A5102985856- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Cardiac Arrest and Resuscitation
- Pharmacogenetics and Drug Metabolism
- Acute Lymphoblastic Leukemia research
- Neurogenetic and Muscular Disorders Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotic Use and Resistance
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Ocular and Laser Science Research
- Immune responses and vaccinations
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Imaging and Diagnostics
- Hereditary Neurological Disorders
- Lipid metabolism and disorders
- Ion channel regulation and function
- Sepsis Diagnosis and Treatment
National Cancer Center
2025
National Cancer Center
2023-2024
Green Cross Laboratories (South Korea)
2024
GL PharmTech (South Korea)
2024
Green Cross (South Korea)
2014-2020
Johns Hopkins University
2019
New Generation University College
2014
Seoul National University Hospital
2009-2014
Kangwon National University
2014
Konkuk University
2013-2014
ObjectiveTo diagnose invasive pulmonary aspergillosis (IPA), galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (BALF) is widely used. However, the utility of proximal airway GM test (from induced sputum tracheal aspirate) has not been well elucidated.MethodsIn this retrospective cohort study, we evaluated diagnostic performance diagnosis IPA including COVID-19 associated (CAPA). Between January 2022 and 2023, patients who had tested for with clinical suspicion...
ABSTRACT Introduction Duchenne and Becker muscular dystrophies (DMD BMD) are allelic X‐linked recessive muscle diseases caused by mutations in the large complex dystrophin gene. Methods We analyzed gene 507 Korean DMD/BMD patients multiple ligation‐dependent probe amplification direct sequencing. Results Overall, 117 different deletions, 48 duplications, 90 pathogenic sequence variations, including 30 novel were identified. Deletions duplications accounted for 65.4% 13.3% of...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern have been emerging. However, knowledge temporal and spatial dynamics SARS-CoV-2 is limited. This study characterized evolution in immunosuppressed patients with long-term shedding for 73–250 days, without specific treatment. We conducted whole-genome sequencing 27 serial samples, including 26 samples collected from various anatomic sites two the first positive sample patient 2's mother. analysed intrahost...
A newborn screening (NBS) program has been utilized to detect asymptomatic newborns with inherited metabolic diseases (IMDs). There have some bottlenecks such as false-positives and imprecision in the current NBS tests. To overcome these issues, we developed a multigene panel for IMD testing investigated utility of our integrated model routine environment. We also evaluated genetic epidemiologic characteristics IMDs Korean population.In total, 269 dried blood spots positive results from...
Multiple epiphyseal dysplasia (MED) is a genetically heterogeneous group of diseases characterized by variable degrees abnormality primarily involving the hip and knee joints. The purpose this study was to investigate frequency mutations in individuals with clinical radiographic diagnosis MED test hypothesis that characteristic radiological findings may be helpful predicting gene responsible. radiographs 74 Korean patients were evaluated panel skeletal experts. Six genes known associated...
Several studies reported that severe acute respiratory syndrome coronavirus-2 antibody levels change over 6 months in participants receiving the vaccination. From enrolled 272 health care workers (HCWs), blood samples were obtained at 2, 16, and 24 weeks after second vaccination dose. In 267 noninfected HCWs, neutralizing antibodies decreased by 23.9%, anti-spike/receptor binding domain 53.8% weeks. We observed no significant difference reduction between sexes; however, younger individuals,...
The antibody titer of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed in 289 healthy healthcare workers who had completed second dose Pfizer-BioNTech disease 2019 (COVID-19) vaccine. Antibody tests were performed using both automated electrochemiluminescence immunoassay (ECLIA) and chromatographic lateral flow (LFIA). All subjects antibodies against receptor binding domain spike protein SARS-CoV-2 only one week after completing vaccination, became significantly...
There are sparse data concerning sex- and age-specific characteristics of community-acquired bacteraemia (CAB) hospital-acquired (HAB). Between January 2008 December 2012, we identified 2956 cases, which classified as CAB, HAB or healthcare-associated (HCAB). Almost half the pathogens were Escherichia coli in CAB patients. By contrast, Staphylococcus aureus was most frequent (16.2%) HCAB showed mixed features HAB. In E. significantly more abundant females than males (56.9 vs 24.3%,...
For correct interpretation of the high-density lipoprotein cholesterol (HDL-C) data from Korea National Health and Nutrition Examination Survey (KNHANES), values should be comparable to reference values. We aimed suggest a way calibrate KNHANES HDL-C 2008 2015 Centers for Disease Control Prevention (CDC) method values.We derived three calibration equations based on comparisons between laboratory CDC in 2009, 2012, using commutable frozen serum samples. The selection equation correcting each...
Despite strict guidelines for coronavirus disease 2019 (COVID-19), South Korea is facing its fourth pandemic wave. In this study, by using an automated electrochemiluminescence immunoassay assay, we tracked anti-spike protein receptor-binding domain (anti-S-RBD) antibody titer from the second dose to 2 weeks after booster vaccination. After dose, 234 participants had their anti-S-RBD titers decrease over time. We also showed (the third dose) increased average 14 (min-max, 2-255)-fold higher...
All Hb Hammersmith [β42(CD1)Phe→Ser, TTT>TCT] patients reported so far have been female, suggesting that this condition may occur as a negative, fatal intrauterine selection against males. In case report, we describe male of Hammersmith. A 6-month-old patient, born from ovum donation, presented with hemolytic anemia and cyanosis. Hemoglobin (Hb) electrophoresis revealed decreased (54.0%) A2 (0.3%) markedly increased F (45.7%) levels. Direct sequencing missense mutation in the HBB gene,...
Mi-Ae Jang, Sang-Yong Shin, Seungman Park, Moon-Woo Seong, Sung Sup and Sun- Hee Kim, as Diagnostic Genetics Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratory. J Lab Med Qual Assur 2014;36:71-83. https://doi.org/10.15263/jlmqa.2014.36.2.71
Mixed-species malaria infections are often unrecognized or underestimated.We hereby report the first described case of mixed infection with Plasmodium falciparum and ovale in a returned traveller Korea.In August 2016, 25-year-old from Cameroon Democratic Republic Congo presented fever.He was diagnosed as P. successfully treated artesunate.And 5 weeks after completion treatment, he fever infection.P. is rare cause shows delayed presentation due to its dormant liver stage hypnozoites.At...
Long QT syndrome (LQTS) is a genetically heterogeneous disorder associated with sequence variations in more than 10 genes; some cases, it caused by large deletions or duplications among the main, known LQTS-associated genes. Here, we describe 14-month-old Korean boy congenital hearing loss and prolonged interval whose condition was clinically diagnosed as Jervell Lange-Nielsen (JLNS), recessive form of LQTS. Genetic analyses using analysis multiplex ligation-dependent probe amplification...
Abstract Background Hepatitis B virus (HBV) infection remains a global concern with different epidemiologies due to several factors including migration, vaccination policies, and new antiviral treatment regimens. It is important understand the characteristics of patient population, prevalence diseases, assess test utilization evaluate clinical performance laboratory tests improve quality laboratories. Materials methods In this study, we evaluated serologic virologic hepatitis surface...
Hereditary hemolytic anemia comprises a group of disorders in which red blood cells are destroyed faster than they produced the bone marrow; various hereditary factors can cause this condition, including production defective Hb and erythrocyte membrane.Recently, we identified Koriyama, rare variant that was undetectable electrophoresis stability tests, patient with severe anemia.This is first study to show nucleotide-level sequence variations Koriyama.On basis our results, conclude unstable...
Jikyo Lee, M.D., Jung Hoon Choi, M.S., Eun-Hee Kim, Jihyun Im, B.S., Heeyoun Hwang, Ph.D., Seojin Yang, Joon Hee Kyunghoon Junghan Song, Seungman Park, and Sang Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0039
John Hoon Rim, M.D., Young-gon Kim, Sollip Rihwa Choi, Jee-Soo Lee, Seungman Park, Woochang Eun Young Song, Soo-Youn and Sail Chun, on behalf of the Pharmacogenetics Guideline Task-Force Team Korean Society Laboratory Medicine. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0572