A5038036905- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Infectious Diseases and Mycology
- Respiratory and Cough-Related Research
- Sarcoidosis and Beryllium Toxicity Research
- Drug-Induced Adverse Reactions
- Systemic Sclerosis and Related Diseases
- Pleural and Pulmonary Diseases
- Blood disorders and treatments
- Animal Virus Infections Studies
- Actinomycetales infections and treatment
- Inflammatory Myopathies and Dermatomyositis
- Estrogen and related hormone effects
- Polyomavirus and related diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Disease Case Reports and Treatments
- Immune Response and Inflammation
- Testicular diseases and treatments
- IL-33, ST2, and ILC Pathways
- Cardiac tumors and thrombi
- Lung Cancer Treatments and Mutations
- Respiratory viral infections research
- Infrared Thermography in Medicine
- Vasculitis and related conditions
- Multiple and Secondary Primary Cancers
Jichi Medical University
2004-2021
Saiseikai Utsunomiya hospital
2021
Jichi Medical University Hospital
2004-2010
Osaka City University
2009-2010
Pulmonary Associates
2007-2009
Gunma University
2000-2002
The University of Tokyo
2002
Biopsy by video-assisted thoracoscopic surgery (VATS) for interstitial pneumonia allows collection of samples sufficient accurate histologic diagnosis. Although VATS is relatively safe, several reports have suggested that surgical lung biopsy may be a risk factor acute exacerbation idiopathic pulmonary fibrosis (IPF). We retrospectively reviewed data on the 113 cases underwent to diagnose diffuse parenchymal disease in our department between 1994 and 2006, analyzed its complications,...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Background and objective: IPF is an independent risk factor for lung cancer, but the mechanism of this association has not fully been elucidated. The role Torque teno virus (TTV) in respiratory disease poorly understood, although it shown that infection with TTV associated activity prognosis IPF. This study aimed to investigate prevalence titre DNA among patients cancer. Methods: presence was determined by PCR sera both cancer ( n = 22), only 35), 142). Results: detectable all 94.3% 97.2%...
NEDD8 ultimate buster 1 (NUB1) is an interferon (IFN)-inducible protein that downregulates expression and its conjugation system. Although overexpression of NUB1 induces a growth-inhibitory effect in cells, the mechanisms underlying anti-mitogenic actions cancer cells remain uncertain. We investigated anti-cancer effects human renal cell carcinoma (RCC) cells. Nine RCC were used for this study. The proliferation exposed to IFN-α was measured by water-soluble tetrazolium salt assay. level...
Reactive oxygen species play an important role in the pathogenesis of acute lung injury and pulmonary fibrosis. The present authors hypothesise that edaravone, a free-radical scavenger, is able to attenuate bleomycin (BLM)-induced mice by decreasing oxidative stress. Lung was induced female ICR intratracheal instillation 5 mg x kg(-1) BLM. Edaravone (300 kg(-1)) administered intraperitoneal administration 1 h before BLM challenge. significantly improved survival rate treated with from 25...
Background Inhalation of N-acetylcysteine (NAC) has been carried out in our department since 1994 for treating interstitial pneumonia such as idiopathic pulmonary fibrosis (IPF). In this study, the clinical efficacy and safety long-term NAC inhalation monotherapy IPF was investigated. Methods 23 34 cases diagnosed by surgical lung biopsy between 2008. The treatment continued one year or longer 14 cases. these 11 without treatment, courses, prognosis, function (%FVC, %DLco, %TLC), changes...
A 26-year-old man presented at our hospital in 2008 to undergo detailed investigations as part of a routine health examination. Chest computed tomography (CT) showed linear and reticular opacities with, part, diffuse calcification the lung fields bilaterally. surgical biopsy was performed histological findings were compatible with diagnosis pulmonary ossification (DPO) dendriform type. DPO usually occurs secondary disease. As changes interstitial fibrosis minimal rather than not significant...
Objective Acute respiratory worsening is defined as the unexpected rapid deterioration of idiopathic pulmonary fibrosis (IPF), and acute known an exacerbation IPF. Torque teno virus (TTV) a circular single-stranded DNA whose pathological significance remains unclear. The aim present study was to investigate prevalence titer TTV in IPF patients with worsening. Methods serum measured using real-time PCR nine (two treated steroids immunosuppressants; seven without or immunosuppressants) who...
Diabetes mellitus reduces immunological activity and increases susceptibility to various infections. Hochuekkito (TJ-41) has been reported improve the weakened physical condition of chronic diseases. BALB/c mice were divided into three groups; groups A B fed a standard diet, group C, TJ-41 diet. Two weeks after starting these diets, hyperglycemia was induced in C by injection with streptozotocin. later, bronchoalveolar lavage performed. Toll-like receptor (TLR) ligands (TLR2: peptidoglycan,...
Renal angiomyolipomas (R-AMLs) are major complications of lymphangioleiomyomatosis (LAM). The objective this study was to better understand the influence R-AMLs in patients with LAM on prognosis and other clinical factors related respiration, investigate management LAM.We retrospectively investigated features 7 [4 were TSC (Tuberous sclerosis complex)-LAM 3 S (sporadic)-LAM] complicated by admitted our hospital from 1997 2008.All females mean age at diagnosis 40.7 years (31.7 for TSC-LAM...
Invasive pulmonary aspergillosis (IPA) is an acute infection of Aspergillus species to the lungs. It generally occurs in immunocompromised hosts, especially with neutropenia. We report a 30-year-old puerperant, who developed IPA from agranulocytosis. She had been treated for threatened labor ritodrine and cefepime, one which induced After vaginal delivery twins, pneumonia emerged right lower lobe. was diagnosed have according halo sign on computed tomography (CT) positive circulating...
Abstract: Indomethacin is one of the most popular non‐steroidal anti‐inflammatory drugs (NSAID). Although NSAID occasionally provoke bronchospasm and hypersensitivity pneumonia, they seldom cause lymphadenopathy. This first report in which induced both eosinophilic pneumonia bulky intrathoracic lymphadenopathy simultaneously. A 76‐year‐old Japanese man experienced high fever dyspnoea after using an indomethacin suppository. Computed tomography scan his chest revealed massive mediastinal...
Nocardiosis is a subacute or chronic suppurative infection caused by Nocardia species. Although it more common in immunocompromised hosts, idiopathic pulmonary fibrosis (IPF) has not been recognized as predisposing factor for nocardial infection. We report case of IPF, which nocardiosis developed during treatment with prednisolone and cyclophosphamide. The risk may be increased cases IPF on immunosuppressive therapy. Since often accompanies lung carcinoma, important to correctly...
Indomethacin is one of the most popular non-steroidal anti-inflammatory drugs (NSAID). Although NSAID occasionally provoke bronchospasm and hypersensitivity pneumonia, they seldom cause lymphadenopathy. This first report in which induced both eosinophilic pneumonia bulky intrathoracic lymphadenopathy simultaneously. A 76-year-old Japanese man experienced high fever dyspnoea after using an indomethacin suppository. Computed tomography scan his chest revealed massive mediastinal hilar along...
症例は51 歳女性.2008 年12 月に右大腿から膝にかけて丘疹が出現し,左上腕・臀部・両側大腿に皮下硬結を自覚した.その約2週間後から37 –38 ℃の発熱を認め,両膝・足関節の腫脹,疼痛を自覚し,さらに左膝から下腿にかけて結節性紅斑が出現した.臀部皮下硬結の生検で非乾酪性類上皮細胞肉芽腫を認めた.胸部単純X線写真で肺門部リンパ節腫脹を認めたため,サルコイドーシスが疑われ当科に紹介された.MRI画像所見から腫瘤型筋サルコイドーシスと診断した.また両側肺門リンパ節腫脹を認め,関節炎,結節性紅斑を伴っていたことからLöfgren 症候群を合併していたと考えられた.Löfgren 症候群は本邦では稀であり,また腫瘤型筋サルコイドーシスとの合併は報告されておらず,貴重な症例と考え報告する.