A5051878782- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Antibiotic Resistance in Bacteria
- Protein Hydrolysis and Bioactive Peptides
- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
- Insect Resistance and Genetics
- Transgenic Plants and Applications
- Essential Oils and Antimicrobial Activity
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Receptor Mechanisms and Signaling
- Syphilis Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Antibiotics Pharmacokinetics and Efficacy
- Reproductive tract infections research
- Pharmacological Effects of Natural Compounds
- Invertebrate Immune Response Mechanisms
- Pediatric health and respiratory diseases
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Bacteriophages and microbial interactions
- Endodontics and Root Canal Treatments
- Chemical synthesis and alkaloids
Universidade Estadual de Goiás
2022-2024
Universidade Evangelica de Goiás
2020-2024
Universidade Católica de Brasília
2011-2024
Universidade Católica Dom Bosco
2016-2021
Biotech (Brazil)
2016-2020
Universidade Federal de Juiz de Fora
2010-2020
Universidade de Brasília
2018
Biolog (United States)
2014
Genomic (Brazil)
2012
Plant antibacterial peptides have been isolated from a wide variety of species. They consist several protein groups with different features, such as the overall charge molecule, content disulphide bonds, and structural stability under environmental stress. Although three-dimensional structures classes plant are well determined, mechanism action some these molecules is still not defined. However, further studies may provide new evidences for their function on bacterial cell wall. Therefore,...
Abstract Antibiotic-resistant infections are predicted to kill 10 million people per year by 2050, costing the global economy $100 trillion. Therefore, there is an urgent need develop alternative technologies. We have engineered a synthetic peptide called clavanin-MO, derived from marine tunicate antimicrobial peptide, which exhibits potent and immunomodulatory properties both in vitro vivo . The effectively killed panel of representative bacterial strains, including multidrug-resistant...
Significance Novel antibiotics are urgently needed to treat the ever-increasing number of drug-resistant infections. Venoms constitute a treasure trove novel potential medicines. Here, we converted peptide derived from venom into potent antimicrobials capable resolving otherwise lethal infections in mice. We demonstrate that acts directly on bacteria by targeting their membrane, while also modulating host immune response and dampening unwanted inflammation. Venom-derived molecules such as...
Human DNA is the main unit that shapes human characteristics and features such as behavior. Thus, it expected changes in (DNA mutation) influence features. Face one of which unique also dependent on his gen. In this paper, for first time we analyze variations face simultaneously. We do job by analyzing fractal dimension walk during aging. The results study show get more complex These complexities are mapped exponents face. method discussed paper can be further developed order to investigate...
Antimicrobial peptides have been found in mollusks and other sea animals. In this report, a crude extract of the marine snail Cenchritis muricatus was evaluated against human pathogens responsible for multiple deleterious effects diseases. A peptide 1485.26 Da purified by reversed-phase HPLC functionally characterized. This trypsinized sequenced MS/MS technology, sequence (SRSELIVHQR), named Cm-p1 recovered, chemically synthesized demonstrated capacity to prevent development yeasts...
Antimicrobial peptides (AMPs) are compounds that act in a wide range of physiological defensive mechanisms developed to counteract bacteria, fungi, parasites and viruses. These molecules have become increasingly important as consequence remarkable microorganism resistance common antibiotics. This report shows Escherichia coli expressing the recombinant antimicrobial peptide Pg-AMP1 previously isolated from Psidium guajava seeds. The deduced open reading frame consists 168 bp long plus...
Abstract The antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as components of the innate immune system. Recently, it was demonstrated a single AMP can perform various functions; this ability is known “peptide promiscuity.” However, little about promiscuity in plant AMPs without disulfide bonds. This study carried out to evaluate Cn ‐AMP1: promising disulfide‐free peptide with reduced size and cationic hydrophobic properties. Its activity against human pathogenic...
Inhibitors of peptidases isolated from leguminous seeds have been studied for their pharmacological properties. The present study focused on purification, biochemical characterization and anti-inflammatory anticoagulant evaluation a novel Kunitz trypsin inhibitor Erythrina velutina (EvTI). Trypsin inhibitors were purified by ammonium sulfate (30-60%), fractionation followed Trypsin-Sepharose affinity chromatography reversed-phase high performance liquid chromatography. showed molecular mass...
Healthcare-associated infections (HAIs) are causes of mortality and morbidity worldwide. The prevalence bacterial resistance to common antibiotics has increased in recent years, highlighting the need develop novel alternatives for controlling these pathogens. Pitviper venoms composed a multifaceted mixture peptides, proteins inorganic components. L-amino oxidase (LAO) is multifunctional enzyme that able different activities including antibacterial activity. In this study LAO from Bothrops...
The rapid increase in the incidence of multidrug-resistant infections today has led to enormous interest antimicrobial peptides (AMPs) as suitable compounds for developing unusual antibiotics. In this study, clavanin A, an peptide previously isolated from marine tunicate Styela clava, was selected a purposeful molecule that could be used controlling infection and further synthesized. Clavanin A vitro evaluated against Staphylococcus aureus Escherichia coli well toward L929 mouse fibroblasts...
This work provides insight into carbamazepine polymorphs (Forms I, II, III, IV, and V), with reports on the cytoprotective, exploratory, motor, CNS-depressant, anticonvulsant properties of (CBZ), formulation (CBZ-F), topiramate (TOP), oxcarbazepine (OXC), diazepam (DZP) in mice. Structural analysis highlighted significant difference molecular conformations, which directly influence physicochemical properties; density functional theory description provided indications about CBZ reactivity...
Plants have contributed over the years to discovery of various pharmacological products. Amongst enormous diversity herbs with remarkable medicinal use and further potential, here in this report we evaluated pulp extracts from Eugenia dysenterica fruits identified active principle involved such laxative activity rats. For protein isolation, were macerated an extraction solution following precipitation (NH4)2SO4 (100%). After dialysis, peptide was applied onto a reversed-phase...
A remarkable and intriguing challenge for the modern medicine consists in development of alternative therapies to avoid problem microbial resistance. The cationic antimicrobial peptides present a promise be used develop more efficient drugs applied human health. silico analysis genomic databases is strategy utilized predict therapeutic interest. Once main peptides' physical–chemical properties are already known, correlation those features search on these tool shorten identifying new...
Recently, defense peptides that are able to act against several targets have been characterized. The present work focuses on structural and functional evaluation of the peptide analogue Pa-MAP, previously isolated as an antifreeze from Pleuronectes americanus. Pa-MAP showed activities different such tumoral cells in culture (CACO-2, MCF-7 HCT-116), bacteria (Escherichia coli ATCC 8739 Staphylococcus aureus 25923), viruses (HSV-1 HSV-2) fungi (Candida parapsilosis 22019, Trichophyton...
The main bacterium associated with skin infection is Staphylococcus aureus, occurring especially in infections acquired via surgical wounds, commonly leading to lethal hospital-acquired infections, emphasizing the importance of identifying new antimicrobial compounds. Among them, cyclotides have gained interest due their high stability and multifunctional properties. Here, cycloviolacin 2 (CyO2) kalata B2 (KB2) were evaluated determinate anti-staphylococcal activities using a subcutaneous...