A5061519603- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Diet and metabolism studies
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Amino Acid Enzymes and Metabolism
- Adipose Tissue and Metabolism
- Electromagnetic Fields and Biological Effects
- Spaceflight effects on biology
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism and Genetic Disorders
- Light effects on plants
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Dietary Effects on Health
- Psychological and Temporal Perspectives Research
- Animal Behavior and Reproduction
- Biochemical effects in animals
- Infant Nutrition and Health
- Neurotransmitter Receptor Influence on Behavior
Kyushu University
2015-2025
New York University Press
2017
Cambridge University Press
2017
Goethe University Frankfurt
2007-2013
Nagoya University
2001-2009
Institute of Animal Physiology of the Slovak Academy of Sciences
2009
Local thyroid hormone catabolism within the mediobasal hypothalamus (MBH) by hormone-activating (DIO2) and -inactivating (DIO3) enzymes regulates seasonal reproduction in birds mammals. Recent functional genomics analysis has shown that long days induce thyroid-stimulating production pars tuberalis (PT) of pituitary gland, which triggers DIO2 expression ependymal cells (EC) MBH. In mammals, nocturnal melatonin secretion provides an endocrine signal photoperiod to PT contains receptors high...
Abstract Recently, it has been found that the gut microbiota influences functions of host brain by affecting monoamine metabolism. The present study focused on relationship between and amino acids. Specific pathogen-free (SPF) germ-free (GF) mice were used as experimental models. Plasma regions sampled from at 7 16 weeks age, analysed for free d - l -amino acids, which are believed to affect many physiological functions. At plasma concentrations -aspartic acid ( -Asp), -alanine -Ala),...
Objectives: This study investigated the long-term effects of maternal undernutrition on overall muscle metabolism, growth performance, and characteristics in postnatal offspring Wagyu (Japanese Black) cattle. Methods: cows were divided into nutrient-adequate (control, CNT; n = 4, 120% requirements) nutrient-restricted groups (NR; 4; 60% requirements), treated from day 35 gestation until parturition. Diets delivered basis crude protein requirements, meeting 100% 80% dry matter requirements...
The molecular mechanisms underlying photoperiodic time measurement are not well understood in any organism. Relatively recently, however, it has become clear that thyroid hormones play an important role photoperiodism, and a previous study we reported long daylengths Japanese quail increase hypothalamic levels of T(3) the hormone-activating enzyme, type 2 iodothyronine deiodinase. present extends these observations to measure gene hormone-inactivating 3 Levels decreased after exposure days,...
In birds, the mediobasal hypothalamus (MBH) including infundibular nucleus, inferior hypothalamic and median eminence is considered to be an important center that controls photoperiodic time measurement. Here we show expression patterns of circadian clock genes in MBH, putative suprachiasmatic nucleus (SCN), pineal gland, which constitute pacemaker under various light schedules. Although were different between long short photoperiod SCN results not consistent with those night interruption...
The molecular mechanisms responsible for seasonal time measurement have yet to be fully described. Recently, we used differential analysis identify that the type 2 iodothyronine deiodinase (Dio2) gene is photoperiodic response of gonads in Japanese quail. It was found expression Dio2 mediobasal hypothalamus induced by light and T(3) content increased under long day conditions. In addition, showed intracerebroventricular infusion mimics photoperiodically testicular growth. Because it well...
It is now known that circadian clocks are localized not only in the central pacemaker but also peripheral organs. An example of a clock-dependent organ ovary domestic poultry which ovulation induced by positive feedback action ovarian progesterone on neuroendocrine system to generate preovulatory release LH during daily 6-10 h "open period" ovulatory cycle. has been assumed previously timing controlled solely mechanism within system. Here, we question this assumption demonstrating expression...
Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals additional binding sites suggested, but the receptor mediates effects of on gonadal response has not yet identified. We therefore investigated mice whether how targeted disruption MT1, MT2, or both types affects expression level two key genes for regulation, type 2 3 deiodinase ( Dio2 Dio3 , respectively). These are expressed ependymal cell layer lining...
Photorefractoriness is the insensitivity of gonadal development to stimulatory effects long photoperiods in birds and inhibitory short small mammals. Its molecular mechanism remains unknown. Recently, it has been shown that reciprocal expression thyroid hormone-activating enzyme [type 2 deiodinase (Dio2)] -inactivating 3 (Dio3)] genes mediobasal hypothalamus critical for photoperiodically induced growth. Since hormones are required not only photoinduction, but also induction...
In most animals that live in temperate regions, reproduction is under photoperiodic control. long-day breeders such as Japanese quail and Djungarian hamsters, type 2 deiodinase (Dio2) plays an important role the mediobasal hypothalamus, catalyzing conversion of prohormone T4 to bioactive T3 regulate response gonads. However, molecular basis for seasonal short-day remains unclear. Because thyroid hormones are also known be involved breeders, we examined effect artificial stimulus on Dio2...
In many species living in temperate zones, reproduction is controlled by the photoperiod. Recent findings have clarified that type 2 iodothyronine deiodinase (Dio2) plays a significant role photoperiodic response of gonads mediobasal hypothalamus, converting prohormone T(4) into bioactive T(3). mammals, Dio2 expression suppressed long-term melatonin injections, although signal transduction pathways link to are unknown. As first step approach problem, we here investigated temporal dynamics...
The disruption of the circadian clock by frequent shifts in light–dark cycle, such as shift-work or jet lag, increases risk many diseases, including cancer. Experimental also tumor development mice, although most studies used strains that are genetically impaired melatonin synthesis and secretion. Here, we examined effects experimental chronic lag with 8 h advances cycle every 2 days for 10 on central peripheral clocks CBA/N strain normal profiles Mice were exposed to constant darkness after...
Circadian rhythms are generated by an internal biological clock. The suprachiasmatic nucleus (SCN) in the hypothalamus is known to be dominant clock regulating circadian mammals. In birds, two nuclei, so-called medial SCN (mSCN) and visual (vSCN), have both been proposed avian SCN. However, it remains unsettled question which nuclei homologous mammalian We identified genes Japanese quail demonstrated that these expressed oscillators, pineal retina. Here, we report mSCN but not vSCN quail,...
Abstract Photoperiodic regulation of reproduction in birds and mammals involves thyrotropin β-chain (TSHb), which is secreted from the pars tuberalis (PT) controls expression deiodinase type 2 3 ependymal cell layer infundibular recess (EC) via TSH receptors (TSHRs). To analyze impact melatonin molecular clockwork on Tshb Tshr, we investigated melatonin-proficient C3H wild-type (WT), receptor 1-deficient (MT1-/-) or clockprotein PERIOD1-deficient (mPER1-/-) mice. Expression TSHb...
Recently, we have shown that C57BL/6J mice exhibit depression-like behavior under short photoperiod and suggested them as an animal model for investigating seasonal affective disorder (SAD). In this study, tested if manipulations of the circadian clock with melatonin treatment could effectively modify anxiety-like behaviors brain serotonergic system in mice. Under photoperiods (8-h light/16-h dark), daily treatments 2 h before light offset significantly altered 24-h patterns mRNA expression...
The photoperiodic response of the gonads requires T3, which is generated photoperiodically from T4 by type 2 iodothyronine deiodinase in hypothalamus. Although thyroid hormones were long thought to traverse plasma membrane passive diffusion due their lipophilic nature, it now known that several organic anion transporting polypeptides (Oatp) transport into target cells. In this study, we have used database searches isolate DNA sequences encoding members chicken Oatp family and constructed a...
Seasonal reproduction depends on photoperiod‐regulated activation or suppression of the gonadal axis. Recent studies in quail have identified long‐day induced TSH‐β expression pars tuberalis (PT) as a rapid trigger activation. Thyroid‐stimulating hormone (TSH) induces type 2 deiodinase ( Dio2 ) ependymal cell layer (EC) infundibular recess to stimulate A similar mechanism is proposed sheep and mice, but experimental data temporal patterns induction are incomplete. In present study, we...
Most species living in temperate zones adapt their physiology and behavior to seasonal changes the environment by using photoperiod as a primary cue. The mechanisms underlying photoperiodic regulation of stress-related functions are not well understood. In this study, we analyzed effects on hypothalamic-pituitary-adrenal axis photoperiod-sensitive Fischer 344 rats. We first examined how affects diurnal variations plasma concentrations adrenocorticotropic hormone (ACTH) corticosterone. ACTH...
Clinical trials show that protein supplement increases infant size in malnourished populations; however, epidemiological studies high-income countries have reported mixed results. Although these findings suggest a non-linear relationship between maternal macronutrient intake and fetal growth, this has not been closely examined. We assessed the association growth among 91 637 Japanese women with singletons nation-wide cohort study using validated FFQ. The respondents answered FFQ twice, once...