A5054007340- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Health, Environment, Cognitive Aging
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Cardiac Health and Mental Health
- Renal cell carcinoma treatment
- GDF15 and Related Biomarkers
- CAR-T cell therapy research
- Cardiovascular Disease and Adiposity
- Statistical Methods in Clinical Trials
- Uterine Myomas and Treatments
- Health disparities and outcomes
- Colorectal and Anal Carcinomas
- Heme Oxygenase-1 and Carbon Monoxide
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
Roswell Park Comprehensive Cancer Center
2018-2025
NRG Oncology
2018-2025
Memorial Sloan Kettering Cancer Center
2018-2020
Cornell University
2018-2020
The University of Texas MD Anderson Cancer Center
2020
Women's Cancer Center of Nevada
2020
University of Cincinnati
2020
Sidney Kimmel Comprehensive Cancer Center
2020
Johns Hopkins University
2020
Samsung Medical Center
2020
PURPOSE We report the final, protocol-specified analysis of overall survival (OS) in GOG-0218, a phase III, randomized trial bevacizumab women with newly diagnosed ovarian, fallopian tube, or primary peritoneal carcinoma. METHODS A total 1,873 incompletely resected stage III to IV disease were randomly assigned 1:1:1 six 21-day cycles intravenous carboplatin (area under concentration v time curve 6) and paclitaxel (175 mg/m 2 ) versus chemotherapy plus concurrent (15 mg/kg, maintenance...
Background— Heart failure (HF) is a prevalent and deadly disease, preventive strategies focused on at-risk individuals are needed. Current HF prediction models have not examined subtypes. We sought to develop validate risk for with preserved reduced ejection fraction (HFpEF, HFrEF). Methods Results— Of 28,820 participants from 4 community-based cohorts, 982 developed incident HFpEF 909 HFrEF during median follow-up of 12 years. Three cohorts were combined, 2:1 random split was used...
Secondary surgical cytoreduction in women with platinum-sensitive, recurrent epithelial ovarian, primary peritoneal, or fallopian-tube ("ovarian") cancer is widely practiced but has not been evaluated phase 3 investigation.
Background— The American Heart Association Cardiovascular Health score (CVH score) is inversely associated with cardiovascular disease (CVD) incidence, but the mechanisms underlying this association warrant exploration. Methods and Results— We related CVH to circulating biomarkers prevalent subclinical CVD (defined as ≥1 of following: increased carotid intima-media thickness or stenosis, left ventricular hypertrophy [by ECG echocardiography], systolic dysfunction, microalbuminuria, a reduced...
<h3>Importance</h3> Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced (HFrEF), yet associations biomarkers future subtype are incompletely understood. <h3>Objective</h3> To evaluate the 12 cardiovascular incident HFpEF vs HFrEF among adults from general population. <h3>Design, Setting, and Participants</h3> This study included 4 longitudinal community-based cohorts: Cardiovascular Health Study (1989-1990; 1992-1993 for supplemental...
The American Heart Association developed the ideal cardiovascular health (CVH) index as a simple tool to promote CVH; yet, its association with brain atrophy and dementia remains unexamined.Our aim was investigate prospective of CVH vascular injury, including 10-year risks incident stroke dementia, well cognitive decline on magnetic resonance imaging, measured for ≈7 years. We studied 2750 stroke- dementia-free Framingham Study Offspring cohort participants (mean age, 62±9 years; 45% men)....
Background Data on the temporal trends in ideal cardiovascular health ( CVH ) as well their association with subclinical/overt disease CVD and death are limited. Methods Results This study included 3460 participants attending ≥1 of 4 consecutive exams Framingham Heart Study (1991–2008, mean age 55.4 years, score ranged 0–14). We created groups describing changes between examination cycles 5 8, using first last attended (high‐high: starting ≥8, referent; high‐low: ≥8 start ≤7 last; low‐high:...
Despite standard chemoradiotherapy (CRT), most women with lymph node (LN)-positive cervical cancer experience disease recurrence. Immunotherapy is being investigated in the up-front treatment setting.To assess safety of sequential immunotherapy after CRT and to investigate human papillomavirus (HPV) genotype HLA allele status on survival programmed cell death 1 (PD-1) expression before immunotherapy.This prospective phase trial conducted 29 Gynecology Oncology Cooperative Group member...
Background: The remaining lifetime risk (RLR) is the probability of developing an outcome over remainder one’s lifespan at any given age. RLR for atherosclerotic cardiovascular disease (ASCVD) in three 20-year periods were assessed using data from a single community-based cohort study predominantly White participants. Methods: Longitudinal Framingham 3 epochs (epoch 1, 1960–1979; epoch 2, 1980–1999; 3, 2000–2018) evaluated. first ASCVD event (myocardial infarction, coronary heart death, or...
Abstract Interpreting cancer clinical trial results often depends on addressing issues of multiplicity. When testing multiple hypotheses, unreliable findings can occur by chance due to the inflation type I error rate, probability mistakenly rejecting null hypothesis when is true. In this setting, researchers may set rate (or alpha level) low limit false positive and interpretation a causal relationship where none exists. Conversely, overly conservative control result in declaring findings,...
Purpose We conducted a randomized phase III trial to determine whether adjuvant chemotherapy improves survival in women with uterine leiomyosarcoma. Methods Women uterus-confined, high-grade leiomyosarcoma who were confirmed disease free by imaging randomly assigned four cycles of gemcitabine plus docetaxel, followed doxorubicin, or observation. All for evidence recurrence. The primary end point was overall (OS). Results With international collaboration, 38 the targeted accrual 216 patients...
Abstract Purpose: A phase I clinical trial (GOG-9929) examined the safety and efficacy of adjuvant immune-modulation therapy with checkpoint inhibitor ipilimumab [anti–CTL antigen-4 (anti–CTLA-4)] following chemoradiation (CRT) for newly diagnosed node-positive human papillomavirus (HPV)-related cervical cancer. To better understand mechanism action to identify predictive biomarkers, immunologic viral correlates were assessed before, during, after treatment. Patients Methods: Twenty-one...
PURPOSE Pelvic recurrence is a frequent pattern of relapse for women with endometrial cancer. A randomized trial compared progression-free survival (PFS) after treatment radiation therapy alone as concurrent chemotherapy. MATERIALS AND METHODS Between February 2008 and August 2020, 165 patients were randomly assigned 1:1 to receive either or combination chemotherapy treatment. The primary objective this study was determine whether chemoradiation more effective than at improving PFS. RESULTS...
Fetuin-A, retinol-binding protein 4 (RBP4), and fatty-acid binding (FABP4) are novel biomarkers that may link adiposity to insulin resistance the metabolic syndrome (MetSyn). The aim of this study was investigate correlates these three in a large community-based sample. Serum concentrations fetuin-A, RBP4, FABP4 were assayed 3658 participants Third Generation Framingham Heart Study cohort (mean age 40 yr, 54% women). We used multivariable regression cross-sectionally relate resistance,...
Background Left ventricular diastolic dysfunction ( DD ) is common, particularly in women and older individuals, it associated with adverse cardiovascular outcomes. We evaluated the impact of age‐ sex‐specific diagnostic criteria on assessment community‐based Framingham Heart Study. Methods Results estimated reference limits for echocardiographic measures a healthy subsample (N=2355, mean age 44 years, 66% women). The prevalence, correlates, association future disease were compared using...
5501 Background: GOG-0213 is an international, open-label, randomized phase 3 trial in women with PSOC two objectives: 1) to study the addition of B paclitaxel/carboplatin concurrently and as maintenance; 2) evaluate impact SSC. The primary endpoint overall survival (OS). We previously reported results Objective 1 [HR 0.829; 95% CI: 0.683-1.005; p = 0.056) Coleman RL, et al Lancet Oncol 2017], now report outcomes 2. Methods: From Dec-2007 until Jun-2017, 485 investigator-determined...
The American Heart Association Cardiovascular Health (CVH) score is inversely associated with cardiovascular disease, but its relations to cardiac remodeling traits and heart failure (HF) incidence have not been examined.A 14-point was constructed for each participant based on the presence of poor, intermediate, or ideal status 7 CVH metrics (ideal score=14). We related echocardiographic cross-sectionally HF prospectively in Framingham Offspring Study. In age- sex-adjusted models, a higher...
Concerns have been raised that the 2013 atherosclerotic cardiovascular disease (ASCVD) risk estimator overpredicts in contemporary cohorts. Whether suboptimal calibration will lead to overtreatment with statins is unknown. We investigated numbers of people eligible for statin treatment Framingham Heart Study Offspring Cohort, based on cholesterol guidelines, and estimated proportion may be overtreated as a result potential miscalibration ASCVD estimator.During median follow-up 10 years, we...
Background Hypertensive individuals on blood pressure ( BP )–lowering treatment with in the normal or high‐normal range have higher cardiovascular risk than untreated persons usual same range. This residual (relative and absolute) is not well quantified may be attributable part to burden of subclinical disease treated individuals. Methods Results We assigned 3024 Framingham Offspring Cohort participants 5 categories based systolic SBP ) diastolic DBP use ‐lowering treatment: (1) / <120/80...