Background . Many studies have shown that neutrophil extracellular traps (NETs) in the form of web-like structures are present peripheral blood patients with inflammatory diseases. In our research, addition to traditional NET structures, several anomalous forms were identified, including NETs cloud-like appearance. Aim To investigate morphological and functional transformation under influence Klebsiella pneumoniae immunoglobulin G (IgG). Materials methods The study included 42 Moscow City...

SARS-CoV-2 is a novel coronavirus that has been identified as the cause of 2019 infection (COVID-19), which originated at Wuhan city PRC in late and widespread worldwide. As number patients recovering from COVID-19 continue to grow, it’s very important understand what health issues they may keep experiencing. now recognized an infectious disease can multiple organ diseases various localization. It against this background new term was introduced: post-acute post-COVID-19 syndrome...

Post-COVID syndrome is characterized by fatigue, reduced exercise tolerance, muscle and joint pain, psychoemotional disorders. In the development of a generalized body response in viral infection, abnormal defense responses are great importance. We studied neutrophils, neutrophil extracellular traps (NETs), DNA degradation products (purine nitrogenous bases, PNBs), traditional biochemical parameters. Aim . To determine parameters number NETs PNBs peripheral blood patients with post-COVID...

Background. Neutrophil extracellular traps (NETs) are net-like structures that have been investigated in inflammatory diseases. However, the presence of NETs infected persons without clinical symptoms has not yet studied. Aim. To reveal healthy during and after H1N1 influenza pandemic as well to study functional activity NETs. Materials methods. The included two groups volunteers ( n = 10 each group) aged 20–25 years. first group was examined absence acute diseases one month before chronic...

Развитие инфекционных осложнений у больных с воспалительными заболеваниями определяется тем, насколько эффективную защитную реакцию нейтрофилы больного будут развивать при контакте патогеном. Противоинфекционная устойчивость организма во многом готовностью нейтрофилов формировать нейтрофильные сети, способные эффективно захватывать патогены. Цель исследования. Определение параметров нейтрофильных экстраклеточных ловушек (НЭЛ) брюшной полости. Методика. Обследованы 28 прооперированных...

Abstract Substituted N ‐(silatran‐1‐ylmethyl)acetamides, ‐methyl‐ ‐[1‐(3′,7′,10′‐trimethylsilatran‐1‐yl)methyl]acetamide (2a) and ‐(2‐hydroxyethyl)‐ (2b) were prepared by the reactions of triisopropanolamine with ‐(trimethoxysilylmethyl)acetamide (1a) 2,2‐dimethoxy‐4‐acetyl‐1‐oxa‐4‐aza‐2‐silacyclohexane (1b), respectively. According to X‐ray data, structures silatrane moieties are superpositions unsymmetrical symmetrical stereoisomers. The O → Si coordination between central atom exocyclic...

We investigated the immunocorrective and clinical effect in 75 rheumatoid patients treated with intravenous laser blood irradiation. A relation between positive immunotropic (as well as therapeutic) pre-existent immune status of each patient was revealed. well-defined found a low level CIC normal count functional-competent T-cells. ILIB provided some symptomatic but unstable relief high functional activity T-lymphocytes. There no decreased number lymphocytes.

Нейтрофильные экстраклеточные ловушки -регуляторы формирования врожденного и адаптивного иммунитета А

Currently in clinical practice widely used drugs local antimicrobial such as Tantum Verde (benzydamine) Rosa Miramistin (benzyldimethyl-miristoilamino-propylammonium) Hexoral (hexetidin), chlorhexidine (chlorhexidine), Septolete total (benzydamine + cetylpyridinium chloride). The mechanism of action these very similar. We evaluated the effect on viability lymphoid tissue cells and their neutrophilic part immune system, which are most important factors immunity and, at same time, system is...

The article analyzes the functional state (evacuation functions, continence) and innervation of pelvic floor muscles in patients with rectocele combination internal rectal intussusception, complaints obstructive defecation. AIM. study defecation syndrome (ODS). MATERIALS AND METHODS. included 224 women defecation, without surgery. On physical examination, all were detected signs rectocele. average age - 49,9±15,0 years. 52 (23,2%) had to fecal incontinence various components. Diagnostic...

<h3></h3> Обсуждаются перспективы фармакологического кондиционирования как способа адаптации нейроваскулярной единицы к условиям нейротропной вирусной инфекции. Представлены поэтапные механизмы прекондиционирования и посткондиционирования с подробной характеристикой основных этапов (триггерного, сигнального эффекторного). Рассмотрена роль нейровоспаления ведущего механизма повреждения, а также возможности воздействия на мозговой нейротрофический фактор. Индукторами могут выступать различные...

The aim of this investigation is the comparative study changes in surface phenotype lymphocyte patients with different forms atopic diseases and latent sensitization. Materials methods. was conducted on peripheral blood lymphocytes from 22 sensitization patients, 30 pollinosis 44 bronchial asthma 36 dermatitis patients. control group consisted 26 healthy people. results our studies demonstrate that are not only clinical manifestations, but also mechanisms disturbances functions immune...

Aim. To assess clinical and prognostic significance of dyspnea when leaning forward in elderly outpatients. Material methods. The open, prospective, non-randomized study included 55 outpatients &gt;60 years old with class II-IV (NYHA) chronic heart failure (CHF) as a result coronary artery disease or hypertension body mass index (BMI) &lt;30 kg/m 2 . Routine physical examination, laboratory tests echocardiography were conducted. Results. Dyspnea was detected 45% patients. Bendopnea...

The pathogenetic mechanisms of progression chronic periodontitis accompanied with rheumatoid arthritis is confirmed by the common parts immune-inflammatory reactions. Damage to periodontal tissues indirectly made cytotoxic effects enzymes and their metabolites produced Porphyromonas gingivalis bacteria. Neutrophils contribute participate in its amplification recruiting T-helper cells 17 contributing accumulation plasma affected tissues. Activation immunocompetent promotes generation reactive...

Introduction . Interferon-containing drugs are frequently used, but their effect on the innate immune cells response and adaptive immunity parameters is not well known. Aim To investigate of interferon-alpha-containing production neutrophil extracellular traps, population subpopulation composition peripheral blood lymphocytes in cell culture conditions. Materials methods We used from 12 healthy donors 6 patients with acute inflammation, which was as a lymphocyte source. Neutrophil traps were...

One of the important problems medicine is search for new reliable markers inflammation that would allow us to determine type inflammatory process. The aim study was identify specific infectious and aseptic based on analysis morphological variants neutrophil extracellular traps (NETs). included 26 patients with various nosological forms in abdominal cavity (12 acute appendicitis, 8 cholecystitis, 6 a diagnosis pancreatitis/ pancreonecrosis) after surgery. also 20 post-COVID group 10...

Aim. To study the effect of a new complex compound LHT-2-20 (2-ethyl-6-methyl-3-hydroxypyridine-2-(3benzoyl phenyl)-propanoate) on free radical oxidation in experimental periodontitis. Materials and methods. The was performed 195 white mongrel mice weighing 19–23 g 137 rats 180–220 g. (2-ethyl-6methyl-3-hydroxypyridine-2-(3-benzoyl intensity local state periodontal tissues during course intragastric administration studied model Statistical processing results carried out using SPSS Statistics...