A5008891722- Diabetes and associated disorders
- Pancreatic function and diabetes
- Respiratory viral infections research
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Virus-based gene therapy research
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- GDF15 and Related Biomarkers
- Antimicrobial Peptides and Activities
- Molecular Biology Techniques and Applications
- Parvovirus B19 Infection Studies
- Genetic Neurodegenerative Diseases
- Bacterial Infections and Vaccines
- Microbial infections and disease research
- Viral Infectious Diseases and Gene Expression in Insects
- Growth Hormone and Insulin-like Growth Factors
- Gynecological conditions and treatments
- Pneumonia and Respiratory Infections
- Uterine Myomas and Treatments
- Diabetes Management and Research
- Endometriosis Research and Treatment
- Diabetes Treatment and Management
- Birth, Development, and Health
Uppsala University
2016-2024
Vanderbilt University Medical Center
2022
Science for Life Laboratory
2017-2018
Profil Institute for Metabolic Research
2016
Abstract The muscle RING-finger protein-1 (MuRF1) is an E3 ubiquitin ligase expressed in skeletal and cardiac tissues it plays important roles remodeling. Upregulation of MuRF1 gene transcription participates atrophy, on contrary downregulation protein expression leads to hypertrophy. point mutations have been found generate aggregate myopathies defined as disorder characterized by accumulation fibers. We discovered that turned out be also a target for new post-translational modification...
Achieving safe and protective vaccination against respiratory syncytial virus (RSV) in infants calves has proven a challenging task. The design of recombinant antigens with conformation close to their native form particles is major breakthrough. We compared two subunit vaccines, the bovine RSV (BRSV) pre-fusion F (preF) alone or nanorings formed by nucleoprotein (preF+N). PreF N proteins are potent antigenic targets for neutralizing antibodies T cell responses, respectively. To tackle...
Aims To investigate the effect of sequential treatment escalation with empagliflozin and linagliptin on laboratory markers α‐ β‐cell function in people type 2 diabetes mellitus ( T2DM ) insufficiently controlled metformin monotherapy. Research design methods A total 44 received 25 mg for a duration 1 month an open‐label fashion (treatment period [ TP1 ]). Thereafter, they were randomized to double‐blind add‐on therapy 5 or placebo TP2 ]) additional month. was assessed using standardized...
Abstract Samples in biobanks are generally preserved by formalin-fixation and paraffin-embedding (FFPE) and/or optimal cutting temperature compound (OCT)-embedding subsequently frozen. Mass spectrometry (MS)-based analysis of these samples is now available via developed protocols, however, the differences results with respect to preservation methods needs further investigation. Here we use bladder urothelial carcinoma tissue two different tumor stages (Ta/T1—non-muscle invasive cancer...
The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either (i) BRSV pre-fusion protein (PreF) MontanideTM ISA61 VG (ISA61, n = 6), (ii) lacking SH gene (ΔSHrBRSV, (iii) commercial vaccine (CV, or injected alone (n 6). All challenged 92 days later euthanized 13 post-infection. Based on...
The immune system of healthy individuals is capable regulating autoimmunity through multiple mechanisms. In Type 1 Diabetes (T1D) we recently discovered natural IgM, although present at normal levels, unable to perform its immunoregulatory function. Treating diabetic mice with IgM from donors led reversal disease without depletion. To investigate the therapeutic potential a human preparation administered an IgM-enriched immunoglobulin called Pentaglobin. Administration Pentaglobin therapy...
Asthma is a chronic respiratory disease with one of the largest numbers cases in world; thus, constant investigation and technical development are needed to unravel underlying biochemical mechanisms. In this study, we aimed develop nano-DESI MS method for vivo characterization cellular metabolome. Using air-liquid interface (ALI) cell layers, studied role Interleukin-13 (IL-13) on differentiated lung epithelial cells acting as tissue model. We demonstrate feasibility monitoring basal-apical...
To determine the impact of autoimmunity in absence glycemic alterations on pregnancy type 1 diabetes (T1D).