A5070883445- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Pneumothorax, Barotrauma, Emphysema
- Microbial infections and disease research
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory viral infections research
- Non-Invasive Vital Sign Monitoring
- Family and Patient Care in Intensive Care Units
- Clinical practice guidelines implementation
- Obstructive Sleep Apnea Research
- Retinal and Optic Conditions
- Meta-analysis and systematic reviews
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
- Nosocomial Infections in ICU
Centre Hospitalier Universitaire de Tours
2020-2023
Inserm
2020-2023
Hôpitaux Universitaires de Strasbourg
2022-2023
Clinical Investigation Center Plurithematic Tours
2020-2023
Université de Tours
2020-2022
French Clinical Research Infrastructure Network
2021-2022
Adaptation Biologique et Vieillissement
2021-2022
Centre d'Étude des Pathologies Respiratoires
2020-2021
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the is a key feature ARDS pathophysiology. However, cellular actors involved COVID-19–driven are poorly understood. Here, blood and airways of severe patients, we serially analyzed unconventional T cells, heterogeneous class lymphocytes (MAIT, γδT, iNKT cells) with potent antimicrobial regulatory functions. Circulating cells...
Abstract Background Awake prone positioning (APP) improves oxygenation in coronavirus disease (COVID-19) patients and, when successful, may decrease the risk of intubation. However, factors associated with APP success remain unknown. In this secondary analysis, we aimed to assess whether can reduce intubation rate COVID-19 and focus on success. Methods multicenter randomized controlled trial, conducted three high-acuity units, randomly assigned COVID-19-induced acute hypoxemic respiratory...
BACKGROUND AND PURPOSE 255: Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development novel antibiotics. However, phage compassionate use so far, resulting from lack adequate studies in relevant pharmacological models. We used pig model caused by P. that recapitulates essential features human disease study antimicrobial efficacy nebulized-phage...
Abstract Covid-19 can induce lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the is a key feature ARDS pathophysiology. However, cellular actors Covid-19-driven are poorly understood. Here, we dynamically analyzed biology of innate T cells, heterogeneous class (MAIT, γδT and iNKT cells) lymphocytes, presenting potent anti-infective regulatory functions. Patients presented compartmentalized...
Introduction Prone positioning (PP) is an effective first-line intervention to treat patients with moderate severe acute respiratory distress syndrome (ARDS) receiving invasive mechanical ventilation, as it improves gas exchanges and reduces mortality. The use of PP in awake spontaneous breathing ARDS secondary COVID-19 was reported improve oxygenation few retrospective trials small sample size. High-level evidence for hypoxaemic still lacking. Methods analysis protocol this meta-trial a...
La mise en décubitus ventral des patients non intubés a connu un engouement exceptionnel durant la pandémie COVID-19. Dans cette au point, après avoir couvert le rationnel physiopathologique sous-tendant pratique, les indications, contre-indications ainsi que faisabilité sont abordées. Les données scientifiques issues de nombreuses études observationnelles mais aussi d’essais randomisés passées revues avant d’envisager aspects pratiques réanimation. Des fortes suggèrent bénéfice termes...
Background and Purpose. Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development novel antibiotics. However, phage compassionate use so far, resulting from lack adequate studies in relevant pharmacological models. We used pig model VAP caused by P. that recapitulates essential features human disease study antimicrobial efficacy nebulized-phage...