The use of novel antimicrobial molecules in bone cement can improve efficiency recuperation after arthroplasty or joint replacement surgeries, avoiding the risks associated with antibiotic resistant agents. Nanomaterials particularly dendrimers are useful for making broad spectrum killing agents owing to their large surface areas and functionalities. Therefore, we have synthesized generation 1 quaternary ammonium dendrimer tripropylene glycol diacrylate (TPGDA) using octyl iodide (OI) [TPGDA...

Metal- and additive-free, photoinduced decarboxylative radical alkylation–cyclization of CF3-acrylamides with alkyl redox-active esters provided the corresponding quaternary CF3-oxindole derivatives in good yields. Notably, diaryliodonium salts also efficiently participated arylation–cyclization environmentally benign H2O as a solvent. The present approach has been extended for concise synthesis CF3-attached indoline alkaloid analogues, i.e., CF3-(±)-desoxyeseroline, CF3-(±)-esermethole,...

We have demonstrated a Pd(0)-catalyzed Heck/C(sp3)–H activation cascade for the synthesis of spirocyclopropyl oxindoles in high yields from easily accessible ortho-bromoacrylamides. The formation oxindole is guided by an unconventional four-membered palladacycle through C(sp3)–H activation. reaction exhibits wide range substrate scope and operates efficiently with mere 0.5 mol % Pd-catalyst. In addition, use microwave conditions facilitates rapid completion reaction. Furthermore, this...

Abstract Surface of nylon membrane was modified by the graft copolymerization glycidyl methacrylate (GMA) using persulfate and thiosulfate as redox initiator system. Effect various reaction parameters such concentration, monomer polymerization time, temperature on degree grafting also studied. Maximum 100% achieved equimolar concentration (0.008 M ) 0.5 GMA at 70°C in 60 min. Grafted membranes with levels were characterized techniques fourier transform infrared spectroscopy, thermo...

Novel, size controlled fluorescent polymeric nanoparticles (FPNP) were synthesized having acetoacetoxy functionality on the surface for immobilization of biomolecules which can be utilized as biomarkers and labels in fluoroimmunoassays. Core–shell poly(styrene, St–methyl methacrylate, MMA–acetoacetoxy ethyl AAEM), stabilized by various concentrations surfactant, sodium lauryl sulphate (SLS), obtained facile miniemulsion co-polymerization encapsulated with pyrene molecules their hydrophobic...

Calcium alginate microbeads (212–425 μm) were prepared by spraying 2% (w/v) solution into 1 M CaCl2 solution. The fluidization behavior of these beads was studied, and the bed expansion index terminal velocity found to be 4.3 1808 cm h−1, respectively. Residence time distribution curves showed that dispersion protein much less with than conventionally calcium macrobeads when both kinds used for chromatography in a fluidized format. purification pectinase from commercial preparation. media...

Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering vast water industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC...

Core–shell polymer functionalized magnetic nanoparticles are promising material for rapid immunomagnetic separation and detection of analyte.

Herein, we have demonstrated an operationally simple Pd-catalyzed double-Heck reaction between N-(o-bromoaryl)acrylamide derivatives and α-fluoro/trifluoromethyl acrylates to enable monofluoro/trifluoromethyl alkene tethered 3,3-disubstituted oxindoles in a stereoselective manner. Remarkably, the proceeds well without any external ligand open-air atmosphere. Control experiments spectroscopic analysis are performed understand mechanism.

We have developed an efficient Cu/N,N-bidentate imine ligand catalytic system for C(sp3)–C(sp) coupling to obtain internal alkynes, di/trisubstituted allenes and strained bridged cyclic lactams in moderate excellent yields from readily available alkyl(benzyl) bromides one-pot transformation. Density Functional Theory (DFT) assisted mechanistic study along with control experiments support the involvement of bialkynylated copper species which undergo single electron transfer (SET) alkyl...

A sensitive and rapid method for the detection of pathogenic bacteria (Salmonella typhi) in water sample was developed using core-shell CdSe / ZnS quantum dots (QDs) as fluorescence label. Surface-functionalized were synthesized by successive ion layer adsorption reaction (SILAR) technique made hydrophilic ligand exchange method. Developed hydrophobic QDs characterized transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), spectrofluorimetry. Carboxy-...

ABSTRACT Polyacrylonitrile (PAN)‐based antimicrobial polymeric microspheres were synthesized and characterized in the present study. In first approach, hydrolysis of PAN microsphere was performed alkaline medium to generate carboxylic groups, followed by iodination obtain iodine incorporated hydrolyzed microspheres. second pendant nitrile groups reduced lithium aluminum hydride amino functionality. Incorporation agent achieved reacting glycidyltrimethylammonium chloride onto amine‐terminated...