A5084933686- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Statistical Methods in Clinical Trials
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Hepatitis Viruses Studies and Epidemiology
- Statistical Methods and Bayesian Inference
- Hepatitis B Virus Studies
- Advanced Causal Inference Techniques
- Folate and B Vitamins Research
Medical University of South Carolina
2021-2025
Autoimmune hepatitis is a common cause of acute liver failure. Treatment includes steroids for injury and transplantation in those who fail to respond or develop The aim this study further characterize failure secondary autoimmune identify variables that predict 21-day transplant-free survival. This included adults hospitalized with enrolled the Acute Liver Failure Study Group Registry between 1998 2019 from 32 centers within US. etiology all cases was reviewed by Adjudication Committee,...
The Fibrosis-4 index (FIB-4) can reliably assess fibrosis risk in patients with chronic liver disease, and advanced is associated severe disease (SLD) outcomes. However, CLD underdiagnosed primary care. We examined the association between FIB-4 strata incidence of SLD preceding a diagnosis while considering incident diagnoses as competing risks.
ABSTRACT This manuscript derives the allocation predictability measured by correct guess probability and of being deterministic for individual treatment assignments, as well averages a randomization sequence, based on imbalance transition matrix conditional probability. The methods described are applicable to restricted designs that satisfy following criteria: (1) two‐arm equal allocation, (2) restriction maximum tolerated imbalance, (3) fully determined observed current imbalance....
The fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS) are noninvasive accessible methods for assessing advanced liver risk in primary care. We evaluated the distribution of FIB-4 NFS scores care patients with clinical signals nonalcoholic fatty disease (NAFLD).This retrospective cohort study electronic record data between 2007 2018 included adults at least one abnormal aminotransferase no known (non-NAFLD) disease. calculated patient-level scores, proportion mean values exceeding...
Alanine aminotransferase (ALT) has long provided a cue for chronic liver disease (CLD) diagnostic evaluation, but the Fibrosis-4 Index (FIB-4), serologic score used predicting advanced fibrosis risk in CLD, may provide an alternative signal. Compare predictive performance of FIB-4 with ALT severe (SLD) events while adjusting potential confounders. Retrospective cohort study primary care electronic health record data from 2012 to 2021. Adult patients at least two sets and other lab values...
Goals and Background: Using natural language processing to create a nonalcoholic fatty liver disease (NAFLD) cohort in primary care, we assessed advanced fibrosis risk with the Fibrosis-4 Index (FIB-4) NAFLD Fibrosis Score (NFS) evaluated score agreement. Materials Methods: In this retrospective study of adults radiographic evidence hepatic steatosis, calculated patient-level FIB-4 NFS scores categorized them by risk. Risk category agreement was analyzed using weighted κ, Pearson...
Abstract Background The etiology of acute liver failure (ALF) remains one the most important factors in determining prognosis and predicting outcomes. In a significant proportion ALF cases, however, unknown is categorized as indeterminate (IND‐ALF). this study, we summarize findings from patients with IND‐ALF 32 transplant centers across United States, compare laboratory, prognostic, outcome data for IND‐ALF. Methods Between 1998 2019, 3364 adult or injury (ALI) were enrolled ALFSG registry....
We propose the use of a mean quadratic variation criteria to determine an optimal trading strategy in presence price impact. derive Hamilton Jacobi Bellman (HJB) Partial Differential Equation (PDE) for strategy, assuming underlying asset follows Geometric Brownian Motion (GBM) or Arithmetic (ABM). The exact solution ABM formulation is fact identical static (price-independent) approximate mean–variance objective function Almgren and Chriss (2000). GBM case general price. determined turns out...
The Fibrosis-4 Index (FIB-4) has demonstrated a strong association with severe liver disease (SLD) outcomes in primary care, but previous studies have only evaluated this relationship using 1 or 2 FIB-4 scores. In study, we determined the of as time-varying covariate SLD risk time-dependent Cox regression models.
Background: The Fibrosis-4 Index (FIB-4) non-invasively assesses fibrosis risk in chronic liver disease, but underdiagnosis limits FIB-4’s application primary care. This study evaluates the association of FIB-4 with severe outcomes care patients and without diagnosed disease.Methods: retrospective cohort data from 2007 to 2018 Included adult qualifying aminotransferase platelet count results. A single score was calculated for each patient using first these values. Patients a disease...