A5100446607- Photonic Crystals and Applications
- Fluid Dynamics and Turbulent Flows
- Laser Material Processing Techniques
- Particle Dynamics in Fluid Flows
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Lattice Boltzmann Simulation Studies
- Circular RNAs in diseases
- Granular flow and fluidized beds
- Combustion and flame dynamics
- Fluid Dynamics and Vibration Analysis
- Advanced Fiber Laser Technologies
- Semiconductor Lasers and Optical Devices
- Climate variability and models
- Advanced Optical Imaging Technologies
- Phase-change materials and chalcogenides
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Aeolian processes and effects
- Nonlinear Optical Materials Studies
- HER2/EGFR in Cancer Research
- Fire dynamics and safety research
- Cancer-related gene regulation
Sir Run Run Shaw Hospital
2016-2024
Zhejiang University
2014-2024
State Key Laboratory of Modern Optical Instruments
2021-2024
State Key Laboratory on Integrated Optoelectronics
2024
Northeast Normal University
2024
Tsinghua University
2024
Second Affiliated Hospital of Zhejiang University
2021-2023
Beihang University
2023
Jilin University
2021-2022
Heilongjiang University of Chinese Medicine
2021-2022
Data-driven machine learning algorithms, random forests and artificial neural network (ANN), are used to establish the subgrid-scale (SGS) model for large-eddy simulation. A total of 30 flow variables examined as potential input features. priori tests indicate that ANN algorithm provides a better solution this regression problem. The relative importance is evaluated by two algorithms. It reveals gradient filtered velocity second derivative account vast majority importance. Besides, pattern...
Integrated photonics is attracting considerable attention and has found many applications in both classical quantum optics, fulfilling the requirements for ever-growing complexity modern optical experiments big data communication. Femtosecond (fs) laser direct writing (FLDW) an acknowledged technique producing waveguides (WGs) transparent glass that have been used to construct complex integrated photonic devices. FLDW possesses unique features, such as three-dimensional fabrication geometry,...
Background Global and national estimates on the epidemiology of aortic aneurysms are prerequisites for disease management policymaking. Based Burden Disease (GBD) 2019, this study aimed to discern global aneurysm burden by systematically analyzing demographic data mortality exploring attributable risks relevant factors. Methods The analyzed in were available Health Data Exchange (GHDx) online query tool. population our comprised individuals from 204 countries territories 1990 2019. estimated...
Abstract Inscribing functional micro-nano-structures in transparent dielectrics enables constructing all-inorganic photonic devices with excellent integration, robustness, and durability, but remains a great challenge for conventional fabrication techniques. Recently, ultrafast laser-induced self-organization engineering has emerged as promising rapid prototyping platform that opens up facile universal approaches various advanced nanophotonic elements attracted tremendous attention all over...
Abstract Advanced coloration methods are of pivotal importance in science, technology, and engineering. However, 3D structural colors that critical for emerging multidimensional information representation recording rarely achievable. Here, a facile voxel‐level programmable the bulk lithium niobate (LiNbO 3 ) crystal is reported. This achieved by engineering wavelength‐selective interference between ordinary (O) extraordinary (E) light matrix. To induce effective phase contrast O E...
Metal halide perovskite (MHP) structures that exhibit polarized photoluminescence (PL) have attracted significant interest in fabricating light field regulation elements for display, imaging, and information storage applications. We report a three-dimensional direct lithography of heterostructures controllable PL inside glass by laser-induced localized temperature engineering. The consisted oriented periodic (OPSs) MHP nanocrystals, the mechanism hierarchical distribution was illustrated....
The prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance concurrent systemic therapy. Cancer-associated fibroblasts (CAFs), as essential participators in the tumor microenvironment (TME), play a vital role progression. Thus, CAFs-targeting therapy is appealing for remodeling TME sensitizing GC conventional therapy.Amphiphilic SN38 prodrug polymeric micelles (PSN38) encapsulated hydrophobic esterase-responsive Triptolide...
Clear cell renal carcinoma (ccRCC) is one of the most prevalent cancers, and PANoptosis a distinct, inflammatory-programmed death regulated by PANoptosome. The essential regulators cancer occurrence progression are microRNAs (miRNAs). However, potential function PANoptosis-related (PRMs) in ccRCC remains obscure. This study retrieved samples from Cancer Genome Atlas database three Gene Expression Omnibus datasets. PRMs were recognized based on previous reports scientific literature....
Abstract Realizing general processing applicable to various materials by one basic tool has long been considered a distant dream. Fortunately, ultrafast laser–matter interaction emerged as highly universal platform with unprecedented optical phenomena and provided implementation paths for advanced manufacturing novel functionalities. Here, we report the establishment of three-dimensional (3D) focal-area interference field actively induced single laser in transparent dielectrics. Relying on...
Peripheral arterial disease (PAD) is a prevalent subtype of atherosclerotic cardiovascular diseases. It crucial to assess the PAD-related burden and its attributable risk factors. We use Global Burden Disease study 2019 database calculate incidence, prevalence, mortality, disability-adjusted life years (DALY), factors estimated annual percentage change. The PAD grows significantly with age accompanied by prominent heterogeneity between male female. Despite increase in absolute numbers from...
Abstract Highly efficient and programmable writing of multidimensional optical data is great value for next‐generation high‐throughput information technologies but has been rarely achieved. Here, a one‐step frame printing chromatic pixels in lithium niobate crystal by using single ultrafast laser pulse reported. In this strategy, phase superposition‐based spatial light modulation strategy applied to split into multiple son pulses with designated properties distribution patterns. It...
ABSTRACT Seismic near-fault ground motions with large amplitudes and long-period velocity pulses can cause significant damage to structures. In this study, a new stochastic model has been developed simulate pulse-like for specified earthquake scenarios. Wavelet packet transform is employed extract the pulse. The parameters of proposed are fitted Next Generation Attenuation (NGA)-West2 ground-motion database. A group predictive equations established predict occurrence time, frequency content,...
Abstract Predicting thermoelastic damping (TED) is crucial in the design of high Q micromechanical resonators. Circular plates are common elements microresonators. In past, some analytical models have been developed for TED circular microplate However, to obtain a simple expression, previous neglected temperature gradient along radial and circumferential directions, only heat conduction through thickness plate was considered. Thus cannot be used general purpose optimization This paper...
Abstract Tailoring ultrafast light–matter interaction as an enabler to create functional periodic crystalline patterns inside transparent dielectrics is of great scientific and technological significance but remains a tremendous challenge because plenty unclarified process details physical mechanisms. Here, dynamic laser‐induced continuous crystallization (CPC) generate self‐organized crystal arrays (CAs) the glass reported. The crystallite‐seeds induced by laser are revealed offer auxiliary...
We performed direct numerical simulations of decaying isotropic turbulence laden with finite-size particles using an immersed boundary method combined a soft-sphere collision model. The particle diameter is about 25 times the Kolmogorov length scale, and particle-to-fluid density ratio ranges from 10 to 1000. enhanced by heavy but suppressed light particles. radial spectral distributions main quantities are examined. enstrophy budget analyzed reveal how enhance dissipation rate. dependence...
Trastuzumab, the first antibody widely used in anti-HER2 targeted therapy, dramatically improved overall outcome of HER2 positive breast cancer patients. However, trastuzumab resistance emerged as a major problem its clinical application. In order to explore mechanisms underlying resistance, we performed RNA-Seq analyze gene expression variation resistant cell line. The sequencing result was then combined with relevant data TCGA database conduct co-expression analysis. We found series...
Point-particle direct numerical simulations of particle-laden flows have been conducted to investigate the complex coupling between inertial particles, buoyancy force, and strong shear in an unstably stratified turbulent boundary layer over a flat plate. Two-way particle-particle collisions, i.e., four-way coupling, are considered dilute gas-solid flows. The simulation results indicate that presence particles with diameter smaller than Kolmogorov length scale tends reduce thermal...