Adam M Lee
A5020575990- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Prostate Cancer Treatment and Research
- Long-Term Effects of COVID-19
- Electronic Health Records Systems
- RNA Research and Splicing
- Biomedical Text Mining and Ontologies
- Genetic factors in colorectal cancer
- Sexual Differentiation and Disorders
- Data-Driven Disease Surveillance
- Cancer-related Molecular Pathways
- COVID-19 Digital Contact Tracing
- Nutrition, Genetics, and Disease
- Frailty in Older Adults
- COVID-19 epidemiological studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Palliative Care and End-of-Life Issues
- COVID-19 Impact on Reproduction
- Inflammasome and immune disorders
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Artificial Intelligence in Healthcare and Education
- Colorectal Cancer Screening and Detection
University of Minnesota
2016-2024
Johns Hopkins University
2023
University of North Carolina at Chapel Hill
2020-2022
Mayo Clinic in Arizona
2020
Mayo Clinic
2015
American Society of Clinical Oncology
2015
PharmacoGenetics (China)
2015
University of California, San Francisco
2015
Coronavirus disease 2019 (COVID-19) poses societal challenges that require expeditious data and knowledge sharing. Though organizational clinical are abundant, these largely inaccessible to outside researchers. Statistical, machine learning, causal analyses most successful with large-scale beyond what is available in any given organization. Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level from many centers.The...
Sex differences have been widely observed in human health. However, little is known about the underlying mechanism behind these sex differences. We hypothesize that sex-differentiated genetic effects are contributors of phenotypic Focusing on a collection drug metabolism enzymes and transporters (DMET) genes, we discover regulatory mechanisms between genes complex traits. Here, show were present at genome-level DMET gene regions for many These reflected levels expression endogenous serum...
Optimizing antipsychotic pharmacotherapy is often challenging due to significant variability in effectiveness and tolerability. Genetic factors influencing pharmacokinetics pharmacodynamics may contribute some of this variability. Research studies have characterized these pharmacogenetic relationships, genetic markers are now available as clinical tests. These advances pharmacogenetics research test availability great potential improve outcomes quality life psychiatric patients. For...
Abstract Objectives To define pregnancy episodes and estimate gestational age within electronic health record (EHR) data from the National COVID Cohort Collaborative (N3C). Materials Methods We developed a comprehensive approach, named Hierarchy rule-based episode Inference integrated with Pregnancy Progression Signatures (HIPPS), applied it to EHR in N3C (January 1, 2018–April 7, 2022). HIPPS combines: (1) an extension of previously published algorithm, (2) novel algorithm detect...
Significance Identification of genomic biomarkers that predict response to anticancer agents is the central research problem cancer precision medicine. While vast majority human genome encodes long noncoding RNAs (lncRNAs) as compared protein-coding genes, thus far characterization lncRNAs potential has proved challenging. Here, we leverage data from large-scale cell line screens model hundreds drugs a function lncRNA expression or somatic alteration. By carefully accounting for confounding...
Abstract People with HIV may be at increased risk for long COVID after acute SARS-CoV-2 infection. We investigated the association between and in two large electronic health record databases. Using data from Patient-Centered Clinical Research Network (PCORnet) National Cohort Collaborative (N3C) 1/1/2018 to 4/30/2024, our analytic sample included individuals aged ≥21 years SARS-CoV-2. All were classified as having or not. estimated adjusted odds ratio (aOR) of by status using logistic...
Severe (grade≥3) adverse events (AEs) to 5-fluorouracil (5-FU)-based chemotherapy regimens can result in treatment delays or cessation, and, extreme cases, life-threatening complications. Current genetic biomarkers for 5-FU toxicity prediction, however, account only a small proportion of toxic cases. In the current study, we assessed DPYD variants suggested correlate with toxicity, deep intronic variant (c.1129-5923 C>G), and four within haplotype (hapB3) 1953 stage III colon cancer patients...
Abstract Objective This study sought to evaluate whether synthetic data derived from a national coronavirus disease 2019 (COVID-19) dataset could be used for geospatial and temporal epidemic analyses. Materials Methods Using an original (n = 1 854 968 severe acute respiratory syndrome 2 tests) its derivative, we compared key indicators of COVID-19 community spread through analysis aggregate zip code-level curves, patient characteristics outcomes, distribution tests by code, indicator counts...
Many research studies fail to enroll enough participants. Patient-facing electronic health record applications, known as patient portals, may be used send invitations eligible patients.The first aim was determine if receipt of a portal recruitment invitation associated with enrollment in large ongoing study newborns (Early Check). The second there were differences opening the and by race ethnicity, age, or rural/urban home address.We computable phenotype queried care system's clinical data...
Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Chronic lung (CLD) has been identified in small-scale studies a potential risk factor for COVID. This large-scale retrospective cohort study using the National COVID Cohort Collaborative data evaluated link between CLD and over 6 months SARS-CoV-2 We included adults (aged ≥18 years) who...
While functional studies of long noncoding RNAs (lncRNAs) have mostly focused on how they influence disease diagnosis and prognosis, the pharmacogenomic relevance lncRNAs remains largely unknown. Here, we test hypothesis that expression a lncRNA, grow arrest-specific 5 ( GAS5 ) can be biomarker for docetaxel response in castration resistant prostate cancer (CRPC) using both (PCa) cell lines CRPC patient datasets. Our results suggest lower is associated with resistance PCa patients. Further...
Abstract Background Anticoagulation (AC) utilization patterns and their predictors among hospitalized coronavirus disease 2019 (COVID-19) patients have not been well described. Methods Using the National COVID Cohort Collaborative, we conducted a retrospective cohort study (2020–2022) to assess AC use identify factors associated with therapeutic employing modified Poisson regression. Results Among 162 842 COVID-19 patients, 64% received 24% AC. Therapeutic declined from 32% in 2020 12% 2022,...
The COVID-19 pandemic has changed the delivery of surgical care.Early in pandemic, an association between SARS-CoV-2 infection and adverse postoperative outcomes prompted implementation risk mitigation strategies, including routine asymptomatic testing postponement procedures 1-3 .In May 2023, WHO declared end to global public health emergency; however, disease's implications with regard perioperative care persist.As novel variants emerge, understanding influence reinfection on is important...
Background/Objectives: Triple-negative breast cancer (TNBC) is an aggressive form of with limited treatment options. The nuclear export protein XPO1 has emerged as a potential therapeutic target in cancer, but its role TNBC not been fully characterized. This study investigates the repurposing selinexor, FDA-approved inhibitor, novel options for TNBC. Methods: A computational drug pipeline was used to predict patient tumor responses hundreds drugs. We identified inhibitors candidate and...
508 Background: Severe adverse events (AEs) to 5-fluorouracil (5-FU) constitute a major dilemma in CC treatment. We recently demonstrated that specific deleterious DPYD variants the coding region were highly predictive of grade >3 (G3+) AEs stage III pts receiving adjuvant 5-FU based combination chemotherapy [Lee et al. JNCI. In press]. Other studies have suggested potential associations between and non-coding variants: novel haplotype (HapB3) containing three intronic (c.483+18 G>A,...
209 Background: Predictive markers of response to AA are not known. In a prior study, we found that 8 single nucleotide polymorphisms (SNPs) from 4 candidate hormone-related genes (JAK2, TRMT11, NKX3-1 and HSD17B12) were associated with in HSPC North American cohort 519 subjects. We attempt replicate these findings Portuguese patients. Methods: The consisted 308 patients, the primary endpoint was time failure, defined as initiating continuous two serial PSA increases over nadir, initiation...
e16117 Association of germline variation with androgen ablation (AA) failure in advanced hormone-sensitive prostate cancer (HSPC) Background: Predictive markers response to AA are not known. In a prior study, we found that 8 single nucleotide polymorphisms (SNPs) from 4 candidate hormone-related genes (JAK2, TRMT11, NKX3-1 and HSD17B12) were associated HSPC North American cohort 519 subjects. We attempt replicate these findings Portuguese patients. Methods: The consisted 308 patients, the...
e22515 Background: Osteosarcoma is a skeletal malignancy affecting children, adolescents, and young adults. Surgical resection chemotherapy are the mainstay of therapy with three-drug regimen - cisplatin, doxorubicin, methotrexate. However, prognosis remains poor mainly due to chemo-resistance and/or metastases. Emerging evidence has shown that long non-coding RNAs (lncRNAs) implicated in drug sensitivity cancer metastasis. Our lab recently identified strong significant association between...
<sec> <title>BACKGROUND</title> Many research studies fail to enroll enough participants. Patient-facing electronic health record applications, known as patient portals, may be used send invitations eligible patients. </sec> <title>OBJECTIVE</title> The first aim was determine if receipt of a portal recruitment invitation associated with enrollment in large ongoing study newborns (Early Check). second there were differences opening the and by race ethnicity, age, or rural/urban home address....