A5101893521- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Nausea and vomiting management
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Pain Management and Opioid Use
- Healthcare and Venom Research
- Dermatology and Skin Diseases
- Veterinary Pharmacology and Anesthesia
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Osteoarthritis Treatment and Mechanisms
- Sinusitis and nasal conditions
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
- Botulinum Toxin and Related Neurological Disorders
- NF-κB Signaling Pathways
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
University of Science and Technology of China
2021-2024
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Anhui Provincial Hospital
2014-2022
Shandong University
2017-2022
Ningxia Hui Autonomous Region Peoples Hospital
2018
Anhui Medical University
2014-2017
Goethe University Frankfurt
2006-2011
A large body of evidence indicates that the release nitric oxide (NO) is crucial for central sensitization pain pathways during both inflammatory and neuropathic pain. Here, we investigated distribution NO-sensitive guanylyl cyclase (NO-GC) in spinal cord dorsal root ganglia, characterized nociceptive behavior mice deficient NO-GC (GC-KO mice). We show distinctly expressed neurons mouse horn, whereas its ganglia restricted to non-neuronal cells. GC-KO exhibited a considerably reduced models...
Despite the availability of various antiepileptic treatments, approximately 30 % epilepsy patients remain refractory to conventional therapies, underscoring need for neuroprotective strategies. This study investigates role GrpEL1 in modulating mitochondrial unfolded protein response (UPRmt) and its potential protective effects on hippocampal neurons following experimental status epilepticus (SE). The were assessed vivo using a Lithium-pilocarpine rat model SE vitro with glutamate-treated...
The synaptic vesicle protein synapsin II is specifically expressed in terminals of primary afferent nociceptive neurons and regulates transmitter release the spinal cord dorsal horn. Here, we assessed its role nerve injury-evoked molecular behavioral adaptations models peripheral neuropathic pain using mice genetically lacking II. Deficiency resulted reduced mechanical cold allodynia two pain. This was associated with decreased glutamate horn upon sciatic injury or capsaicin application onto...
The goal of this study was to evaluate the analgesic efficiency dexamethasone with ropivacaine in continuous serratus anterior plane block (cSAPB) after video-assisted thoracoscopic surgery (VATS).Sixty-six patients who underwent VATS were randomized into two groups. All received cSAPB postoperatively, and Group RD 20 mL 0.375% plus 0.1 mg/kg followed by an infusion 0.2% 0.02 mg/kg/hour at a rate 5 mL/h patient-controlled analgesia (PCA) pump. Patients R normal saline PCA Fifty milligrams...
Alcohol use disorder is highly prevalent worldwide, with characteristically severe pain sensitivity during withdrawal. Here, we established a mouse model of hyperalgesia ethanol withdrawal (EW) before addiction to investigate the window for onset and underlying mechanisms. Viral tracing in vivo microendoscopic two-photon calcium imaging identified circuit pathway from dorsal hippocampal CA1 glutamatergic neurons (dCA1 Glu ) anterior cingulate cortex (ACC activated EW mice hyperalgesia....
Inflammatory pain is known to severely impact the life quality of patients. Notably, dezocine widely used for treatment pain. Therefore, current study aimed examine effects on a complete Freund's adjuvant (CFA)-induced inflammatory model in rats and investigate possible underlying molecular mechanisms. Rats were randomly divided into three groups, including control, CFA dezocine+CFA then subcutaneously injected with 100 µl saline, or pretreated 1 ml (0.4 µg/kg) at 30 min before injection...
Background. Hong-Hui-Xiang (HHX) is a sterilized aqueous solution extracted from Illicium lanceolatum A.C. Smith widely used for pain relief in China. Despite its history, it not well understood. In the present study, we mouse model of arthritic knee to investigate antinociceptive effects HHX and potential side on weight respiratory function, as liver, kidney, heart. Methods. Mice were randomly assigned four groups: saline at three doses (1 μl, 10 50 μl). Each group was divided two...
Abstract Background and Objectives Nonsteroidal anti‐inflammatory drugs (NSAIDs) have an response, but it remains unclear whether the perioperative use of flurbiprofen axetil can influence postoperative tumor recurrence survival in esophageal carcinoma. We aimed to explore effect intravenous on recurrence‐free (RFS) overall (OS) patients with carcinoma who underwent thoracoscopic esophagectomy. Methods This retrospective study included surgery for between December 2009 May 2015 at Department...
Abstract Background: Treatment of chronic pain is challenged by concurrent anxiety symptoms. Dexmedetomidine known to produce sedation, analgesia, and anxiolysis. However, the neural mechanism dexmedetomidine-elicited anxiolysis remains elusive. Here, we aimed test hypothesis that anterior cingulate cortex might be involved in dexmedetomidine-induced pain. Methods: A common peroneal nerve ligation mouse model was used analgesia assessing mechanical allodynia, open-field, light-dark...
Objective To determine the optimum dose of nalbuphine prepared for patient-controlled intravenous analgesia(PCIA)after caesarean section. Methods A total 100 parturients, aged 22-40 yr, weighing 60-90 kg, American Society Anesthesiologists physical statusⅠor Ⅱ, at≥37 weeks gestation, scheduled elective section, were divided into 4 groups(n=25 each)using a random number table: sufentanil 2.0 μg/kg group(group S), 1.5 mg/kg N1), N2)and 2.5 N3). In S, N1, N2 and N3 groups, 1.5, added to...