A5071357910- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Antimicrobial Resistance in Staphylococcus
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
University of Florida
2018-2023
Gainesville Obstetrics & Gynecology
2021
Abstract Escherichia coli ( E. ) cells are present in fecal materials that can be the main source for disease‐causing agents water. As a result, is recommended as water quality indicator. We have developed an innovative platform to detect monitoring on-site by integrating paper-based sample preparation with nucleic acid isothermal amplification. The carries out bacterial lysis and DNA enrichment onto paper pad through ball-based valves fluid control, no need of laboratory equipment, followed...
Bacterial biofilms are surface-attached communities comprised of nonreplicating persister cells housed within a protective extracellular matrix. Biofilms display tolerance toward conventional antibiotics, occur in ∼80% infections, and lead to >500000 deaths annually. We recently identified halogenated phenazine (HP) analogues which demonstrate biofilm-eradicating activities against priority pathogens; however, the synthesis phenazines presents limitations. Herein, we report refined HP...
During infection, bacteria use an arsenal of resistance mechanisms to negate antibiotic therapies. In addition, pathogenic form surface-attached biofilms bearing enriched populations metabolically dormant persister cells. Bacteria develop in response insults; however, nonreplicating are innately tolerant all classes antibiotics. As such, molecules that can eradicate antibiotic-resistant and antibiotic-tolerant importance. Here, we report modular synthetic routes fluorine-containing...
We have designed, synthesized and evaluated a new ether-linked halogenated phenazine-quinone prodrug model that demonstrates antibacterial activities against pathogenic bacteria.
Pathogenic bacteria have devastating impacts on human health as a result of acquired antibiotic resistance and innate tolerance. Every class our current arsenal was initially discovered growth-inhibiting agents that target actively replicating (individual, free-floating) planktonic bacteria. Bacteria are notorious for utilizing diversity mechanisms to overcome the action conventional therapies forming surface-attached biofilm communities enriched in (non-replicating) persister cells. To...