A5082146540- Advanced Wireless Communication Techniques
- Wireless Communication Networks Research
- Cooperative Communication and Network Coding
- Spectroscopy and Quantum Chemical Studies
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
- Terahertz technology and applications
- Photonic and Optical Devices
- Cancer, Hypoxia, and Metabolism
- Semiconductor Quantum Structures and Devices
- Spectroscopy and Laser Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- GaN-based semiconductor devices and materials
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Electrowetting and Microfluidic Technologies
- Biosensors and Analytical Detection
- Acute Lymphoblastic Leukemia research
- Animal Disease Management and Epidemiology
- Natural product bioactivities and synthesis
- Antimicrobial Resistance in Staphylococcus
- Plant-derived Lignans Synthesis and Bioactivity
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
University of Michigan
2022-2025
Sichuan University
2023-2025
I-Shou University
2024
E-Da Hospital
2024
University of California, Riverside
1997-2024
Huazhong University of Science and Technology
2013-2024
Union Hospital
2013-2024
Rochester Institute of Technology
2020-2024
Second Affiliated Hospital of Zhejiang University
2024
Zhejiang University
2024
We have developed a novel detection system that couples clustered regularly interspaced short palindromic repeat-Cas recognition of target sequences, Cas-mediated nucleic acid probe cleavage, and quantum dots as highly sensitive reporter molecules for simple viral targets. After cleavage biotinylated ssDNA molecules, the are bound to magnetic beads. A complementary oligonucleotide dot conjugate is then added, which only hybridizes uncleaved probes on separating hybridized dots, collected...
We demonstrate a new time-domain surface phonon spectroscopy. excite coherent optical phonons with an ultrashort laser pulse and probe the free-induction decay time-resolved second-harmonic generation. For both clean GaAs (110) (100) surfaces, signals are remarkably large due to highly localized electron-phonon interaction at intrinsic sensitivity of This work suggests that oscillations may be used as probes interactions surfaces control or drive nonthermal chemical reactions.
A novel localized surface plasmon resonance (LSPR) system based on the coupling of gold nanomushrooms (AuNMs) and nanoparticles (AuNPs) is developed to enable a significant plasmonic resonant shift. The AuNP size, chemistry, concentration are characterized maximize LSPR effect. 31 nm redshift achieved when AuNMs saturated by AuNPs. This giant also increases full width spectrum explained 3D finite-difference time-domain (FDTD) calculation. In addition, this substrate packaged in microfluidic...
We first provide an overview of some the latest developments in wireless communications using multiple transmitters and receivers. point out importance SNR control fast random fading environments. For applications where large antenna arrays are not suitable, we introduce concept antennas or relays that distributed between a source destination. propose Hurwitz-Radon space-time code for relays. Each relay receives noisy baseband signal simultaneously from source. The signals (symbols) decoded...
Abstract Background Lung cancer is a leading cause of cancer-related mortality worldwide, and effective therapies are limited. worldwide with limited therapy. Sorafenib multi-tyrosine kinase inhibitor frequently used to treat numerous types malignant tumors. However, it has been demonstrated that sorafenib showed moderate antitumor activity associated several side effects in lung cancer, which restricted its clinical application. This study aimed examine the effect combination treatment...
UBE2F, a neddylation E2, neddylates CUL5 to activate cullin-RING ligase-5, upon coupling with E3 RBX2/SAG. Whether and how UBE2F controls pancreatic tumorigenesis is previously unknown. Here, we showed that essential for the growth of human cancer cells KRAS mutation. In mouse Kras
Abstract Adenocarcinoma of the ovary is fifth leading cause cancer death among American women. Most mortality results from high-grade serous ovarian carcinoma (HGS-OvCa)—a disease type resistant to conventional chemotherapy, and therein requiring urgent preclinical modeling for pharmaceutical testing. We generated a novel model by employing Ovgp1-driven Cre recombinase catalyze CRISPR-Cas9-medicated ablation Trp53, Rb1 Nf1 tumor suppressor genes in mouse (sgPRN mice). The gene encoding...
Background: Patients harboring activating mutations in epidermal growth factor receptors (EGFR) are particularly sensitive to EGFR tyrosine kinase inhibitors (TKIs). However, most patients develop an acquired resistance after a period of about 10 months. This study focuses on the therapeutic effect NVP-BEZ235, dual inhibitor phosphatidylinositol- 3-kinase/mammalian target rapamycin (PI3K/mTOR), gefitinib-resistant non-small cell lung cancer. Methods: H1975 line was validated as model by...
A series of N-(3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides were designed as the first class highly selective ZAK inhibitors. The representative compound 3h strongly inhibits kinase activity with an IC50 3.3 nM and dose-dependently suppresses activation downstream signals in vitro vivo, while it is significantly less potent for majority 403 nonmutated kinases evaluated. Compound also exhibits orally therapeutic effects on cardiac hypertrophy a spontaneous hypertensive rat model.
For ad hoc mobile networks, parallel wireless relays with space-time modulation have recently been discovered, and their potential to increase network capacity has found be significant. In this paper, we provide an analytical study of the diversity factor achievable by two orthogonal modulation. Unlike transmitters or receivers in conventional MIMO setting for which averaged bit error rate (BER) is proportional 1/SNR/sup 2/, BER shown ln(SNR)/SNR/sup 2/. This insight explains a difference...
We use Hurwitz-Radon matrices to construct a space-time code for parallel wireless mobile relays that are located anywhere between source and destination. Each relay receives sequence of symbols (i.e., baseband signals corrupted by fading noise) simultaneously from the source. These not decoded into information bits at but rearranged modulated) in their orders, amplitudes phases according code. The do exchange with each other forward modified sequences Our study shows R relays, an order...
A recent study has shown that parallel wireless relays are useful for ad hoc mobile networking. In this paper, we further explore space-time linear block codes applicable to the relays. We examine structures of signals received at a destination assisted by multiple with modulations. also provide compact form Cramer-Rao bound on channel estimation where noise variance depends parameters.
p21-activated kinase 6 (PAK6), a member of the serine/threonine family, has been reported to be involved in numerous types cancers. The present study aimed investigate role PAK6 cervical cancer. In study, expression was evaluated tissue microarrays and cell lines by using immunohistochemistry western blotting. mRNA level reverse transcription quantitative PCR. Wnt/β-catenin signaling-related protein detected blotting following short hairpin (sh)RNA-mediated knockdown or overexpression. Cell...
We have used an all-optical technique to observe optical phonons localized at a buried interface. The is based on coherent excitation of the interfacial vibrational mode by femtosecond laser irradiation and detection free-induction decay oscillation time-resolved second-harmonic generation. For native oxide-covered GaAs (100), we single-optical phonon $8.48\ifmmode\pm\else\textpm\fi{}0.04\mathrm{THz}$ few monolayers semiconductor side assignment changes in spectrum as function pump-laser...
Superhydrophobic surface-based optofluidics have been introduced to biosensors and unconventional optics with unique advantages, such as low light loss power consumption. However, most of these platforms were made planar-like microstructures nanostructures, which may cause bonding issues result in significant waveguide loss. Here, we introduce a fully enclosed superhydrophobic-based system, enabled by one-step microstereolithography procedure. Various microstructured cladding designs feature...
Induction of HO-1 protein can have both beneficial and detrimental effects for cells, including regulating proliferation apoptosis several tumours. We investigated the regulation HO-1, p38MAPK mTOR in context proliferation, cell cycle events oesophageal squamous carcinoma cells. Real-time PCR Western blots were used to determine expression levels p38MAPK, p-p38MAPK p-mTOR. MTT assays measure FACS Annexin V staining apoptosis. Proliferation Eca109 cells was inhibited induced presence...
High resolution 3D printing emerges as an alternative to microfabrication due its fine along with one-step manufacturing. Thus, it is broadly used in many fields, such biological and chemical applications. We introduce a technique the design of optofluidic probe by integrating optics microfluidics ex vivo liquid core fiber photometry. build probes various T-shapes conduct transmission measurements ray tracing simulations, where results are comparable. Through fluorescence measurements, we...