A5032896437- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Electrochemical Analysis and Applications
- Bone Tissue Engineering Materials
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Cancer therapeutics and mechanisms
- Mercury impact and mitigation studies
- Retinoids in leukemia and cellular processes
- Heavy Metal Exposure and Toxicity
- Analytical Chemistry and Sensors
- Sulfur Compounds in Biology
- Drug Transport and Resistance Mechanisms
- Heavy Metals in Plants
- Carbon and Quantum Dots Applications
- Fungal Plant Pathogen Control
- Phytochemical and Pharmacological Studies
- Cancer, Hypoxia, and Metabolism
- Nonlinear Optical Materials Studies
- Synthesis and biological activity
- Nanofabrication and Lithography Techniques
- Plant Gene Expression Analysis
Lanzhou University
2012-2023
Gansu University of Traditional Chinese Medicine
2005-2022
Lanzhou City University
2014-2017
State Key Laboratory of Applied Organic Chemistry
2014
A novel selective fluorescent chemosensor based on an 8-hydroxyquinoline-appended fluorescein derivative (L1) was synthesized and characterized. Once combined with Cu2+, it displayed high specificity for sulfide anion. Among the various anions, only anion induced revival of fluoresecence L1, which quenched by resulting in “off–on”-type sensing What’s more, sensor retrievable to indicate anions S2–, turn, increased. With addition compound L1 could give rise a visible pink-to-yellow color...
In bone tissue engineering, it is imperative to design multifunctional biomaterials that can induce and assemble bonelike apatite close natural bone. this study, graphene oxide (GO) was functionalized by carrageenan. The resulting GO-carrageenan (GO-Car) composite further used as a substrate for biomimetic cell-mediated mineralization of hydroxyapatite (HA). It confirmed carrageenan on the GO surface facilitated nucleation HA. observation effect GO-Car adhesion, morphology, proliferation...
We report the development of a fluorescein-based chemosensor (L1) for monitoring ions or micromolecules (H2S). Copper are known to be toxic at high concentrations and hydrogen sulfide induces various problems. Herein we develop simple method detecting Cu(II) H2S with selectivity sensitivity. The L1 displays on–off–on type fluorescence change alternately added media along reversible forming–separating complex. potential biomedical relevance chemical mechanisms involved in detection is described.
We report a facile modification of graphene oxide (GO) by gelatin to mimic charged proteins present in the extracellular matrix during bone formation. The bioinspired surface GO–gelatin (GO–Gel) composite was used for biomimetic mineralization hydroxyapatite (HA). A detailed structural and morphological characterization mineralized performed. Additionally, MC3T3-E1 cells were cultured on GO–Gel surfaces observe various cellular activities HA mineralization. Higher such as cell adhesion,...
A highly sensitive and selective fluorescent probe for inorganic organic mercury species displays colorimetric ratiometric response in a buffer solution via promoted cleavage reaction. The is demonstrated to detect CH3HgCl living cells.
A Fe3+ chemosensor L1 was successfully synthesized with a quinoline moiety bound to rhodamine 6G hydrazide. The sensor shows high selectivity and sensitivity in aqueous solution the presence of other trace metal ions organisms, abundant cellular cations prevalent toxic environment. In addition, biological imaging micro computed tomography (MCT) technology studies have demonstrated that could act as turn-on fluorescent for living cells.
Small organic dyes with large two-photon absorption (TPA) cross sections (δ) are more desirable in many applications compared molecules. Herein, we proposed a facile theoretical method for the fast screening of small molecules as potential TPA dyes. This is based on analysis to natural transition orbitals (NTOs) directly associated transition. Experimental results indolic squaraine (ISD) confirmed that their strongly correlated delocalization degree NTOs S2 excited states. Aided by this...
A new oxidative C–O bond cleavage reaction-based probe FluHMPP was designed and prepared. displays excellent selective turn-on fluorescence response for CuII in aqueous solution under visible light excitation. The products are fully characterized. Fluorescein fragment is further oxidized to highly fluorescent MFME (3′-O-methylfluorescein methyl ester), benzyl ether of imine has been transformed carboxyl. Confocal microscopy experiments have demonstrated that could also be used live cells the...
A new fluorescent sensor L1 based on coumarin was synthesized. It shows high sensitivity and selectivity toward Cu2+ in aqueous solution. The complexation mode corresponding quenching mechanism were elucidated by ESI-MS DFT calculations. In addition, biological imaging studies have demonstrated that can detect living cells.
Various fluorescent nanoparticles have been applied in imaging of tissues or intracellular structures. Searching for biocompatible that can be observed under visible light is fundamental importance the applications living cells. In this study, a simple, template-based route synthesis hydroxyapatite (HA) has developed. Well-dispersed HA prepared by using SiO2 as templates (THA) were surface-functionalized with fluorescein isothiocyanate (FITC), resulting bright and stable particles...
The aim of this research was to investigate the antioxidant and anti-apoptotic activities <italic>Potentilla anserina</italic> polysaccharide (PAP) on kidney damage induced by cadmium (Cd) <italic>in vitro</italic> vivo</italic>.
In this research, we developed a "clean" and "wet" route to produce sandwich-like fluorescent CdQ2/GO composites sheets starting from graphene oxide (GO) Cd2+ in water/ethanol solution one pot. The as-prepared were fully characterized by IR, XRD, TEM TGA analysis. exhibited strong fluorescence emission centered at 500 nm. Both the solid sample water dispersion could demonstrate green fluorescence. When incubated with Hep G2 cells 37 °C, found adhere surroundings of cell membrane, resulting...
We report a biomimetic mineralization of hydroxyapatite induced by poly-dopamine-functionalized reduced graphene oxide (RGO-PDA). Graphene was first simultaneously and surface functionalized one-step oxidative polymerization dopamine. The resultant RGO-PDA further used as bioinspired to mimic the during bone formation. MC3T3-E1 cells were cultured on substrates observe various cellular activities mineralization. show higher such proliferation, adhesion, osteogenic differentiation over bare...
A new 1,3,4-oxadiazole-based fluorescence chemosensor 1, N-(2-ethoxy-2-oxoethyl)-N-(5-(2-hydroxy-3,5-di-tert-butylphenyl)-[1,3,4]oxadiazol-2-yl)glycine ethyl ester, has been designed and synthesized. Its properties selectivity for various metal ions were investigated in detail. prominent enhancement only Zn(2+) was found aqueous acetonitrile solution the response mechanism of 1 analyzed by time-resolved decay DFT calculations. Furthermore, imaging living cells successfully applied.
A colorimetric and ratiometric fluorescent chemodosimeter for Hg2+ has been developed based on mercury ion-promoted hydrolysis of a naphthalimide-derived aryl vinyl ether. The displays highly sensitive selective response with significant changes in both color (from colorless to jade-yellow) fluorescence blue green) PBS buffer solution (containing 1% CH3CN, pH = 7.4). exhibits towards very low detection limit (3.6 nM), which can be used detect ions drinking water. Furthermore, the...