (NP) cells. Damaged mitochondria release dangerous molecules such as reactive oxygen species (ROS), activating the NLRP3 inflammasome. SS-31 is a mitochondria-targeting peptide been used in treatment many diseases by scavenging ROS ameliorating function. This study found ameliorated lipopolysaccharide (LPS)-induced loss cell viability, production, NP Moreover,...
Targeting cellular senescence and associated secretory phenotype (SASP) through autophagy has emerged as a promising intervertebral disc (IVD) degeneration (IDD) treatment strategy in recent years. This study aimed to clarify the role mechanism of preventing IVD SASP. Methods involved vitro experiments with nucleus pulposus (NP) tissues from normal IDD patients, well an vivo animal model. GATA4's regulatory SASP was validated both vivo, while modulators were employed assess their impact on...
The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120) binds to cell surface receptors and mediates HIV entry. Previous studies suggest the protein disulfide isomerase (PDI) might interact with bond(s) of gp120 thus facilitate HIV-1 In present study, a kinetic trapping approach was used capture cross-linking intermediate between PDI. Active site mutant PDIs were prepared in which C-terminal cysteine at active replaced by serine. able covalently cross-link through mixed...
This study investigates the clinical efficacy and safety of percutaneous endoscopic nucleotomy combined with platelet-rich plasma (PRP) injection in treating lumbar disc herniation (LDH) young middle-aged adults.
Increasing evidence has shown that noncoding RNAs perform a remarkable function in neuropathic pain (NP); nonetheless, the mechanisms underlying modulation of competitive endogenous RNA NP remain uncertain. The goal this research was to investigate molecular processes NP. We utilized Gene Expression Omnibus (GEO) obtain NP-related microarray datasets included expression patterns circular (circRNAs) and messenger (mRNAs). Following that, bioinformatics analyses biology experiment were carried...
Abstract Background: More and more evidences show that non-coding RNAs are involved in neuropathic pain, however, there few reports on the regulatory mechanism of competitive endogenous RNA (ceRNA) pain. The purpose this study is to explore possible molecular mechanisms Methods: We collected pain-related microarray datasets providing expression profile circular (circRNAs) mRNAs from Gene Expression Omnibus (GEO) then performed bioinformatics analysis them. Results: present has identified...