A5101603644- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Nanofabrication and Lithography Techniques
- Molecular Junctions and Nanostructures
- Silicone and Siloxane Chemistry
- Advanced Drug Delivery Systems
- Surface Modification and Superhydrophobicity
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Microfluidic and Capillary Electrophoresis Applications
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Advanced Biosensing Techniques and Applications
- Photopolymerization techniques and applications
- SARS-CoV-2 and COVID-19 Research
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- vaccines and immunoinformatics approaches
- Polymer composites and self-healing
- Dendrimers and Hyperbranched Polymers
- Autophagy in Disease and Therapy
Sichuan University
2016-2025
Chinese Center For Disease Control and Prevention
2024
Center for Disease Control
2024
Harbin Medical University
2024
Chengdu University
2019
University of Michigan
2009-2012
Nankai University
2005-2008
National Center for Nanoscience and Technology
2007
The facultative anaerobe Salmonella strain VNP20009 selectively colonizes into tumors following systemic injection due to its preference for the hypoxia in tumor cores. However, phase 1 clinical trial of has been terminated mainly weak antitumor effects and exhibition dose-dependent toxicity. Here, we leveraged advantages biotherapy together with polydopamine-mediated photothermal therapy order enhance efficacy toward malignant melanoma. was coated polydopamine via oxidation...
Photothermal therapy (PTT) can be an effective antitumor therapy, but it may not completely eliminate tumor cells, leading to the risk of recurrence or metastasis. Here we describe nanocarriers that allow combination involving PTT and immunotherapy. Nanocarriers are prepared by coating Al2O3 nanoparticles with non-toxic, biodegradable polydopamine, which shows high photothermal efficiency. A near-infrared laser irradiation kill majority tissues, resulting in release tumor-associated...
Hydroxychloroquine (HCQ) inhibits autophagy and therefore can sensitize some cancer cells to chemotherapy, but the high doses required limit its clinical use. Here we show that loading HCQ into liposomes (HCQ/Lip) decorated with a pH-sensitive TH-RGD targeting peptide (HCQ/Lip-TR) concentrate in B16F10 tumor lysosomes. HCQ/Lip-TR was efficiently internalized as result of ability bind ITGAV-ITGB3/integrin αvβ3 receptors highly expressed on cell surface undergo charge reversal from anionic at...
Abstract Recombinant adeno‐associated viruses (rAAVs) have emerged as promising vaccine vectors due to their enduring efficacy with a single dose. However, insufficient cellular immune responses and the random non‐specific distribution of AAVs post‐injection may hinder development AAV vaccines. Here, novel Pickering emulsion platform stabilized by biomineralized manganese nanoparticles aluminum hydroxide, which can rapidly efficiently load AAVs, is reported. This confers favorable in vivo...
Bioactive surfaces with appropriate hydrophilicity for protein immobilization can be achieved by hydrophobin II (HFBI) self-assembly on mica and polydimethylsiloxane (PDMS) surfaces. X-ray photoelectron spectroscopy water contact angle measurements illustrated that the surface wettability changed from superhydrophobic or superhydrophilic (mica) to moderately hydrophilic, which is suitable (chicken IgG) both substrate The results suggest HFBI assembly, one kind of Trichoderma reesei, may a...
Layer-by-layer assembly (LBL) can generate unique materials with high degrees of nanoscale organization and excellent mechanical, electrical, optical properties. The typical nanometer scale thicknesses restrict their utility to thin films coatings. Preparation macroscale nanocomposites will indicate a paradigm change in the practice LBL, manufacturing, multiscale nanocomponents. Such were made this study via consolidation individual LBL sheets from polyurethane. Substantial enhancement...
Nanoscale control of structure in polymer nanocomposites is critical for their performance but has been difficult to investigate systematically due the lack a suitable experimental model. In this work, we investigated role nanoparticle layer separation finite deformation response layered polyurethane− (PU−) montmorillonite (MTM) nanocomposites. A series multilayered was manufactured, with alternating PU and MTM nanolayers, using layer-by-layer manufacturing technique. The systematic...
Abstract Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor‐targeting deep‐blue nanoparticle‐based visible contrast agent described, which, for the first time, offers in vivo tumor‐specific color staining. This technology thus enables color‐guided resection real with no need extra equipment or special lighting conditions. The visual consists polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue...
We present the design and verification of a desktop system for automated production nanostructured thin films via spin-assisted layer-by-layer (spin-LBL) assembly. The utility this is demonstrated by fabricating polyvinyl alcohol/clay nanocomposites. Ellipsometry measurements demonstrate that spin-LBL method creates composites with bilayer thickness growth rate comparable to traditional dip-LBL; however, cycle time an order magnitude faster. Small angle X-ray scattering analysis shows clay...
The layer-by-layer deposition of poly(diallyldimethylammonium chloride) and poly(acrylic acid) incorporating inorganic sheets sodium montmorillonite clay leads to a stratified structure throughout the film interior, with micrometer-thick polymer complex layers thin strata (see picture; right: cross-section). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...
Abstract Whole‐cell vaccines that provide broad‐spectrum antigens have been explored for recent decades. But so far, they revealed limited success in clinical trials, possibly owing to their inefficiency targeting immune organs and antigen‐presenting cells (APCs). Herein, a facile strategy is developed convert the whole‐cell into nanoscale size promote lymphatic migration subsequent intracellular antigen presentation maximize responses. Briefly, study designs multiple delivery platform based...
Wettability improvement and bioactive interface designing of poly(dimethylsiloxane) (PDMS) are keen for its application in biodevices. Herein we developed a fully biocompatible approach achieving stable hydrophilic surfaces by modifying PDMS with hydrophobins. X-ray photoelectron spectroscopy (XPS), water contact angle (WCA), the force curve measurements demonstrated conversion surface properties from hydrophobic to hydrophilic. The patterning antigen molecules following immunoassays...
The inevitable contact of substrates with water during the traditional practice layer-by-layer assembly (LBL) creates problems for multiple potential applications LBL films in electronics. To resolve this issue, we demonstrate here possibility a process using ionic liquids (ILs), which potentially eliminates corrosion and hydration processes related to aqueous media opens additional possibilities structural control films. ILs are also considered be one best "green" processing solvents,...