A5018891045- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Synthesis and Biological Evaluation
- Phosphodiesterase function and regulation
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactions of Organic Compounds
- Essential Oils and Antimicrobial Activity
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- PARP inhibition in cancer therapy
- Receptor Mechanisms and Signaling
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Ginger and Zingiberaceae research
- Quinazolinone synthesis and applications
Delhi Pharmaceutical Science and Research University
2015-2024
University of Delhi
2016-2020
AIMST University
2020
Astellas Pharma (India)
2020
South Eastern Railway
2018
Owing to its presence in several biological processes, Sirt1 acts as a potential therapeutic target for many diseases. Here, we report the structure-based designing and synthesis of two distinct series novel inhibitors, benzimidazole mono-peptides amino-acid derived 5-pyrazolyl methylidene rhodanine carboxylic acid. The compounds were evaluated
Sirt1–3 are the most studied sirtuins, playing a key role in caloric-dependent epigenetic modifications. Since they localized distinct cellular compartments and act differently under various pathological conditions, selective inhibition would be promising strategy to understand their biological function discover effective therapeutics. Here, sirtuin's inhibitor Ex527* is used as probe speculate possible root cause of differential structural dynamics Sirt1–3. Comparative energetics mutational...
Objective: To develop and validate simple, sensitive, precise, rapid cost effective method for determination of Canagliflozin in bulk pharmaceu tical formulations as per ICH Guidelines. Methods: A simple double beam UV Spectrophotometric has been developed validated with different parameters such Linearity, Precision, Repeatability, Limit Detection (LOD), Quantification (LOQ), Accuracy, Robustness Rug gedness. Results: methanol shows maximum absorbance at 290 nm. Beer’s law was obeyed the...
Hydrodistilled oil obtained from the stem bark of Myrica esculenta Buch. Ham. ex D. Don (yield 0.3%) was analysed by capillary GC and GC-MS. The volatile consisted mainly n-hexadecanol (25.2%), eudesmol acetate (21.9%), palmitic acid (11.6%), cis-β-caryophyllene (8.7%), n-pentadecanol (7.7%) n-octadecanol (7.6%). found to be a potential antimicrobial agent against Bacillus pumilus, Staphylococcus aureus, epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus...
Swertia alata C.B Clarke (Gentianaceae) is a well-reported plant in the traditional system of medicine. The present study was intended to isolate phytoconstituents from ethanolic extract aerial parts S. alata; and evaluate for vitro COX-1/COX-2 inhibition activity, vivo anti-inflammatory ulcerogenic activity. Phytoisolation involved partitioning into petroleum ether chloroform soluble fractions using silica gel-based column chromatography. isolation afforded two phytoisolates, namely...
Greater cardamom (Amomum subulatum Roxb. Zingiberaceae) commonly known as "Bari ilaichi" is a well plant used in Ayurvedic and Unani medicine. It has been for the treatment of various diseases disorders like gastric ulcer. Therefore antimicrobial activity petroleum ether, methanol aqueous extracts from leaves roots, essential oil isolated vasicine A. vasica were tested against microorganisms. Antimicrobial was done by disc diffusion method. The zone inhibition observed compared with that...
Abstract Hydrodistilled oil obtained from the whole plant of Valeriana jatamansi Jones. was analyzed by capillary GC and GC-MS. The volatile consisted mainly sesquiterpenes viz. carotol (10 %), germacrene B (9.5 cis-β-farnesene (8 α-humulene (6.8 %) humulene oxide (6.4 %). found to be a potential antimicrobial agent against Bacillus pumilus, Staphylococcus aureus, epidermidis, Escherichia coli, Pseudomonas aeruginosa Candida albicans. When studied for topical anti-inflammatory activity in...
A series of new pyrimidine–triazine hybrids ( 4a–t ) was designed and synthesized, from which potent anticonvulsant agents were identified. Most the compounds exhibited promising activity against maximal electroshock (MES) subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment higher safety compared to standard drugs, phenytoin carbamazepine. In series, 5‐(4‐(4‐fluorophenyl)‐6‐(4‐hydroxyphenyl)‐2‐thioxo‐5,6‐dihydropyrimidin‐1(2 H...
Three receptor tyrosine kinases (RTKs), c-MET, EGFR, and VEGFR-2 have been identified as potential oncogenic targets involved in tumor development, metastasis, invasion. Designing inhibitors that can simultaneously interact with multiple is a promising approach, therefore, inhibiting these three RTKs single chemical component might give an effective chemotherapeutic strategy for addressing the disease while limiting adverse effects. The in-silico methods developed to identify...
Cost-effectiveness analysis of Dapagliflozin versus Canagliflozin in treatment type 2 diabetes mellitusSadagoban Gopal Krishnamoorthy, Jemi Rachel Shaji, Bhagya Premnath, Akshitha Rani Siby, Swathi Swaroopa Borra , Ayilya Manomohan, Arun Kanniyappan Parthasarathy