A5072063017- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Tuberculosis Research and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Medicinal Plants
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Advanced Drug Delivery Systems
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Bee Products Chemical Analysis
- Regulation of Appetite and Obesity
- Drug Transport and Resistance Mechanisms
- Iron Metabolism and Disorders
- Pneumonia and Respiratory Infections
- Cystic Fibrosis Research Advances
- Paraoxonase enzyme and polymorphisms
- GDF15 and Related Biomarkers
- Liver Diseases and Immunity
- Computational Drug Discovery Methods
- Genetic factors in colorectal cancer
- Folate and B Vitamins Research
- Esophageal and GI Pathology
- Apelin-related biomedical research
- Child Nutrition and Water Access
Topiwala National Medical College & BYL Nair Charitable Hospital
2015-2025
National Institute of Immunohaematology
2022
Chronic consumption of fructose causes obesity and nonalcoholic fatty liver disease (NAFLD). Currently available therapies have limitations; hence there is a need to screen new molecules. Plumbagin naphthoquinone present in the roots Plumbago species which has hypolipidemic hepatoprotective activities.Rats were divided into five groups: normal control, orlistat, plumbagin (0.5 mg/kg 1 body weight). The control group received standard diet drinking water while remaining groups alongwith for...
Lichen planus (LP), a T-cell-mediated inflammatory disorder, wherein inflammation produces lipid metabolism disturbances, is linked to increase in cardiovascular (CV) risk with dyslipidemia. Increased reactive oxygen species and peroxides have also been implicated its pathogenesis.The aim of the study was evaluate status on oxidative stress, LP patients.The initiated after obtaining Institutional Ethics Committee permission written informed consent from participants. The included 125...
Basti (medicated enema) is a popular Ayurvedic intervention recommended for obesity. However, there are no data to show whether any physiological or biochemical changes occur following this treatment. This study was conducted identify the immunological and metabolic in obese individuals after therapeutic course of Basti.Thirty two (18 60 yr) with body mass index (BMI) ≥30 kg/m [2] who received 16 enemas (Basti) followed by specific diet lifestyle regimen period 32 days as their treatment...
Intakes of micronutrient-rich foods are low among Indian women reproductive age. We investigated whether consumption a food-based snack increased markers blood micronutrient concentrations when compared with control snack. Non-pregnant ( n 222) aged 14–35 years living in Mumbai slum were randomised to receive treatment (containing green leafy vegetables, dried fruit and whole milk powder), or containing content such as wheat flour, potato tapioca. The snacks consumed under observation 6 d...
<br><b>OBJECTIVE:</b> To determine prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations in apparently healthy individuals residing Mumbai and patients with deep vein thrombosis (DVT) coronary artery disease (CAD) to correlate these polymorphisms homocysteine (Hcy) levels.<br><b>MATERIALS AND METHODS:</b> This case–control study was initiated after receiving ethical approval following the participant's written consent. One hundred twenty unmatched volunteers 240 arterial venous...
Background: Paraoxonase is a calcium dependent enzyme which bound to high density lipoprotein and acts primarily by inhibiting low oxidation. Its activity modulated PON1 polymorphism. Objective: In the present case control study we determined genotype frequencies of Q192R L55M in Indian population association between PON lipid markers patients with coronary artery disease (CAD). Methods: 635 angiographically proven CAD from Cardiology & Medicine OPDs our hospital age- matched controls were...
Objectives: To assess the change in bone mineral density (BMD) score, bone-specific biomarkers (serum vitamin D3, tartrate-resistant acid phosphatase 5b [TRAP-5b], and osteocalcin), quality of life, Ayurvedic symptoms (Asthikshaya Lakshanas), fracture risk assessment tool (FRAX) scores following treatment with Panchatikta Ghrita (PG), a classical herbal formulation as add-on therapy to calcium D3 supplements. Study design: Randomized, open-labeled, comparative, controlled clinical study....
Osteoporosis is a public health problem in the elderly wherein decrease bone mass and mineral density increases at risk of fractures. Panchatikta Ghrita (PG) classical Ayurvedic formulation that may help slow degeneration. This experimental study was conducted to assess efficacy ghrita protecting against postmenopausal osteoporosis ovariectomized rats. The experiment initiated after Institutional Animal Ethics Committee approval. 96 female Sprague Dawley rats were divided into 8 groups viz....
The N-acetyltransferase 2 (NAT2) gene exhibits substantial genetic diversity, leading to distinct acetylator phenotypes among individuals. In this study, we determine NAT2 polymorphisms in tuberculosis (TB) patients and analyze serum isoniazid (INH) concentrations across the various genotypes. An observational prospective cohort study involving 217 with pulmonary or extrapulmonary TB was carried out. genotypes were identified using real-time polymerase chain reaction technology. INH at...