A5092087583- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Adolescent and Pediatric Healthcare
- Characterization and Applications of Magnetic Nanoparticles
- Nursing Diagnosis and Documentation
- Sperm and Testicular Function
- Emergency and Acute Care Studies
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Sepsis Diagnosis and Treatment
University of Sri Jayewardenepura
2021-2024
University of Oxford
2021-2024
Nuffield Health
2023-2024
Nuffield Orthopaedic Centre
2023
Background Preeclampsia (PE) is a pregnancy-specific hypertensive disorder affecting 2%–8% of pregnancies worldwide. Biomarker(s) for the exists, but while these have excellent negative predictive value, their positive value poor. Extracellular vesicles released by placenta into maternal circulation, syncytiotrophoblast membrane extracellular (STB-EVs), been identified as being involved in PE with potential to act liquid biopsies. Objective The objective this study was identify difference...
Abstract Background Preeclampsia (PE) is a pregnancy-specific hypertensive disorder affecting 2-8% of pregnancies worldwide. Biomarker(s) for PE exists, but while these have excellent negative predictive value, their positive value poor. Extracellular vesicles released by the placenta into maternal circulation, syncytiotrophoblast membrane extracellular - STB-EVs-have been identified as being involved in with potential to act liquid biopsies. Objective To identify differences STB-EV and...
Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is leading cause adverse maternal and fetal outcomes. Current clinical PE tests have low positive predictive value for prediction diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into circulation.To identify difference in STB-EV proteome between normal (NP), which could lead to identifying potential biomarkers mechanistic...
Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is leading cause adverse maternal and fetal outcomes. Current clinical PE tests have low positive predictive value for prediction diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into circulation.To identify difference in STB-EV proteome between normal (NP), which could lead to identifying potential biomarkers mechanistic...
Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is leading cause adverse maternal and fetal outcomes. Current clinical PE tests have low positive predictive value for prediction diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into circulation.To identify difference in STB-EV proteome between normal (NP), which could lead to identifying potential biomarkers mechanistic...
Abstract Background Placentae of women with preeclampsia (PE) exhibit reduced levels kynurenine (Kyn), a biological compound derived from tryptophan metabolism antioxidant, vasorelaxant, and hypotensive properties. Little is known regarding functional the Kyn metabolizing enzymes (KYNME) in preeclampsia. Since high circulating syncytiotrophoblast extracellular vesicles (STB-EVs) have been associated onset, we aimed to study whether reduction may be attributed increased degradation by KYNME...
Abstract Background Cerebrovascular complications are the leading cause of maternal mortality associated with preeclampsia. Extracellular vesicles (EVs) containing microRNAs (miRNAs) and derived from syncytiotrophoblast (STB-EVs) suspected to play a role in these complications. Previously, we found that STB-EVs placentas women preeclampsia have higher content angiogenesis regulator hsa-miR-9-5p. We now investigate effects hsa-miR-9-5p on proangiogenic properties brain endothelial cells...
Abstract Background Preeclampsia (PE), a multi-systemic hypertensive pregnancy disease that affects 2-8% of pregnancies worldwide, is leading cause adverse maternal and fetal outcomes. Current clinical PE tests have low positive predictive value for prediction diagnosis. The placenta notably releases extracellular vesicles from the syncytiotrophoblast (STB-EV) into circulation. Objective To identify difference in STB-EV proteome between normal (NP), which could lead to identifying potential...
Preeclampsia (PE) is a hypertensive disorder in pregnancy affecting 2-8% of pregnancies worldwide and remains one the leading causes maternal neonatal morbidity mortality. PE characterized by hypertension end-organ damage secondary to oxidative stress, endothelial dysfunction, vasoconstriction. The pathophysiology disease being elusive, early screening, diagnosis, effective management challenging. Traditionally several predictive models including clinical biochemical parameters have been...