A5101597004- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Pain Mechanisms and Treatments
- Electrochemical sensors and biosensors
- Cerebrospinal fluid and hydrocephalus
- Botulinum Toxin and Related Neurological Disorders
- Advanced biosensing and bioanalysis techniques
- Mechanical Circulatory Support Devices
- Dye analysis and toxicity
- Dermatologic Treatments and Research
- Neonatal and fetal brain pathology
- Nerve injury and regeneration
- Oral and Maxillofacial Pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- TGF-β signaling in diseases
- Autophagy in Disease and Therapy
- Gas Sensing Nanomaterials and Sensors
- Advanced Nanomaterials in Catalysis
- Ginkgo biloba and Cashew Applications
- Ginseng Biological Effects and Applications
- Vagus Nerve Stimulation Research
- Acute Kidney Injury Research
- Cancer-related gene regulation
- Phytochemistry and Bioactive Compounds
Naval Medical Research Command
2016-2024
Henry M. Jackson Foundation
2019-2024
Second Affiliated Hospital of Jilin University
2020-2022
China Medical University
2017-2018
China Pharmaceutical University
2016-2017
First Hospital of China Medical University
2017
University of Maryland, Baltimore
2011-2014
Soochow University
2006-2011
Twin Cities Orthopedics
2011
University of Minnesota
2011
Background: It has been recently recognized that the descending serotonin (5-HT) system from rostral ventromedial medulla (RVM) in brainstem and 5-HT 3 receptor subtype spinal dorsal horn are involved enhanced pain facilitation after tissue nerve injury. However, mechanisms underlying activation of its contribution to remain unclear. Results: In present study, receptors by intrathecal injection a selective agonist SR 57227 induced glial hyperactivity, neuronal hyperexcitability...
Cell death has been reported in the CNS models of neuropathic pain (Sugimoto et al., 1990; Whiteside and Munglani, 2001; Scholz 2005; Fuccio 2009). In our present study, we examined effects spinal nerve ligation (SNL) on number neurons rostral ventromedial medulla (RVM), a brainstem region involved modulation nociception. rats receiving SNL, found that RVM decreased by 23% side ipsilateral to surgery. The loss was also associated with bilateral increase glia as well activation both...
Exposure to blast overpressure (BOP) activates a cascade of pathological processes including changes in intracranial pressure (ICP) and blood-brain barrier (BBB) permeability resulting traumatic brain injury (TBI). In this study the effect single multiple exposures at two intensities BOP on ICP BBB Sprague-Dawley rats was evaluated. Animals were exposed or three repetitive (separated by 0.5 h) BOPs 72 kPa 110 kPa. monitored continuously via telemetry for 6 days after exposure BOP. The...
Background: Epithelial to mesenchymal transition (EMT) is a major determinant of cancer metastasis and closely linked with TGF-β1. Intracellular proteins, including E. Cadherin, N. Cadherin Vimentin are directly related EMT that affect cell migration adhesion; on the other hand, non muscle myosin (NM) has central role in cytokinesis, adhesion. Objective: We aimed explore association TGF-β1 through regulation non-muscle II-A (NMII-A) its interaction Hexosamine Biosynthesis Pathway (HBP)....
The consequences of blast-induced traumatic brain injury (bTBI) on the blood-brain barrier (BBB) and components neurovascular unit are an area active research. In this study we assessed time course BBB integrity in anesthetized rats exposed to a single blast overpressure 130 kPa (18.9 PSI). permeability was measured vivo via intravital microscopy by imaging extravasation fluorescently labeled tracers (40 kDa 70 molecular weight) through pial microvasculature into parenchyma at 2-3 h, 1, 3,...
The long-term effects of exposure to blast overpressure are an important health concern in military personnel. Increase amyloid beta (Aβ) has been documented after non-blast traumatic brain injury (TBI) and may contribute neuropathology increased risk for Alzheimer's disease. We have shown that Aβ levels decrease following a low-intensity event. To further explore this observation, we examined the single 37 kPa (5.4 psi) on levels, production, clearance mechanisms acute (24 h) delayed (28...
Recent studies indicate that the descending serotonin (5-HT) system from rostral ventromedial medulla (RVM) in brainstem and 5-HT 3 receptor subtype spinal dorsal horn are involved enhanced pain facilitation after tissue nerve injury. However, mechanisms underlying activation of its contribution to remain unclear. In present study, by intrathecal injection a selective agonist, SR57227, induced glial hyperactivity, neuronal hyperexcitability, hypersensitivity rats. We found there was...
Falcarindiol (FAD) is a natural polyyne have been found in many food and dietary plants. It has to various beneficial biological activities. In this study, we demonstrated its anticancer function mechanism breast cancer cells. We that FAD preferentially induces cell death FAD-induced caspase-dependent. However, autophagy contribute the death. Blocking by either chemical inhibitors or genetic knockout of signaling component inhibits further mediated induction endoplasmic reticulum stress....
Exposure to blast overpressure may result in cerebrovascular impairment, including cerebral vasospasm. The mechanisms contributing this vascular response are unclear. aim of study was evaluate the relationship between and functional alterations microcirculation investigate potential underlying changes microstructure. Cerebrovascular responses were assessed sham- blast-exposed male rats at multiple time points from 2 h through 28 days after a single 130-kPa (18.9-psi) exposure. Pial cranial...
The glycocalyx is a proteoglycan–glycoprotein structure lining the luminal surface of vascular endothelium and susceptible to damage due blast overpressure (BOP) exposure. essential in maintaining structural functional integrity vasculature regulation cerebral blood flow (CBF). Assessment alterations density glycocalyx; its components (heparan sulphate proteoglycan (HSPG/syndecan-2), heparan (HS), chondroitin (CS)); CBF; effect hypercapnia on CBF was conducted at 2–3 h, 1, 3, 14, 28 days...
Blast-induced traumatic brain injury (bTBI) is a leading cause of injuries in recent military conflicts and it responsible for an increased number civilian casualties by terrorist attacks. bTBI includes variety neuropathological changes depending on the intensity blast overpressure (BOP) such as edema, neuronal degeneration, diffuse axonal damage, vascular dysfunction with neurological manifestations psychological cognitive abnormalities. Internal jugular vein (IJV) compression known to...
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is mainly used for reversible acute respiratory failure that difficult to correct with mechanical ventilation and other conventional measures or preparation of lung transplantation. Acute distress syndrome (ARDS) a typical clinical failure. The timing starting VV-ECMO in severe ARDS still face many controversies challenges. This paper we discuss the current feasible assessment methods when start ARDS, such as, optimization parameters,...
Keloid scarring is a type of fibroproliferative disease with high recurrence rate. However, no effective treatment currently available. Combined therapy recombinant lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase (Dm‑dNK) and prodrug has been widely studied used for cancer treatment. Due to the similarities between keloid scars tumors, aim present study was investigate efficacy Dm‑dNK/nucleoside analog system scars. Recombinant lentivirus expression Dm‑dNK suicide gene...
Robust and modular systems for T cell expansion have immense utilities clinical development immunoengineering research. In article 2101190, Che-Ming J. Hu co-workers demonstrate a photoactivated intracellular radical polymerization technique that transforms live dendritic cells into functional T-cell-stimulating biomaterial, which effectively enhances adoptive therapy against cancer in mice.