A5100677106- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic Cross-Coupling Reactions
- Advanced NMR Techniques and Applications
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Pain Mechanisms and Treatments
- RNA Research and Splicing
- Solid-state spectroscopy and crystallography
- Monoclonal and Polyclonal Antibodies Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Fiber-reinforced polymer composites
- Heat shock proteins research
- Sirtuins and Resveratrol in Medicine
- Click Chemistry and Applications
- thermodynamics and calorimetric analyses
- Catalytic Alkyne Reactions
- Physiological and biochemical adaptations
- Botulinum Toxin and Related Neurological Disorders
- RNA and protein synthesis mechanisms
- Nanofabrication and Lithography Techniques
- Synthesis and properties of polymers
- Nuclear Receptors and Signaling
Research Center for Eco-Environmental Sciences
2025
Chinese Academy of Sciences
2022-2025
University of Science and Technology of China
2009-2025
First Affiliated Hospital of Bengbu Medical College
2025
Hefei National Center for Physical Sciences at Nanoscale
2019-2024
Soochow University
2017-2022
Guiyang Medical University
2022
Guizhou Center for Disease Control and Prevention
2022
State Council of the People's Republic of China
2017
Tsinghua University
2007-2011
Many amyloid fibrils associated with neurodegenerative diseases consist of an ordered fibril core (FC) and disordered terminal regions (TRs). The former represents a stable scaffold, while the latter is rather active in binding various partners. Current structural studies mainly focus on FC since high flexibility TRs hinders characterization. Here, by combining insensitive nuclei enhanced polarization transfer-based 1H-detected solid-state NMR cryo-EM, we explored intact structure α-syn...
N,N-Dimethyl-β-alanine was found to be a more powerful phosphine-free ligand than the previously reported ligand, N,N-dimethylglycine, in Pd-catalyzed Heck reaction for variety of aryl bromides, iodides, and activated chlorides with practical turnover number 103. Both kinetic theoretical studies suggested that N,N-dimethyl-β-alanine led faster oxidative addition an halide Pd N,N-dimethylglycine.
The amyloid fibrils of α-synuclein (α-syn) are crucial in the pathology Parkinson's disease (PD), with intrinsically disordered region (IDR) its C-terminal playing a key role interacting receptors like LAG3 and RAGE, facilitating pathological neuronal spread inflammation. In this study, we identified Givinostat (GS) as an effective inhibitor that disrupts interaction α-syn such RAGE through high-throughput screening. By exploring structure-activity relationship optimizing GS, developed...
The DNA-sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid–liquid phase separation (LLPS) enhances enzymatic activity cGAS. However, regulatory mechanisms disordered N terminus remain unclear. Here, we showed that Nterm , N-terminal intrinsic region (IDR) cGAS, modulates material properties, specifically flowability, condensed is required for full activity. Full-length form liquid droplets presence DNA, while...
Abstract Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural circuit mechanisms underlying comorbid in (CASP) context of chronic remain unclear. Using viral neuronal tracing mice, we identified a previously unknown pathway whereby glutamatergic neurons from layer 5 hindlimb primary somatosensory cortex (S1) (Glu S1 ), well-known brain region involved processing, project to GABAergic caudal dorsolateral striatum (GABA cDLS ). In persistent inflammatory...
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules, promote pathological protein aggregation in neurodegenerative diseases. Here, we demonstrate that G3BP2, a core component of stress directly interacts Tau and inhibits aggregation. In the human brain, interaction G3BP2 is dramatically increased multiple tauopathies, it independent neurofibrillary tangle (NFT) formation Alzheimer's disease (AD). Surprisingly, pathology significantly elevated upon loss neurons...
Abstract Vacuum ultraviolet (VUV) lasers have demonstrated great potential as the light source for various spectroscopies, which, if they can be focused into a small beam spot, will not only allow investigation of mesoscopic materials and structures but also find application in manufacture nano-objects with excellent precision. In this work, we report construction 177 nm VUV laser that achieve record-small (~0.76 μm) focal spot at long length (~45 mm) by using flat lens without spherical...
Objective Traumatic rupture of the lens zonules, leading to dislocation, is common in clinical practice and often requires surgical treatment. We aim study capsular hooks, formed from 5-0 or 6-0 polypropylene sutures by heat shaping, fix bag reshape zonular. Methods A retrospective analysis was conducted on 16 patients (16 eyes) with traumatic subluxation crystalline who visited our department. Capsular hooks were fabricated using sutures, shape heat, anterior opening. The passed out eye,...
The persistent leaching of per- and polyfluoroalkyl substances (PFAS) from landfills poses significant environmental risks, particularly to surrounding water systems. However, information regarding the occurrence fate PFAS in across country is limited. Here we investigated distribution profiles sources 60 landfill leachate 31 provinces mainland China, showing total levels ∑PFAS 3.05 × 103 1.58 105 ng/L. Structural equation modeling revealed that socioeconomic conditions directly influenced...
PA6/grafted-SGO (g-SGO) nanocomposite fibers show improved mechanical-properties due to excellent dispersibility of g-SGO and strong interaction between PA6.
Solid-state nuclear magnetic resonance (ssNMR) methods can probe the motions of membrane proteins in liposomes at atomic level and propel understanding biomolecular processes for which static structures cannot provide a satisfactory description. In this work, we report our study on fluoride channel Fluc-Ec1 phospholipid bilayers based ssNMR molecular dynamics simulations. Previously unidentified binding sites aqueous vestibules were experimentally verified by 19F-detected ssNMR. One two...
Abstract A new pyridoxal‐5‐phosphate (PLP) derivative FHMDP was developed for the transamination of different peptides with three most hindered amino acid residues (Leu, Ile, Val) as their N‐terminus. Compared to previously reported reactions PLP derivatives, N‐terminus could be accomplished efficiently compound.
Essence of software testing is to choose a representative value (known as test case) from the input perform programs under test. The actual results will be checked verify consistency with expected ones. If are different, it should take some correction and adjustment correspondingly. existing method for suite generation mainly based on requirements which related given objectives. It generates suites directly. Inevitably, data in those may redundant need reduced. In fact, case selection make...
Functionalized partially unzipped carbon nanotubes (f-PUCNTs) as reinforcements obviously improve mechanical and thermal properties of polyimide (PI)-based composite fibers.