A5020595029- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Hearing, Cochlea, Tinnitus, Genetics
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Pain Management and Placebo Effect
- Music Therapy and Health
- Memory and Neural Mechanisms
- IL-33, ST2, and ILC Pathways
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Vestibular and auditory disorders
- Vibrio bacteria research studies
- Ion Transport and Channel Regulation
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
Shanghai Jiao Tong University
2022-2025
Songjiang District Central Hospital
2022-2025
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
University of Science and Technology of China
2014-2023
Chinese Academy of Sciences
2015-2023
Hefei National Center for Physical Sciences at Nanoscale
2019-2022
Xinxiang Medical University
2021
Capital Normal University
2021
South China Sea Institute Of Oceanology
2021
Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise mice. Viral tracing, microendoscopic calcium imaging, multitetrode recordings freely moving mice showed low-SNR sounds inhibited glutamatergic inputs from auditory cortex (ACxGlu) thalamic posterior (PO) ventral (VP) nuclei. Optogenetic or chemogenetic...
Neurotransmitters have been shown to regulate immune responses, and thereby are critically related autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation hepatic iNKT cells augmented concanavalin A (Con A)-induced liver injury. The suppressive effect dopamine on was mediated by D1-like receptor-PKA pathway. Clearance gut microbiota antibiotic cocktail reduced synthesis in intestines exacerbated damage, could be restored recovery or...
While comorbid pain in depression (CP) occurs at a high rate worldwide, the neural connections underlying core symptoms of CP have yet to be elucidated. Here, we define pathway whereby GABAergic neurons from central nucleus amygdala (GABACeA) project glutamatergic parafascicular (GluPF). These GluPF relay directly second somatosensory cortex (S2), well-known area involved signal processing. Enhanced inhibition GABACeA→GluPF→S2 is found mice exhibiting symptoms. Reversing this using...
Abstract Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural circuit mechanisms underlying comorbid in (CASP) context of chronic remain unclear. Using viral neuronal tracing mice, we identified a previously unknown pathway whereby glutamatergic neurons from layer 5 hindlimb primary somatosensory cortex (S1) (Glu S1 ), well-known brain region involved processing, project to GABAergic caudal dorsolateral striatum (GABA cDLS ). In persistent inflammatory...
Light has been shown to relieve pain, but the underlying neural mechanisms remain unknown. Here, we show that low-intensity (200 lux) green light treatment exerts antinociceptive effects through a circuit from visual cortex projecting anterior cingulate (ACC) in mice. Specifically, viral tracing, vivo two-photon calcium imaging, and fiber photometry recordings activated glutamatergic projections medial part of secondary (V2MGlu) GABAergic neurons ACC, which drives inhibition local...
Abstract Background Long‐term non‐traumatic noise exposure, such as heavy traffic noise, can elicit emotional disorders in humans. However, the underlying neural substrate is still poorly understood. Methods We exposed mice to moderate white for 28 days induce anxiety‐like behaviors, measured by open‐field, elevated plus maze, and light–dark box tests. In vivo multi‐electrode recordings awake were used examine neuronal activity. Chemogenetics silence specific brain regions. Viral tracing,...
The enhanced AMPA receptor phosphorylation at GluA1 serine 831 sites in the central pain-modulating system plays a pivotal role descending pain facilitation after inflammation, but underlying mechanisms remain unclear. We show here that, rat brain stem, nucleus raphe magnus, which is critical relay of brain, persistent inflammatory induced by complete Freund adjuvant (CFA) can enhance receptor-mediated excitatory postsynaptic currents and GluA2-lacking rectification index. Western blot...
Pain is a multidimensional perception that includes unpleasant somatosensory and affective experiences; however, the underlying neural circuits mediate different components of pain remain elusive. Although hyperactivity basolateral amygdala glutamatergic (BLAGlu) neurons required for emotional processing pain, precise excitatory inputs to BLAGlu their roles in mediating aspects are unclear. Here, we identified two discrete neuronal male mice: projection from insular cortex (ICGlu) neurons,...
Anxiety is often comorbid with pain. Delta opioid receptors (DORs) are promising targets for the treatment of pain and mental disorders little addictive potential. However, their roles in anxiety symptoms at different stages unclear. In current study, mice inflammatory fourth hour following complete Freund's adjuvant (CFA) injection displayed significant anxiety-like behavior, which disappeared seventh day. Combining electrophysiology, optogenetics, pharmacology, we found that activation...
Pain symptoms can be transmitted across generations, but the mechanisms underlying these outcomes remain poorly understood. Here, we identified an essential role for primary somatosensory cortical (S1) glutamate neuronal DNA methyl-CpG binding protein 2 (MeCP2) in transgenerational transmission of pain. In a female mouse chronic pain model, offspring displayed significant sensitization. mice, MeCP2 expression was increased S1 (GluS1) neurons, correlating with activity. Downregulation GluS1...
Our previous study demonstrated that persistent pain can epigenetically suppress the transcription of <i>Gad2</i> [encoding glutamic acid decarboxylase 65 (GAD65)] and consequently impair inhibitory function GABAergic synapses in central pain-modulating neurons. This contributes to development sensitization. Histone deacetylase (HDAC) inhibitors increased GAD65 activity considerably, restored GABA synaptic function, rendered sensitized behavior less pronounced. However, molecular mechanisms...
Depression is the leading cause of disability worldwide, and its treatment represents a major clinical challenge.
The purpose of this study was to explore whether prenatal gut microbiota (GM) and its functions predict the development offspring temperament. A total 53 mothers with a 1-year-old child 41 2-year-old were included in using mother-infant cohort from central China. Maternal fecal samples collected during third trimester analyzed 16S rRNA V3-V4 gene sequences. Temperament measured by self-reported data according primary caregiver. effects GM on offspring's temperament evaluated multiple linear...
摘要:
Bacteriophages (phages) and their bacterial hosts were the most abundant genetically highly diverse organisms on earth. In this study, a series of phage-resistant mutant (PRM) strains derived from Vibrio alginolyticus isolated Infrequent-restriction-site PCR (IRS-PCR) was used to investigate genetic diversity PRM strains. Phenotypic variations eight analyzed using profiles utilizing carbon sources chemical sensitivity. Genetic coevolved V. populations with phages by whole-genome sequencing...