A5101508948- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Market Dynamics and Volatility
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Wound Healing and Treatments
- Epigenetics and DNA Methylation
- Global Energy Security and Policy
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Topic Modeling
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Optical Network Technologies
- Forensic Entomology and Diptera Studies
- Infectious Diseases and Mycology
- Global Energy and Sustainability Research
- Insect and Pesticide Research
- Burn Injury Management and Outcomes
- Photodynamic Therapy Research Studies
- Poxvirus research and outbreaks
- Insect behavior and control techniques
First People's Hospital of Foshan
2021-2025
Beijing University of Posts and Telecommunications
2024
Southwestern University of Finance and Economics
2024
Hubei University of Chinese Medicine
2022-2023
Shandong University
2022-2023
University of Washington
2023
Second Affiliated Hospital of Jilin University
2023
Hubei University
2023
China University of Geosciences
2023
Shenzhen Technology University
2022
The recent prevalence of monkeypox has led to the declaration a Public Health Emergency International Concern. Monkeypox lesions are typically ulcers or pustules (containing high titers replication-competent virus) in skin and mucous membranes, which allow virus transmit predominantly through intimate contact. Currently, effective clinical treatments for lacking, strategies blocking transmission fraught with drawbacks. Herein, this work constructs biomimetic nanotemplate (termed TBD@M NPs)...
Injudicious or inappropriate use of antibiotics has led to the prevalence drug-resistant bacteria, posing a huge menace global health. Here, self-assembled aggregation-induced emission (AIE) nanosphere (AIE-PEG1000 NPs) that simultaneously possesses near-infrared region II (NIR-II) fluorescence emissive, photothermal, and photodynamic properties is prepared using multifunctional AIE luminogen (AIE-4COOH). The AIE-PEG1000 NPs were encapsulated with teicoplanin (Tei) ammonium bicarbonate (AB)...
Abstract Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic requires both generation ROS to inhibit bacteria subsequent reduction levels initiate promote tissue regeneration, which calls for more intelligent regulation dressing system. Hence, dual‐layered hydrogel (Dual‐Gel) tailored repair is designed: inner layer (Gel 2) first responds bacterial hyaluronidase (Hyal)...
Abstract As a high‐risk trauma, deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent infections. In this study, we developed simultaneous strategy for burn wounds treatment using functional nanovesicles with antibacterial remodeling properties, delivered via click‐chemistry hydrogel. An aggregation‐induced emission photosensitizer of 4‐(2‐(5‐(4‐(diphenylamino)phenyl)thiophen‐2‐yl)vinyl)‐1‐(2‐hydroxyethyl) pyridin‐1‐ium bromide (THB)...
Abstract Infected burn wounds are characterized by persistent drug‐resistant bacterial infection coupled with an inflammatory response, impeding the wound‐healing process. In this study, intelligent nanoparticle system (CCM+TTD@ZIF‐8 NPs) was prepared using curcumin (CCM), aggregation‐induced emission luminogens (TTD), and ZIF‐8 for infection‐induced wound healing. The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging pH response‐guided...
Increasing evidence has demonstrated that pyroptosis, a type of inflammatory programmed cell death, plays an important role in the pathogenesis and progression gastric cancer. However, it remains unclear whether pyroptosis-related long non-coding RNAs (lncRNAs) can be used to predict diagnosis prognosis adenocarcinoma. This study aimed evaluate test lncRNA signature associated with pyroptosis as prognostic tool for stomach adenocarcinoma (STAD) ascertain their immune value. Relative...
Skin cutaneous melanoma (SKCM) is a common malignant skin cancer with high mortality and recurrence rates. Although the mRNA vaccine promising strategy for treatment, its application against SKCM remains confusing. In this study, we employed computational bioinformatics analysis to explore SKCM-associated antigens an suitable populations vaccination. Gene expression clinical data were retrieved from GEO TCGA. The differential levels prognostic index of selected computed via GEPIA2,while...
SHARPIN, as a tumor-associated gene, is involved in the metastatic process of many kinds tumors. Herein, we studied function Shank-associated RH domain interacting protein (SHARPIN) melanoma metastasis and relevant molecular mechanisms. We found that SHARPIN expression was increased tissues activated proliferation, migration, invasion vitro vivo, resulting poor prognosis disease. Functional analysis demonstrated promoted migration by regulating Ras-associated protein-1(Rap1) its downstream...
Skin cancer is one of the most common types cancer. An accessible tool to public can help screening for malign lesion. We aimed develop a deep learning model classify skin lesion using clinical images and meta information collected from smartphones. A neural network was developed with two encoders extracting image data metadata. multimodal fusion module intra-modality self-attention inter-modality cross-attention proposed effectively combine features features. The trained on tested dataset...
Abstract Background Utrophin ( UTRN ), as a tumor suppressor gene, is involved in various cancer progression. The function of the melanoma process and related molecular mechanisms are still unclear. Herein, we studied growth relevant mechanisms. Methods Using GEO database UCSC Xena project, compared expression non-cancerous tissues. Immunohistochemistry (IHC) staining, qRT-PCR Western Blot (WB) were performed to evaluate clinical samples. A total 447 cases with data, patient characteristics...
Objectives High turnover intention can exacerbate the workforce shortage of nurses. This study aimed to determine level public hospital nurses in China and its associated factors. Methods A cross-sectional questionnaire survey 2,863 was conducted 48 hospitals across six provinces mainland China, measuring sociodemographic (gender, age, marital status, monthly basic salary) work characteristics (professional title, workload, night sleep deprivation, workplace violence) respondents, their...
A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined treatment. Existing evidence indicates the immune system plays an important role in occurrence and development keloid. However, there still lack research on immune-related signatures Here we identified explored their pathological mechanisms. Transcriptomic datasets (GSE7890, GSE92566, GSE44270) normal skin tissues were obtained from Gene Expression Omnibus database. The overlap differentially...
Abstract Ferroptosis is a novel form of cell death that plays key role in several diseases, including inflammation and tumours; however, the ferroptosis‐related genes diabetic foot remains unclear. Herein, foot‐related were downloaded from Gene Expression Omnibus ferroptosis database (FerrDb). The least absolute shrinkage selection operator regression algorithm was used to construct related risk model, differentially expressed analysed through immune infiltration. Finally, we identified...
Osteoporosis has become a world-wide health problem. As promising intervention, mechanical strain is considered to be an important factor in bone remodeling. However, the underlying mechanisms are still not clarified clearly. In present study, we aim investigate possible mechanism by which stimulation induces osteogenic differentiation of mesenchymal stem cells (BMSCs) from ovariectomized rats (OVX BMSCs). The results demonstrated that intermittent (IMS) promoted OVX BMSCs activating...
Abstract Background Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential as a therapeutic target. Stem cell-derived extracellular vesicles (EVs) are increasingly being developed nano-scale drug carriers. The aim this study was to determine ferroptosis pathogenesis diabetic wound healing evaluate effects coenzyme Q10 (Q10)-stimulated exosmes derived from mesenchymal stem cells (MSCs). Methods Human keratinocytes (HaCaTs) were exposed...
The tumorigenesis of skin cutaneous melanoma (SKCM) remains unclear. tumor microenvironment (TME) is well known to play a vital role in the onset and progression SKCM. However, dynamic mechanisms immune regulation are insufficient. We conducted comprehensive analysis cell infiltration TME. Based on differentially expressed genes (DEGs) clusters grouped by status, set hub related clinical prognosis SKCM was explored. Methods: analyzed two independent cohorts assessed relationship between...
Abstract Skin cutaneous melanoma (SKCM) is one of the most destructive skin malignancies and has attracted worldwide attention. However, there a lack prognostic biomarkers, especially tumour microenvironment (TME)‐based biomarkers. Therefore, an urgent need to investigate TME in SKCM, as well identify efficient biomarkers for diagnosis treatment SKCM patients. A comprehensive analysis was performed using samples from The Cancer Genome Atlas normal Genotype‐Tissue Expression. scores were...
Providing protection against aggregation and guiding hydrophobic precursors through the mitochondria's intermembrane space, this protein functions as a chaperone-like protein. SLC25A12 is imported by TIMM8 result of its interaction with TIMM13. In spite this, it still unknown how TIMM13 interacts skin cutaneous melanoma (SKCM) tumor-infiltrating lymphocytes (TILs).Aberrant expression in SKCM clinical outcome was evaluated help multiple databases, including Xiantao tool...
Skin cutaneous melanoma (SKCM) is a highly aggressive and resistant cancer with immense metabolic heterogeneity. Here, we performed comprehensive examination of the diverse signatures SKCM based on non-negative matrix factorization (NMF) categorization, clustering into three distinct subtypes (C1, C2, C3). Next, evaluated metadata sets signatures, prognostic values, transcriptomic features, tumor microenvironment immune infiltration, clinical drug sensitivity, immunotherapy response compared...
Gene mutations play an important role in tumor progression. This study aimed to identify genes that were mutated colorectal cancer (CRC) and explore their biological effects prognostic value CRC patients. We performed somatic mutation analysis using data sets from The Cancer Genome Atlas International Consortium, identified FREM2 had the highest frequency patients with colon adenocarcinoma (COAD). COAD divided into FREM2-mutated type (n = 36) FREM2-wild 278), a Kaplan-Meier survival curve...
Abstract Keloids are formed due to abnormal hyperplasia of the skin connective tissue. We explored relationship between N6‐methyladenosine (m6A)‐related genes and keloids. The transcriptomic datasets (GSE44270 GSE185309) keloid normal tissues samples were obtained from Gene Expression Omnibus database. constructed m6A landscape verified corresponding using immunohistochemistry. extracted hub for unsupervised clustering analysis protein–protein interaction (PPI) network; gene ontology...