- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Plant-Derived Bioactive Compounds
- Multicomponent Synthesis of Heterocycles
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Chronic Myeloid Leukemia Treatments
- Synthesis and Biological Evaluation
- Botanical Research and Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Inorganic and Organometallic Chemistry
- Organometallic Compounds Synthesis and Characterization
- Natural product bioactivities and synthesis
- Lung Cancer Treatments and Mutations
- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Phenothiazines and Benzothiazines Synthesis and Activities
- Quinazolinone synthesis and applications
- Chemical Thermodynamics and Molecular Structure
- Tannin, Tannase and Anticancer Activities
- Pharmacogenetics and Drug Metabolism
Tamil Nadu Dr. M.G.R. Medical University
2022
SRM Institute of Science and Technology
2022
University of Tabuk
2018
Swami Vivekanand College of Pharmacy
2011-2016
Telangana University
2015
Delhi Pharmaceutical Science and Research University
2008-2009
Malaysian Rubber Board
1972-1978
Abstract The Waters Model 200 Gel Permeation Chromatograph has been used to study the molecular weight distribution of natural rubber. cumulative curve synthetic cis-polyisoprene from GPC method showed fair agreement with obtained by fractional precipitation. For rubber was not so good. Natural samples six clones Hevea Brasiliensis were examined GPC. Differences observed in their distributions. Five a distinct bimodal distribution. and number average weights found be too low. Some possible...
A simple, precise and accurate method was developed validated for analysis of Ketorolac Tromethamine in eye drop formulation. An isocratic HPLC performed on Kromosil C18 column (150 cm × 4.6 mm 5 μm). The compound separated with the mixture methanol ammonium dihydrogen phosphate buffer ratio 55:45 V/V, pH 3.0 adjusted O-phosphoric acid as mobile phase at flow 1.5 mL min−1. UV detection 314 nm using photo diode array detection. retention time found to be 6.01 min. system suitability...
In this study, a simple, precise and accurate reverse phase high performance liquid chromatography was developed for the estimation of Erlotinib in bulk pharmaceutical dosage forms. A Merck C18 column (250 cm × 4.6 mm 5 μm) with mobile consisting potassium dihydrogen orthophosphate acetonitrile (70:30 V/V) having pH 5.0 adjusted orthophosphoric acid used. The flow rate 0.8 mL min−1 effluents were monitored at 246 nm. retention time found to be 4.54 min. linearity drug obtained range 10–60 μg...
A novel, precise, rapid and sensitive reverse phase high performance liquid chromatographic method has been developed for the validated estimation of Tadalafil in bulk tablet dosage form. The separation was achieved on Agilent Eclipse XDB C<sub>18</sub> column (150 mm×4.6 mm, 5 µ) using a mobile that consists buffer (potassium dihydrogen orthophosphate) acetonitrile ration 50:50 V/V, pH 6 adjusted with orthophosphoric acid. flow rate maintained at 1.2 ml/min detection wavelength 285 nm....
Background: Dihydropyrimidinone is considered as a pharmacophoric skeleton in many drug discovery programmes. To explore the activity of dihydropyrimidines, we regioselectively synthesized some substituted mannich bases dihydropyrimidinone (DHPM) analogues with fluoroquinolones (Ciprofloxacin). Methods: Regioselectivity these structures achieved by influence weak base like potassium carbonate and novel dihydropyrimidine N- O-Mannich ciprofloxacin (3a-j, 4a-g) using microwave technology. All...
The 3,4-disubstituted-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione derivatives were synthesized and characterized by physicochemical spectral means, the results of antimicrobial study these compounds against Staphylococcus aureus, Escherichia coli, Candida albicans tube dilution method indicated that 4-(4-chlorophenyl)-3-(4-nitrophenylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 6 4-(4-fluorophenyl)-3-(4-nitrophenylsulfonyl)-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thione 12 most...
A simple, robust, precise and accurate reverse phase liquid chromatographic method was developed for simultaneous estimation of Atazanavir sulphate Ritonavir in combined tablet dosage form by RP-HPLC method. Chromatography carried out on a Nucleodur C18Â column (150 mm x 4.6 5 m) using Acetonitrile: Methanol: Phosphate buffer, pH adjusted to 3.0 with orthophosphoric acid the ratio 44:11:45 (V/V) as mobile at flow rate 1.5 mL min-1Â eluents were monitored 210 nm. The calibration curves linear...
Abstract Ova (n=62), which were collected from slaughterhouse bovine ovaries, and embryos (n=26), non-surgically recovered 11 superovulated crossbred donor cows, frozen. The frozen ova then thawed using two conventional thawing protocols, i.e. at 37 °C for 30 seconds in a water bath 25 2 minutes air. Some 64.5% of the 53.8% 16.1% 7.7% ambient air exhibited fractured z:onae pellucidae. slow protocol had lower incidence zona damage cryopreserved oval than fast protocol. A low pregnancy rate...
A precise, simple, and validated Reverse-phase high-performance liquid chromatography (RP-HPLC) method alongside spectrophotometric analysis has been established for the simultaneous quantification of clobetasol propionate, miconazole nitrate, salicylic acid in an updated ointment formulation. The impact organic modifiers on retention target compounds was assessed. chromatographic conducted using a simple low-pressure gradient with UV detection at 282 nm C18 column (5 ?m, 4.6 ? 250 mm HSS)....
In the present study we are reporting dissolution, method development and validation of water soluble vitamins B1, B2 & B6 in bulk tablet dosage form by HPTLC method. The is based on separation three using HPTLC. Thin layer chromatographic plates coated with silica gel 60F254 as stationary phase acetonitrile:water (6:4 v/v) mobile phase. analysis was carried out reflectance absorbance mode at 280 nm. validated respect to linearity, accuracy precision, limit detection quantitation. It...
Recent study was conducted to develop and validate analytical methods for estimation of Risedronate sodium in pure pharmaceutical dosage form using UV Spectroscopy and  RP- HPLC method. The first method (Method A) based on the using 0.1M Hcl as diluent lambda max found at 261 nm. Linearity existed perceived concentration between 10-50 μg/ml (r 2 = 0.999) method. validated pertaining linearity, precision accuracy studies, LOD LOQ consistent with ICH guidelines. second B),...
A RPHPLC chromatographic method was developed and validated for the determination of Quinapril Hydrochlorothiazide in bulk powder pharmaceutical formulations. can be separated on Zorbax Eclipse XDB, C18 column (150 x 4.6 mm, 5 mm) at 30 C using Acetonitrile: Phosphate buffer, pH 4.5 adjusted with o-phosphoric acid ratio 35:65 v/v as a mobile phase flow rate 0.9 mL min-1Â detected 210 nm. The retention time Hydrochlorthiazide found to 2.099 min 5.537 respectively. validation proposed carried...
AimThe extensive literature survey revealed that number of methods was reported but there is no method for the simultaneous estimation Atorvastatin Calcium, Aspirin, Ramipril and Metoprolol tartrate in combination by UV-spectroscopy. MethodThe use first order derivative spectrophotometry allowed fixed dose products.The absorbance values at 291.5 nm, 247 242.5 nm 229.5 spectrum used Tartrate, respectively without mutual interference. Results ConclusionThis obeyed Beer's law concentration 3...
Cancer is the most dreadful of all diseases and major contributors to mortality in world. Out population, almost 1.2 million patients die due cancer related problems. The rate spread are wide even both women men. It presently as high 3.5 people who have India alone. There many ways treatment like surgery, radiation therapy, cryosurgery chemotherapy. A part chemotherapy usage a lot chemicals synthetic drugs. Due side effects chemotherapy, often get symptoms drugs, so toxic. Because this,...
INTRODUCTION:3-(9H-carbazol-4-yloxy)-2-hydroxypropyl [2-(2methoxyphenoxy) ethyl] amine (Figure1) Carvedilol is used to treat heart failure and hypertension (high blood pressure).It also after a attack that has caused your not pump as well.Mechanism of action racemic mixture in which nonselective beta-adrenoreceptor blocking activity present the S (-) enantiomer alpha-adrenergic both R (+) enantiomers at equal potency.Carvedilol's beta-adrenergic receptor ability decreases rate, myocardial...