A5103120151- Metal complexes synthesis and properties
- Inorganic and Organometallic Chemistry
- COVID-19 Clinical Research Studies
- Synthesis and biological activity
- Reproductive System and Pregnancy
- Long-Term Effects of COVID-19
- Magnetism in coordination complexes
- SARS-CoV-2 and COVID-19 Research
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- SARS-CoV-2 detection and testing
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Endometriosis Research and Treatment
- Complementary and Alternative Medicine Studies
- Phytochemicals and Medicinal Plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Vagus Nerve Stimulation Research
- Respiratory Support and Mechanisms
- Reproductive Biology and Fertility
- Multicomponent Synthesis of Heterocycles
- Preterm Birth and Chorioamnionitis
- Digital Imaging for Blood Diseases
- Estrogen and related hormone effects
- Organic Chemistry Synthesis Methods
Government Ayurvedic College and Hospital
2017-2025
Tulane University
2021-2024
ABES Engineering College
2023
Deen Dayal Upadhyaya Gorakhpur University
1986-2021
All India Institute of Medical Sciences
2013-2015
Bundelkhand University
2012
SARS-CoV-2, the etiologic agent of COVID-19, uses ACE2 as a cell entry receptor. Soluble has been shown to have neutralizing antiviral activity but short half-life and no active transport mechanism from circulation into alveolar spaces lung. To overcome this, we constructed an ACE2-human IgG1 fusion protein with mutations in catalytic domain ACE2. A mutation ACE2, MDR504, significantly increased binding SARS-CoV-2 spike protein, well variant, vitro more potent viral neutralization plaque...
Several studies have indicated that human pre-implantation embryo-derived chorionic gonadotropin (hCG) may influence the implantation process by its action on endometrial epithelial and stromal cells. Despite reports indicating hCG acts these cells to affect production of several cytokines growth factors (e.g., MIF, IGF-I, VEGF, LIF, IL-11, GMCSF, CXL10 FGF2), our understanding integral paracrine interactions between during is very limited.In present study, we examined profile 48 in...
Increasing evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection impacts neurological function both acutely and chronically, even in the absence of pronounced distress. Developing clinically relevant laboratory mouse models neuropathogenesis SARS-CoV-2 is an important step toward elucidating underlying mechanisms SARS-CoV-2-induced dysfunction. Although various transgenic viral delivery methods have been used to study potential mice, use commonly...
Abstract: Chronic obstructive pulmonary disease (COPD) is a major global health problem. It results from chronic inflammation and causes irreversible airway damage. Levels of different serum cytokines could be surrogate biomarkers for lung function in COPD. We aimed to determine the levels COPD patients, association between cytokine various prognostic parameters, key pathways/networks involved stable In this study, 48 were examined by multiplex assays 30 subjects (control, n=9; COPD, n=21)....
Abstract Lung tissue resident memory (TRM) cells are thought to play crucial roles in lung host defense. We have recently shown that immunization with the adjuvant LTA1 (derived from A1 domain of E. coli heat labile toxin) admixed OmpX K. pneumoniae can elicit antigen specific Th17 TRM provide serotype independent immunity members Enterobacteriaceae family. However, upstream requirements generate these unclear. Single-cell RNA-seq showed vaccine-elicited expressed high levels IL-1R1,...
Illnesses associated with a certain lifestyle are referred to as illnesses. The biggest obstacles healthy existence altered choices brought about by more sedentary way of living, work demands, and competitive living. Diseases known disorders not spread from person or environment person, rather, they on unhealthy like smoking, binge drinking, poor diet, eating habits, inactivity, insomnia, psychological stress. Ayurveda is holistic science. Its primary goal keep people healthy, its secondary...
Purpose(Introduction): Diseases associated with a person's lifestyle are known as diseases. Condi-tions, including heart disease, stroke, obesity, and type II diabetes, mainly impact our way of life. This article focuses on the idea Hridroga (Heart Diseases) how to handle it from an Ayurvedic perspective, current updates so that one might avoid certain illnesses or treat them greater precision. Design/methodology/approach: The study is grounded in analysing ancient texts, Charaka Samhita...
Vataja Yonivyapada (Gynecological condition of vitiated Vata Dosha) applies to atrophic changes in women reproductive age, with signs and symptoms such as pain along irregular menstrual bleeding, which interferes daily chores, disrupts interpersonal relationships and, most importantly, reduces the quality life. It can be co-related regenerative reparative paps smear. Atrophic smear refers detection epithelial cells cervix is commonly seen postmenopausal but also occur younger for various...
SARS-CoV-2 variants, including B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) have displayed increased transmissibility and, therefore, been categorized as variants of concern (VOCs). The pervasiveness VOCs suggests a high probability future mutations that may lead to virulence. Prior reports shown VOC infection without expression human angiotensin converting enzyme-2 receptor (hACE2) in mice is possible. We sought understand if the can infect C57BL/6 hACE2 required for...
There is an urgent need for new treatment options carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae), which a common cause of life-threatening hospital- and community-acquired infections. Prophylactic or therapeutic vaccination may offer approach to control these infections, however, none has yet been approved human use. Here, we report the chemical synthesis outer core tetra- pentasaccharide derived from lipopolysaccharide K. pneumoniae. The oligosaccharides were equipped with...
The reactions of bis(cyclopentadienyl)titanium(IV) dichloride with Schiff bases derived by condensing 2‐ amino‐5‐phenyl‐1,3,4‐thiadiazole benzaldehyde (SPT), 4‐nitrobenzaldehyde (SNT), 4‐methoxybenzaldehyde (SMT), 2‐hydroxybenzaldehyde (SSTH) or 2‐hydroxyacetophenone (SATH) have been studied in refluxing tetrahydrofuran and complexes types [Cp 2 TiCl(SB)]Cl (SB= SPT, SNT SMT) Ti(SB′)]Cl (SB′H= SSTH SATH) isolated. Tentative structural conclusions are drawn for these reaction products based...
Conflicting results were yielded about the superiority of gonadotropin-releasing hormone agonist (GnRH-a) versus antagonist (GnRH-ant) protocols used in ovarian stimulation vitro fertilization (IVF) set-up. Reports also indicate that any single specific individual marker follicular fluid collected at time oocyte retrieval bears inconclusive value as a predictor quality.Simultaneous analyses large numbers cytokines, chemokines and growth factors perifollicular vascularity both for IVF program...
Human placental villous cytotrophoblasts exhibit relative externalization of negatively charged moieties to the outer leaflet plasma membrane during time syncytialization rendering their reactivity positively cationic antimicrobial peptides (CAMPs) window implantation and early placentation. Vaginal administration a synthetic CAMP, Ala8,13,18-magainin II amide (AMA) inhibited blastocyst placentation in monkeys. Furthermore, AMA resulted significant inhibition cell differentiation,...
The reactions of (eta(5) - C(5)H(5))(2)MCl(2) (M = Ti, Zr, or Hf) with mercaptoazoles (LH(2)), namely, bis(mercaptotriazoles), bis(mercap- tooxadiazoles), and bis(mercaptothiadiazoles) in 2 : 1 molar ratio, respectively, have been studied dry tetrahydrofuran the presence n-butylamine binuclear complexes type [{(eta C(5)H(5))(2) M}(2)(L)] Ti/Zr/Hf) are obtained. Tentative structural conclusions drawn for reaction products based upon elemental analysis, electrical conductance, magnetic moment,...
Heterocycles are very important scaffolds since many of them exhibit building blocks properties and good biological activities. Various chemical methods have been utilized for their synthesis out them, the environmentally benign approaches highly demanding in view importance green chemistry. There vast pieces literature available on sustainable multi-component synthetic approaches, but it is difficult a researcher to keep up with research. Therefore, review article heterocycle was required....
Abstract The reactions of CP2MCl2 (M = Ti or Zr) with hydrazones (H2L) derived from isatin and aromatic acid hydrazides (benzoic, 4—chlorobenzoic, 4—nitrobenzoic, 4—methoxybenzoic, picolinic, nicotinic isonicotinic) have been studied complexes the type [Cp2M(L)] were obtained. Tentative structural conclusions are drawn for reaction products based upon elemental analyses, electrical conductance, magnetic moments spectral (U.V.- Vis., IR, 1H NMR 13C NMR) data