A5036034865- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Trauma and Emergency Care Studies
- Minimally Invasive Surgical Techniques
- Bariatric Surgery and Outcomes
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and Mental Health
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Spine and Intervertebral Disc Pathology
- Infection Control and Ventilation
- Pneumothorax, Barotrauma, Emphysema
- Interprofessional Education and Collaboration
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Family and Patient Care in Intensive Care Units
- Acute Kidney Injury Research
- Inhalation and Respiratory Drug Delivery
- Simulation-Based Education in Healthcare
Ollscoil na Gaillimhe – University of Galway
2020-2025
University Hospital Galway
2020-2025
META Group
2025
Analysis Group (United States)
2025
Saolta University Health Care Group
2020-2023
University of Canberra
2020-2022
Galway Clinic
2021
Prince Charles Hospital
2021
Universidade Estadual de Campinas (UNICAMP)
2020
Universidade de São Paulo
2020
Aims Inhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale that warrants urgent investigation of its therapeutic potential in patients with COVID‐19. UFH antiviral effects prevents the SARS‐CoV‐2 virus' entry into mammalian cells. In addition, significant anti‐inflammatory anticoagulant properties, which limit progression lung injury vascular pulmonary thrombosis. Methods The INHALEd HEParin for treatment hospitalised COVID‐19 (INHALE‐HEP) metatrial...
Nebulised unfractionated heparin may attenuate COVID-19 ARDS by reducing pulmonary microvascular thrombosis, blocking SARS-CoV-2 entry into cells, and decreasing lung inflammation. patients with a raised D-dimer have areas of hypoperfusion on CT perfusion scans the increased mortality risk. This was phase Ib/IIa open-label multi-centre, randomised controlled trial. The study designed to evaluate whether nebulised decreased concentrations, safety as co-primary outcome. Forty were recruited,...
Purpose This study explores the millennial perceptions of cause-related marketing (CRM) in international markets through lens an ethical continuum. Literature gaps exist our understanding marketing, ethics and millennials context, with few studies offering insights into successful CRM campaigns developed vs developing countries. Previous have yielded differing responses based on culture, sociodemographic consumer perceptions. Design/methodology/approach An exploratory qualitative research...
There is significant interest in the potential for nebulised unfractionated heparin (UFH), as a novel therapy patients with COVID-19 induced acute hypoxaemic respiratory failure requiring invasive ventilation. The scientific and biological rationale stems from evidence extensive activation of coagulation resulting pulmonary microvascular thrombosis pneumonia. Nebulised delivery to lung may limit alveolar fibrin deposition thereby progression injury. Importantly, laboratory studies show that...
Introduction Prone positioning (PP) is an effective first-line intervention to treat patients with moderate severe acute respiratory distress syndrome (ARDS) receiving invasive mechanical ventilation, as it improves gas exchanges and reduces mortality. The use of PP in awake spontaneous breathing ARDS secondary COVID-19 was reported improve oxygenation few retrospective trials small sample size. High-level evidence for hypoxaemic still lacking. Methods analysis protocol this meta-trial a...
COVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological features. These include diffuse alveolar damage extensive pulmonary coagulation activation. This results in fibrin deposition microvasculature, leading to formation hyaline membranes air sacs. Well-conducted clinical trials have found that nebulised heparin limits deposition, attenuates progression ARDS, hastens recovery and safe non-COVID ARDS....
Summary Intrathecal morphine is an analgesic option for major hepatopancreaticobiliary procedures but associated with a risk of respiratory depression. We hypothesised that postoperative low‐dose naloxone infusion would reduce the incidence depression without increase in pain scores. Patients scheduled open surgery and who were receiving 10 μg.kg −1 intrathecal eligible inclusion. allocated randomly to receive 5 .h (naloxone group) or saline at identical rate (control until morning after...
Introduction The first case of COVID-19 in Ireland was diagnosed on 29 February 2020. Within the same week, our Department Anaesthesia and Critical Care at University Hospital Galway began to tackle educational challenge by developing an situ interprofessional simulation programme prepare staff for impending outbreak. Principles approaches used simulation-based training We describe principles applied identify core system engineering objectives healthcare workers (HCWs) infection control,...
Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for respiratory depression at doses required currently limits its clinical use. The use low-dose, prophylactic naloxone infusion intrathecally may significantly reduce depression. NAPRESSIM trial aims to answer this question. ‘The prevent with morphine’ an investigator-led, single-centre, randomised, double-blind,...
<title>Abstract</title> <bold>Background</bold> Obesity is a rapidly growing global health concern. Limited long-term success of diet, behavioural modification and medical therapy have led to the increased performance bariatric surgery. Laparoscopic sleeve gastrectomy, which permanently reduces size stomach, has been shown cause considerable weight loss, as well improving or even eliminating obesity related comorbidities such diabetes, obstructive sleep apnoea hypertension. Unfortunately,...
Inhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale that warrants urgent investigation of its therapeutic potential in patients with COVID-19. UFH antiviral effects prevents the SARS-CoV-2 virus’ entry into mammalian cells. In addition, significant anti-inflammatory anti-coagulant properties, which limit progression lung injury vascular pulmonary thrombosis. Methods intervention The INHALEd HEParin for treatment hospitalised COVID-19 (INHALE-HEP)...
Abstract Background Coronavirus disease 2019 (COVID-19) has exposed the disproportionate effects of pandemics on frontline workers and ethical imperative to provide effective prophylaxis. We present a model for pragmatic randomised controlled trial (RCT) that utilises Bayesian methods rapidly determine efficacy or futility prophylactic agent. Methods initially planned undertake multicentre, phase III, parallel-group, open-label RCT, if hydroxychloroquine (HCQ) taken once week was in...