A5064024343- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Tracheal and airway disorders
- Nosocomial Infections in ICU
- Immune responses and vaccinations
- Blood Coagulation and Thrombosis Mechanisms
- Hemodynamic Monitoring and Therapy
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antibiotic Resistance in Bacteria
Instituto de Salud Carlos III
2022-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017-2024
Institute of Research and Innovation Parc Tauli
2015-2024
Universitat Autònoma de Barcelona
2017-2024
Corporació Sanitària Parc Taulí
2019-2024
Centro de Investigación Biomédica en Red
2020-2022
University of Canberra
2020-2022
Universidade Estadual de Campinas (UNICAMP)
2020
Universidade de São Paulo
2020
University of Portsmouth
2020
Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed compare various methods estimation ratio in patients acute respiratory distress syndrome (ARDS) determine their independent values predicting death at day 30. The present is a post hoc analysis prospective observational cohort ICUs two tertiary care hospitals...
Objective Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating inflammatory response coagulation cascade lungs. Anti-coagulants may be helpful treatment ARDS. This study investigated effects nebulized heparin on alveolar limiting lung an animal model injury (ALI). Methods Rats were randomized to four experimental groups. In three groups, ALI was induced by intratracheal instillation lipopolysaccharide (LPS) at...
Abstract Background The animal experimental counterpart of human acute respiratory distress syndrome (ARDS) is lung injury (ALI). Most models ALI involve reproducing the clinical risk factors associated with ARDS, such as sepsis or acid aspiration; however, none these fully replicates ARDS. Aim To compare different ALI, based on direct indirect mechanisms injury, to characterize a model which more closely could reproduce phase Materials and methods Adult male Sprague-Dawley rats were...
Aims Inhaled nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale that warrants urgent investigation of its therapeutic potential in patients with COVID‐19. UFH antiviral effects prevents the SARS‐CoV‐2 virus' entry into mammalian cells. In addition, significant anti‐inflammatory anticoagulant properties, which limit progression lung injury vascular pulmonary thrombosis. Methods The INHALEd HEParin for treatment hospitalised COVID‐19 (INHALE‐HEP) metatrial...
Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However, intravenous (IV) often achieve suboptimal pulmonary concentrations. We therefore aimed evaluate the effect inhaled amikacin (AMK) plus IV meropenem (MEM) on bactericidal efficacy in a swine model monolateral MDR P. pneumonia.We ventilated 18 pigs for up 102 h. At 24 h after bacterial challenge, animals were randomized receive 72 either...
Introduction Hypercapnia is developed in patients with acute and/or chronic respiratory conditions. Clinical data concerning hypercapnia and infections interaction limited.
Acute respiratory distress syndrome (ARDS) is a clinical characterized by acute hypoxemic failure. Pneumonia and sepsis are the most common causes, turning ARDS into critical public health problem. Despite recent advances in pharmacological strategies, trials have not demonstrated reduction ARDS‐associated mortality. This part connected to singularity of pulmonary physiological barrier, which hampers drug delivery, specifically at distal areas. To this aim, use polymeric nanocarriers as...
In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved beneficial effects heparin pulmonary coagulopathy, which derive from its anti-inflammatory activities, although it is uncertain whether works. Understanding specific effect unfractioned on cell lung populations would be interest to our knowledge about pathways treat ARDS. current study,...
The use of cell therapies has recently increased for the treatment pulmonary diseases. Mesenchymal stem/stromal cells (MSCs) and alveolar type II (ATII) are main cell-based used acute respiratory distress syndrome (ARDS). Many pre-clinical studies have shown that both generate positive outcomes; however, differences in efficiency MSCs or ATII reducing lung damage remains to be studied. We compared potential therapies, administering them using same route dose equal time points a sustained...
Nearly four million yearly deaths can be attributed to respiratory diseases, prompting a huge worldwide health emergency. Additionally, the COVID-19 pandemic's death toll has surpassed six million, significantly increasing disease morbidity and mortality rates. Despite recent advances, it is still challenging for many drugs homogeneously distributed throughout lungs, specifically reach lower tract with an accurate sustained dose minimal systemic side effects. Engineered nanocarriers provide...
Abstract Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change classification treatment response disease evolution. We aimed evaluate when clustered in more than 1 group, and how they clustering using data baseline day 3, prognosis their evolution...
Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) have been proposed as an alternative to live-cell administration for Acute Respiratory Distress Syndrome (ARDS). MSC-EVs can be chiefly influenced by the environment which MSCs are exposed. Here, lipopolysaccharide (LPS) priming of was used a strategy boost natural therapeutic potential EVs in acute lung injury (ALI).
Sepsis is a serious, heterogeneous clinical entity produced by severe and systemic host inflammatory response to infection. Methotrexate (MTX) folate-antagonist that induces the generation of adenosine also inhibits JAK/STAT pathway; MTX it widely used as an anti-inflammatory drug control immune system.
One of the main limitations in vitro studies on lung diseases is difficulty maintaining type II phenotype alveolar epithelial cells culture. This fact has previously been related to translocation mechanosensing Yes-associated protein (YAP) nuclei and Rho signaling pathway. In this work, we aimed culture subculture primary extracellular matrix lung-derived hydrogels assess their suitability for maintenance. Cells cultured formed monolayers maintained a longer time as compared with those...