A5052105716- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Silk-based biomaterials and applications
- Animal Genetics and Reproduction
- Bioeconomy and Sustainability Development
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Collagen: Extraction and Characterization
- Vanadium and Halogenation Chemistry
- Chemistry and Chemical Engineering
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Nanoparticles: synthesis and applications
- Metal complexes synthesis and properties
- Protein Hydrolysis and Bioactive Peptides
Université de Strasbourg
2020-2024
Institut de Chimie
2024
Centre National de la Recherche Scientifique
2020-2024
ETH Zurich
2020-2023
École Polytechnique Fédérale de Lausanne
2020-2021
Abstract The billion tons of synthetic‐polymer‐based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they sustainable. Proteins sequence‐defined polymers that constantly recycled when living systems feed. Digestion is the protein depolymerization into amino acids (the monomers) followed by their re‐assembly new proteins arbitrarily different sequence and function. This breaks common recycling paradigm where...
Azomethine imines are valuable substrates for chemical synthesis in organic solvents that often require anhydrous conditions. Here, we introduce C,N-cyclic-N'-acyl azomethine (AMIs) to bioorthogonal reactions an aqueous environment. These AMIs stable under physiological conditions and react rapidly (k2 = 0.1-250 M-1 s-1, depending on pH) chemoselectively with isonitriles the presence of biological nucleophiles, including thiols. Live-cell imaging cell-surface-bound underlines...
Cγ -substituted proline derivatives are valuable tools for developing functionalized collagen peptides biological and materials investigations, yet the stereochemistry at can produce undesired steric or stereoelectronic constraints. Alkylated γ-azaproline (γ-azPro) mimetics that lack a stereogenic center γ-position of ring thus utilize invertibility nitrogen to adapt their conformation. NMR spectroscopic analyses DFT calculations highlighted how alkylated γ-azPro conformationally dynamic...
Abstract Capture and release of peptides is often a critical operation in the pathway to discovering materials with novel functions. However, best methods for efficient capture impede facile release. To overcome this challenge, we report linkers based on secondary amino alcohols after capture. These are serine (seramox) or isoserine (isoseramox) can be incorporated into during solid‐phase peptide synthesis through reductive amination. Both quantitatively cleaved within minutes under NaIO 4...
Abstract Metal ion–catalyzed overproduction of reactive oxygen species (ROS) is believed to contribute significantly oxidative stress and be involved in several biological processes, from immune defense development diseases. Among the essential metal ions, copper one most efficient catalysts ROS production presence O2 a physiological reducing agent such as ascorbate. To control this chemistry, Cu ions are tightly coordinated biomolecules. Free or loosely bound generally avoided prevent their...
Abstract Capture and release of peptides is often a critical operation in the pathway to discovering materials with novel functions. However, best methods for efficient capture impede facile release. To overcome this challenge, we report linkers based on secondary amino alcohols after capture. These are serine (seramox) or isoserine (isoseramox) can be incorporated into during solid‐phase peptide synthesis through reductive amination. Both quantitatively cleaved within minutes under NaIO 4...
Abstract The billion tons of synthetic polymer-based materials ( i.e. plastics) produced every year are one the greatest challenges that humanity has to face. Nature produces even more natural polymers, yet they sustainable. For example, proteins sequence-defined constantly recycled when living systems feed. Indeed, digestion is protein depolymerization into amino acids monomers) followed by their re-assembly new arbitrarily different sequence and function. This process breaks a common...
Protein Recycling In article number 2104581, Sebastian Josef Maerkl, Francesco Stellacci, and co-workers introduce an idealized representation of nature-inspired circular-economy recycling (NaCRe) for proteins, a approach where generic mixtures protein-based materials are depolymerized into their constituent amino acids, which in turn used as the only source monomers to produce new that unrelated parent ones, outside living organisms. Illustration created by SciencePicture.Co.