A5092507168- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Mitochondrial Function and Pathology
Universidad Autónoma de Madrid
2023-2025
Consejo Superior de Investigaciones Científicas
2024-2025
Centro de Biología Molecular Severo Ochoa
2023-2025
Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated are emerging as relevant players in the onset inflammaging and tissue senescence. Here, based on information provided by data, we present a flow cytometry panel allows identification cell subsets systematic larger analysis mice. We use this to evaluate at level mitochondrial senescence marks different subpopulations. Our identifies...
Abstract Neutrophils are the most abundant leukocytes in blood, with numbers further increasing age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 high neutrophil-to-lymphocyte ratio predicts all causes mortality elderly 2–5 . However, precise mechanisms driving enhanced neutrophil generation during ageing remain poorly understood. Here, we show that subset CD4 + T cells cytotoxic phenotype (CD4 CTLs)...