Fused thienopyridines represent a class of heterocyclic molecules that have garnered increasing attention due to their unique structural features and versatile chemical properties. This review systematically examines the latest synthetic methodologies employed in preparing fused thienopyridine derivatives, emphasizing innovative approaches contribute diversity. Moreover, discussion extends broad spectrum therapeutic applications offer, encompassing utility different diseases. The explores...

The review summarises various photo- and electrochemical strategies for trifluoromethylation fluoroalkylation of different C(sp 3 )–H, 2 C(sp)–H bonds in several classes organic molecules.

An efficient, one-pot, and green synthesis of 3-amino/hydroxy thieno[3,2- c ]pyrans was acheived from 2-oxo-2 H -pyran-3-carbonitriles/carboxylates in water.

Metal- and additive-free, photoinduced decarboxylative radical alkylation–cyclization of CF3-acrylamides with alkyl redox-active esters provided the corresponding quaternary CF3-oxindole derivatives in good yields. Notably, diaryliodonium salts also efficiently participated arylation–cyclization environmentally benign H2O as a solvent. The present approach has been extended for concise synthesis CF3-attached indoline alkaloid analogues, i.e., CF3-(±)-desoxyeseroline, CF3-(±)-esermethole,...

A facile synthesis of highly functionalized spirobutenolides was carried out by a nitroalkane carbanion-induced ring opening and relactonization via denitration reaction 2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles 2-oxo-2,5-dihydrothiochromeno[4,3-b]pyran-3-carbonitriles. However, when nitroethane used as nucleophile source in lieu nitromethane, mixture (E)- (Z)-isomers the corresponding obtained different ratio. The structure geometry product were confirmed single-crystal X-ray...

We have developed a simple, efficient and chemoselective approach for the synthesis of m-teraryls by reaction 6-aryl-2-oxo-4-(sec.amino)-2H-pyran-3-carbonitriles 2-(1-arylethylidene)malononitriles under basic conditions. used 6-aryl-2-oxo-4-methylsulfanyl-2H-pyran-3-carbonitriles as precursors successfully afforded 5'-methylsulfanyl-[1,1';3',1'']teraryl-4'-carbonitriles. tried to understand difference in reactivity structurally symmetrical molecules, such allyl cyanide,...

An efficient iodine-mediated method is developed for the synthesis of functionalized 2-(methylthio)-4H-chromen-4-ones by intramolecular cyclization easily accessible 1-(2-benzyloxy-aryl)-3,3-bis-methylsulfanyl-propenones. The synthesized chromen-4-ones turn out to be a key precursor various kinds chemical reactions. Mechanistically, we observed that ketene dithioacetal proceeded through radical pathway. 3-Halo-2-(methylthio)-4H-chromen-4-ones were achieved via two- or one-pot halogenation approaches.

The rapid advancement of nanotechnology has boosted the applications TiO2 nanoparticles (TiO2 NPs) in various industries, resulting their release into marine environments. This review article provides a comprehensive overview recent findings on adverse effects NPs algae and zooplankton. Special attention is given to underlying mechanisms toxicity, including oxidative stress, genotoxicity, disruptions cellular processes. consolidates scientific evidence underscore emerging concerns...

A base controlled regioselective 1,6-cyanoallylation of suitably functionalized 2<italic>H</italic>-pyran-2-ones has been demonstrated for the synthesis various multi-substituted benzenes through a tandem process.

Abstract A base‐mediated carbocyclization study has been performed between two allowed Baldwin cyclization modes (6‐ exo‐ trig and 6‐ dig) it was found that preferred over dig. Allyl cyanide to be suitable efficient pronucleophile for this investigation sp 2 –sp transition‐metal‐free C−C bond formations took place in a single operation yield differently functionalized biaryl compounds.

Both one pot and step wise synthesis of methyl 3,5-diaminothieno[3,2-<italic>c</italic>]pyridin-4-one-2-carboxylates<bold>6</bold>have been delineated by the reaction 6-aryl-4-methylthio-2<italic>H</italic>-pyran-2-one-3-carbonitriles<bold>3</bold>, mercaptoacetate hydrazine hydrate.

Heterocycles are very important scaffolds since many of them exhibit building blocks properties and good biological activities. Various chemical methods have been utilized for their synthesis out them, the environmentally benign approaches highly demanding in view importance green chemistry. There vast pieces literature available on sustainable multi-component synthetic approaches, but it is difficult a researcher to keep up with research. Therefore, review article heterocycle was required....

Microwave mediated regiodivergent synthesis of highly functionalized 1,2-teraryls has been reported.

Abstract A green and base‐free desulfitative coupling of different thioethers with aryl boronic acids in water. Various thiomethylated 2 H ‐pyran‐2‐ones, 2‐oxobenzo[ h [chromones α ‐aroyl ketene‐dithioacetals were used as substrate to obtained arylated product very good excellent yield. Further utility reaction was carried out by a one‐pot arylation followed amination α‐aroyl ketene dithioacetals for the synthesis 3‐amino chalcones diarylazoles. The structure isolated 4 6 c ascertained...

Metal-free substituent dependent synthesis of fluorescent fluorenones was reported.

A [5 + 1] annulation approach was used to access multifunctional biaryls and <italic>p</italic>-teraryls from ketene dithioacetals.