A5000240047- Child Nutrition and Water Access
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Iron Metabolism and Disorders
- Epigenetics and DNA Methylation
- Food Security and Health in Diverse Populations
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Genetic Associations and Epidemiology
- Plant Micronutrient Interactions and Effects
- Gestational Diabetes Research and Management
- Diverse Scientific Research Studies
- Global Health and Epidemiology
- Historical and modern epidemiology studies
- Gut microbiota and health
- Global Public Health Policies and Epidemiology
- Food Waste Reduction and Sustainability
- Food composition and properties
- Phytase and its Applications
- Mangiferin and Mango Extracts
- Bariatric Surgery and Outcomes
- IL-33, ST2, and ILC Pathways
- Porphyrin Metabolism and Disorders
- Genetic Syndromes and Imprinting
Dr. BMN College of Home Science
2024
Social Change and Development
2012-2023
Shreemati Nathibai Damodar Thackersey Women's University
2020-2022
University of Southampton
2014
Medical Research Council
2014
National Institute for Health Research
2014
Low birth weight (LBW) is an important public health problem in undernourished populations.We tested whether improving women's dietary micronutrient quality before conception and throughout pregnancy increases a high-risk Indian population.The study was nonblinded, individually randomized controlled trial. The intervention daily snack made from green leafy vegetables, fruit, milk (treatment group) or low-micronutrient vegetables (potato onion) (control ≥ 90 d until delivery addition to the...
Background: Prospective observational studies suggest that maternal diets rich in leafy green vegetables and fruit may help prevent gestational diabetes mellitus (GDM). Objective: Our objective was to test whether increasing women's dietary intake of vegetables, fruit, milk before conception throughout pregnancy reduced their risk GDM. Methods: Project SARAS ("excellent") (2006–2012) a nonblinded, individually randomized, controlled trial women living slums the city Mumbai, India. The...
Young children living in urban slums are vulnerable to malnutrition and subsequently poor health outcomes, but data on the correlates of stunting, underweight, wasting, anemia specifically among 10-18 month-old India remain limited.
Vitamin B12 is an important cofactor in one-carbon metabolism whose dysregulation associated with various clinical conditions. Indians have a high prevalence of deficiency but little known about the genetic determinants circulating concentrations Indians. We performed genome-wide association study 1001 healthy participants Pune Maternal Nutrition Study (PMNS), replication studies 3418 individuals from other Indian cohorts and by meta-analysis identified new variants, rs3760775 (P = 1.2 ×...
In this cross-sectional study, we describe the composition and diversity of gut microbiota among undernourished children living in urban slums Mumbai, India, determine how nutritional status, including anthropometric measurements, dietary intakes from complementary foods, feeding practices, micronutrient concentrations, is associated with their microbiota. We collected rectal swabs aged 10 to 18 months Mumbai participating a randomized controlled trial conducted 16S rRNA sequencing Across...
Animal studies have shown that nutritional exposures during pregnancy can modify epigenetic marks regulating fetal development and susceptibility to later disease, providing a plausible mechanism explain the developmental origins of health disease. Human observational maternal peri-conceptional diet predicts DNA methylation in offspring. However, causal pathway from diet, through changes methylation, outcomes has yet be established. The EMPHASIS study (Epigenetic Mechanisms linking...
To (1) describe micronutrient intakes among women of reproductive age living in Mumbai slums; (2) assess the adequacy these compared with reference values; (3) identify important dietary sources micronutrients. Participants were 6426 non-pregnant aged 16–39 years, registered a randomised controlled trial food-based intervention set Bandra, Khar and Andheri areas Mumbai, India. Cross-sectional quantified food frequency questionnaire (FFQ) data collected. Vitamin (n = 9) mineral 6) calculated...
Abstract Improving micronutrient intakes of under‐nourished mothers in low‐ and middle‐income countries increases birth weight, but there is little data on the nature timing during gestation any effects fetal growth. Ultrasound measures size were used to determine whether when a food‐based supplement affected Non‐pregnant women living Mumbai slums, India ( N = 6,513), randomly assigned receive either daily micronutrient‐rich snack containing green leafy vegetables, fruit, milk (treatment) or...
Intakes of micronutrient-rich foods are low among Indian women reproductive age. We investigated whether consumption a food-based snack increased markers blood micronutrient concentrations when compared with control snack. Non-pregnant ( n 222) aged 14–35 years living in Mumbai slum were randomised to receive treatment (containing green leafy vegetables, dried fruit and whole milk powder), or containing content such as wheat flour, potato tapioca. The snacks consumed under observation 6 d...
Maternal nutrition influences fetal development and may permanently alter ("program") offspring body composition metabolism, thereby influencing later risk of diabetes cardiovascular (cardiometabolic) disease. The prevalence cardiometabolic disease is rising rapidly in India.To test the hypothesis that supplementing low-income Indian women with micronutrient-rich foods preconceptionally during pregnancy has a beneficial impact on children's marker profiles.Follow-up 1255 children aged 5-10 y...
Background & aimsBiofortification of staple crops with higher levels micronutrients via traditional breeding methods is a sustainable strategy and can possibly complement fortification other interventions to target micronutrient deficiencies in low resource settings, particularly among vulnerable populations such as children. We aimed determine if iron- zinc-biofortified pearl millet (FeZnPM, Dhanashakti, ICTP-8203Fe)-based complementary feeding improves nutritional status, including iron...
Abstract Background The prevalence of cardiometabolic disease (CMD) is rising globally, with environmentally induced epigenetic changes suggested to play a role. Few studies have investigated associations CMD risk factors in children from low- and middle-income countries. We sought identify between DNA methylation (DNAm) India Gambia. Results Using the Illumina Infinium HumanMethylation 850 K Beadchip array, we interrogated DNAm 293 Gambian (7–9 years) 698 Indian (5–7 children. identified...
To explore influences on the diet and physical activity of adolescents living in Mumbai slums, from perspectives their caregivers.Three investigators conducted six focus group discussions.The study was suburban slums.Thirty-six (aged 10-12 15-17 years) twenty-three caregivers were recruited through convenience sampling.The findings highlighted complex negotiations between adolescent surrounding junk food consumption opportunities. Caregivers learned recipes to prepare popular foods encourage...
Background: Mango, known as "the king of fruits," is one the most popular fruits on planet. Vitamins, minerals, antioxidants, and bioactive substances abound. Objective: In present review, we aimed to explore therapeutic effects mango an antioxidant. Methods: Scopus ScienceDirect databases were used gather research papers over pre-vious 12 years. Results: Our explores formidable antioxidant potential mango, driven by its ele-vated phenolic flavonoid content. Within crucial metabolites such...
Abstract Objective: To explore perceptions of how context shapes adolescent diet and physical activity in eight low- middle-income (LMIC) sites at different stages societal economic transition. Design: Novel qualitative secondary analysis data sets generated as part the international Transforming Adolescent Lives through Nutrition (TALENT) collaboration. Setting: Diverse India Sub-Saharan Africa. Participants: Fifty-two focus group discussions with 491 participants (303 adolescents aged...
Abstract Objective: To describe the anthropometry, socioeconomic circumstances, diet and screen time usage of adolescents in India Africa as context to a qualitative study barriers healthy eating activity. Design: Cross-sectional survey, including measured height weight derived rates stunting, low BMI, overweight obesity. Parental schooling employment status, household assets amenities, adolescents’ dietary diversity, intake snack foods, mobile/smartphone ownership TV/computer were obtained...
There are few data on the fatty acid status of non-pregnant Indian women. Our objective was to investigate effect a snack containing green leafy vegetables (GLVs) women's erythrocyte long chain polyunsaturated (LCPUFA).
Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation child four LMIC cohorts (n = 1927) identify a robust association at three CpGs suppressor cytokine signaling 3 (SOCS3) gene which replicates high-income country cohort 879). SOCS3 (SOCS3m)-height associations are independent genetic effects. Mendelian randomization...