A5044145220- Global Health Care Issues
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Healthcare Systems and Practices
- Global Health Workforce Issues
- Intergenerational Family Dynamics and Caregiving
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Health, Medicine and Society
- Retirement, Disability, and Employment
- Migration, Aging, and Tourism Studies
- Aging, Elder Care, and Social Issues
- Health disparities and outcomes
- Crystallization and Solubility Studies
- Obesity, Physical Activity, Diet
- X-ray Diffraction in Crystallography
- Healthcare innovation and challenges
- Lung Cancer Treatments and Mutations
- Healthcare Systems and Reforms
- Global Cancer Incidence and Screening
- Chronic Disease Management Strategies
- Birth, Development, and Health
Institute of Biomedical Technologies
2020-2025
National Research Council
2020-2025
University of Milan
2011-2025
European Institute of Oncology
2021-2025
National Academies of Sciences, Engineering, and Medicine
2020-2024
Greater Manchester STEM Centre
2024
Organisation de Coopération et de Développement Economiques
2003-2024
National Center for Oncological Hadrontherapy
2024
IRCCS Humanitas Research Hospital
2023
University of Siena
2021-2023
Spending on health in OECD countries continues to rise and now accounts for around 9% of GDP, average. The high cost systems the strain public purse mean that financial sustainability is policy-makers’ agenda. Paramount among key factors pushing up expenditure over recent years have been advances medical technology, population ageing increasing expectations vis-à-vis their systems.Drawing data 30 member countries, authors examine main trends spending decades present variations across...
Abstract SARS-CoV-2 has caused a worldwide epidemic of enormous proportions, which resulted in different mortality rates countries for unknown reasons. We analyzed factors associated with using data from the Italian national database more than 4 million SARS-CoV-2-positive cases diagnosed between January 2020 and July 2021, including > 415 thousand hospitalized coronavirus disease-19 (COVID-19) 127 deceased. For patients whom age, sex date infection detection were available, we determined...
The findings of mutations and the development targeted therapies have improved lung cancer management. Still, prognosis remains poor, we need to know more about genetic epigenetic alterations in cancer. MicroRNAs are involved crucial biological processes like carcinogenesis by regulating gene expression at post-transcriptional level. In this project, studied microRNA adenocarcinomas corresponding normal tissue correlated with clinical data EGFR- KRAS-mutational status. Agilent microarrays...
Abstract Associations between clinical outcome of cancer patients and the gene expression signature in primary tumors at time diagnosis have been reported. To test whether patterns noninvolved lung tissue might correlate with stage adenocarcinoma (ADCA) patients, we compared transcriptome samples from 60 ADCA smoker I versus >I. Quantitative PCR 10 genes most significant differential confirmed statistical association eight genes, six which were downregulated high‐stage patients. Five...
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, from whole-exome sequencing data about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting severity. First, converted into separate sets Boolean features, depending on the absence or presence each gene. An ensemble LASSO logistic regression models was identify most informative features with respect genetic...
The Lancet COVID-19 Commission calls for three urgent actions in the response (our broader overview is available on our website). First, all regions with high rates of new cases, including USA and European Union (EU), should intensify measures to minimise community transmission alongside rapid deployment vaccines. Second, governments urgently fully fund WHO Access Tools (ACT) Accelerator,1 COVAX. Third, G20 countries empower International Monetary Fund (IMF) multilateral development banks...
Abstract Background This study analyzes the effect of frailty and Post-Operative Delirium (POD) on functional status at hospital discharge 4-month follow-up in patients with hip fracture (HF). Methods Multicenter prospective observational older HF admitted to 12 Italian Orthogeriatric centers (July 2019-August 2022). POD was assessed using 4AT. A 26-item Frailty Index (FI) created data collected admission. The outcome measures were Cumulated Ambulation Score (CAS) ≤ 2 a...
Isopentenyladenosine (i(6)A) is a product of isopentenyltransferases and, in mammals, occurs either bound to tRNA or as free nucleoside. Sporadic reports have suggested an anticancer effect i(6)A, mostly on leukemia cells. The present analysis 9 human epithelial cancer cell lines derived from different types malignant tissue revealed complete suppression clonogenic activity 8 the after exposure i(6)A at concentration 10 muM. Mechanistic studies showed that tumor suppressor associated with...
Abstract Background MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block genetic elements associated with progression of lung cancer. Results Here we show that expression is strongly downregulated in non-small cell cancer lines different histotypes and primary adenocarcinomas. Experimental modulation cells alteration mRNA levels genes involved cycle control interaction the extracellular matrix. Exogenous induced G1...
Chromosomal locus 15q25, implicated in lung cancer risk and nicotine dependence, shows extensive linkage disequilibrium that complicates identification of causal variation. Cholinergic receptor nicotinic alpha5 (CHRNA5) has been identified as a factor. We by sequence analysis three haplotypes (delTTC, insATC, insTGG) the 5' promoter region at 3'-untranslated CHRNA5. Linkage variants showed insTGG haplotype is associated with tightly linked alleles (nicotine cancer, chronic obstructive...
Asbestos exposure is the main etiology of malignant mesothelioma, but there are conflicting data on whether intensity modulates development this disease. This study considered 594 patients with mesothelioma for whom count asbestos bodies and fibers (per gram wet lung tissue) were available. The relationships between age at diagnosis (a time-to-event outcome variable) these two measures internal exposure, along other possible modulating factors (sex, tumor location, histological subtype...