A5101433956- Synthesis and biological activity
- Conducting polymers and applications
- Synthesis and Biological Evaluation
- Inflammatory mediators and NSAID effects
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Organic Electronics and Photovoltaics
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Synthesis of heterocyclic compounds
- Analytical chemistry methods development
- Essential Oils and Antimicrobial Activity
- Computational Drug Discovery Methods
- DNA and Biological Computing
- Genome Rearrangement Algorithms
- Synthesis of Tetrazole Derivatives
- Adenosine and Purinergic Signaling
- Diverse Scientific Research Studies
- Natural Antidiabetic Agents Studies
- Scientific and Engineering Research Topics
- Covalent Organic Framework Applications
- Nanocomposite Films for Food Packaging
- Garlic and Onion Studies
- Characterization and Applications of Magnetic Nanoparticles
Shree Guru Gobind Singh Tricentenary University
2020-2024
Maharishi Markandeshwar University, Mullana
2024
Chandigarh University
2023
Gurugram University
2022
Delhi Pharmaceutical Science and Research University
2014-2020
University of Waterloo
2020
Ghent University
2020
Brigham and Women's Hospital
2020
Harvard University
2020
University of Delhi
2010-2020
Protein-based films and coatings are highly biodegradable represent sustainable alternatives to petroleum-based materials. These materials possess commendable barrier properties, effectively safeguarding against oxygen, moisture, aroma compounds, rendering them well-suited for various food packaging applications. Beyond their role in packaging, have significant applications the biomedical pharmaceutical domains. Their inherent biocompatibility controlled release properties make valuable such...
Abstract: Cancer is the second leading cause of death worldwide. As per reports published by WHO, cases cancer in world will increase to 22 million 2030. Many resources are investigated all around for developing preventive, diagnostic and therapeutic strategies cancer. Malignant cells display metabolic changes because genetic epigenetic alterations as compared normal cell. Heterocycles key structural feature many anti-cancer drugs present market. Between 2010 2015, FDA approved anticancer...
A series of N-(2-(4-chlorobenzyl)benzo[d]oxazol-5-yl)-3-substituted-propanamide (3a-3n) were synthesized and evaluated for their acute chronic anti-inflammatory potential. The structure the compounds was elucidated by elemental spectral (IR, 1H NMR MS) analysis. (at a dose 20 mg/kg b.wt. p.o.) have shown ability to provide 45.1-81.7% protection against carrageenan-induced paw edema, in comparison with diclofenac sodium (69.5%) ibuprofen (64.7%). most active 3a, 3l 3n screened activity...
Swertia alata C.B Clarke (Gentianaceae) is a well-reported plant in the traditional system of medicine. The present study was intended to isolate phytoconstituents from ethanolic extract aerial parts S. alata; and evaluate for vitro COX-1/COX-2 inhibition activity, vivo anti-inflammatory ulcerogenic activity. Phytoisolation involved partitioning into petroleum ether chloroform soluble fractions using silica gel-based column chromatography. isolation afforded two phytoisolates, namely...
The twelve most effective dibenzo-α-pyrone derivatives as anticonvulsant chemicals have been chosen from our earlier study, and their 2D structures determined. Using Spartan'14 version 1.1.2, the compounds' 3D were generated, optimized, transferred in PDB format. Molecular docking investigations of drugs utilized Toshiba Satellite, Dual-core CPU, Windows 8 operating system, AutoDockVina PyRx virtual screening program. was activated with flexible option to dock GABAAT enzyme, NMDA, (Ligands)...
Abstract: The signal transduction and cell proliferation are regulated by the epidermal growth factor receptor. of tumor cells, apoptosis, invasion, angiogenesis is inhibited Thus, breast cancer, non-small lung cervical glioma, bladder cancer can be treated targeting Although third-generation receptor inhibitors potent drugs, patients exhibit drug resistance after treatment. search for new drugs being continued. Among different inhibitors, we have reviewed indole-based inhibitors. We...
Non-steroidal anti-inflammatory drugs are widely used for many years, but the chronic use of NSAID's leads to gastric side effects, ulceration and kidney problems. These effects due non-selective inhibition COX-2 along with COX-1. Therefore, it is imperative develop novel selective inhibitors.In this paper wehave synthesized a series hybrids comprising substituted-N- (3,4,5-trimethoxyphenyl)-benzo[d]oxazole derivatives screened treatment inflammation.The structures obtained compounds were...
Abstract A series of N ‐(2‐(3,5‐dimethoxyphenyl)benzoxazole‐5‐yl)benzamide derivatives ( 3am ) was synthesized and evaluated for their in vitro inhibitory activity against COX‐1 COX‐2. The compounds with considerable (IC 50 < 1 μM) were vivo anti‐inflammatory potential by the carrageenan‐induced rat paw edema method. Out 13 newly compounds, 3a , 3b 3d 3g 3j 3k found to be most potent COX‐2 inhibitors enzymatic assay, IC values range 0.06–0.71 μM. these six assessed Compounds (84.09%),...
The present study was intended to evaluate the in vitro (COX-1/COX-2) and vivo anti-inflammatory ulcerogenic activity of newer phytoconstituents isolated from aerial parts Swertia alata C.B. Clarke (Gentianaceae). For isolation phytoconstituents, ethanolic extract S. subjected column chromatography using mixture petroleum ether chloroform various concentrations, which yielded two phytoisolates characterised as nonacosyl triacontanoate (SA-3)...
Core–shell polymer functionalized magnetic nanoparticles are promising material for rapid immunomagnetic separation and detection of analyte.
Ultrasound assisted facile synthesis of fluorenyl-hydrazonothiazoles (4a-d) in quantitative yields by the condensation 2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide (2) with substituted phenacyl bromides presence dimethyl formamide has been reported. The reaction carbothioamide 2 α-haloacids resulted to fluorenyl-hydrazonothiazolidin-4-ones (3). structural characterization cyclized products have established elemental analysis and spectral data (IR, NMR mass). antimicrobial studies...