A5076944691- Synthesis of Indole Derivatives
- Chemical Synthesis and Reactions
- Bioactive Compounds and Antitumor Agents
- Fluorine in Organic Chemistry
- Synthesis of heterocyclic compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Mesoporous Materials and Catalysis
- Synthesis and Catalytic Reactions
- Enzyme Catalysis and Immobilization
- Molecular Sensors and Ion Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Luminescence and Fluorescent Materials
- biodegradable polymer synthesis and properties
- Cyclization and Aryne Chemistry
- Various Chemistry Research Topics
- Polyoxometalates: Synthesis and Applications
- Microbial Metabolic Engineering and Bioproduction
- Molecular spectroscopy and chirality
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
University of Coimbra
2014-2024
University of Algarve
2008-2015
A successful one-pot methodology for the synthesis of chiral 2-tetrazolyl-2H-azirines has been established, resorting to organocatalysis. The protocol involves in situ tosylation β-ketoxime-1H-tetrazoles followed by Neber reaction, presence organocatalysts. Among organocatalysts studied a novel thiourea catalyst derived from 6β-aminopenicillanic acid afforded excellent enantioselectivities.
Regioselectivity in hetero Diels–Alder reactions can be observed a simple reaction between nonsymmetrical heterodiene and an unsymmetrical heterodienophile. A 9 h easy to implement laboratory experiment is described, which students observe the regioselectivity of inverse "electron-demand" azoalkene with furan or 2,3-dihydrofuran acting as dienophile. This combines synthesis, structural analysis (IR spectroscopy NMR spectroscopy), dry- vacuum-flash isolation methods.
A new and versatile synthetic approach towards bis(pyrazolyl)methanes, based on 1,4-addition of pyrazoles to conjugated α-halogenated nitroso- azoalkenes, is described. Tris(pyrazolyl)methanes can also be obtained by this methodology.
A one-pot regio- and stereoselective synthesis of a dipyrromethane bis(indolyl)methane based on two consecutive reactions nitrosoalkenes with pyrrole or indole, respectively, is described as an experiment to be carried out by upper-division undergraduate students in laboratory classroom. Importantly, the ability electrophilic conjugated react via Michael addition hetero-Diels–Alder electron-rich heterocycles will provide opportunity for acknowledge alternative reaction pathways underlying...
A new selective synthetic approach to indole derivatives bearing a tetrazole moiety has been developed. Arynes, generated in situ from o-(trimethylsilyl)aryl triflates and KF, reacted smoothly with 2-(2-benzyl-2H-tetrazol-5-yl)-2H-azirines give 3-(2-benzyl-2H-tetrazol-5-yl)-indole high selectivity. Deprotection of the gave 3-(1H-tetrazol-5-yl)-indole derivatives.
Abstract A series of title compounds is prepared and the cytotoxic properties some them are evaluated against 8 tumoural cell lines.