A5038945094- COVID-19 and healthcare impacts
- Diversity and Career in Medicine
- Healthcare Systems and Challenges
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Cancer-related gene regulation
- Infectious Diseases and Tuberculosis
- Metabolism and Genetic Disorders
- Global Health Workforce Issues
- Ethics and Legal Issues in Pediatric Healthcare
- Vitamin C and Antioxidants Research
- Viral gastroenteritis research and epidemiology
- Infective Endocarditis Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Cancer Cells and Metastasis
- Palliative Care and End-of-Life Issues
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Clostridium difficile and Clostridium perfringens research
KK Women's and Children's Hospital
2021
Wellcome Sanger Institute
2015-2016
Duke-NUS Medical School
2013
Institute of Molecular and Cell Biology
2012
Clostridium difficile is a leading cause of antibiotic-associated diarrhea, significant animal pathogen, and worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA TcdB, which are considered to be the primary virulence factors. Understanding role that these toxins play in disease essential for rational design urgently needed new therapeutics. However, their relative contributions remain contentious. Using three different models, we show TcdA(+) TcdB(-)...
The transcription factor RUNX3 functions as a tumor suppressor in the gastrointestinal epithelium, where its loss is an early event carcinogenesis. While acts concurrently mediator of TGF-β signaling and antagonist Wnt, cellular changes that follow their contribution to tumorigenicity are not fully understood. Here, we report Runx3 gastric epithelial cells results spontaneous epithelial-mesenchymal transition (EMT). This produces tumorigenic stem cell-like subpopulation, which remarkably...
ABSTRACT Mice harboring a mutation in the gene encoding gastric intrinsic factor (Gif), protein essential for absorption of vitamin B 12 /cobalamin (Cbl), have potential as model to explore role vitamins infection. The levels Cbl blood Gif tm1a/tm1a mutant mice were influenced by maternal genotype, with offspring born heterozygous (high Cbl, F 1 ) mothers exhibiting significantly higher serum level than those homozygous (low 2 equivalents. Low correlated susceptibility an infectious...
As advances in medical technology are constantly re-defining the lower limit of newborn viability, practice withholding/withdrawing treatment neonatal care is increasingly prevalent. Now more than ever, physicians working intensive units have to face ethical dilemma terminating neonates' life support, sometimes against parents' desire. Traditionally and legally, parents duty make decisions on behalf their infants because they ones whom consequences matter most. Physicians, other hand, often...
Dear Editor, The ongoing COVID-19 pandemic is likely to have far-reaching implications on residency training under the competency-based system, Accreditation Council for Graduate Medical Education I (ACGME-I). caused considerable disruption due longer infectious period and greater asymptomatic transmissibility.1 This study aims identify impact of paediatrics, obstetrics
Dear Editor, The ongoing COVID-19 pandemic is likely to have far-reaching implications on residency training under the competency-based system, Accreditation Council for Graduate Medical Education I (ACGME-I). caused considerable disruption due longer infectious period and greater asymptomatic transmissibility.1 This study aims identify impact of paediatrics, obstetrics