A5023866180- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Refrigeration and Air Conditioning Technologies
- Anesthesia and Sedative Agents
- Abdominal Surgery and Complications
- Sepsis Diagnosis and Treatment
- Effects of Environmental Stressors on Livestock
- Simulation-Based Education in Healthcare
- Occupational Health and Performance
- Ethics and Social Impacts of AI
- Imbalanced Data Classification Techniques
- Connective Tissue Growth Factor Research
- Statistical Methods and Inference
University Hospital Carl Gustav Carus
2014-2024
Technische Universität Dresden
2014-2024
Dräger (Germany)
2023
University of Genoa
2016-2021
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2020-2021
University of Milan
2021
Outcomes Research Consortium
2021
Mahidol Oxford Tropical Medicine Research Unit
2021
Mahidol University
2021
University of Foggia
2018
Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their relative contribution to inflammation in injury is not well established. The aim of this study was determine the impact volutrauma on distribution experimental acute respiratory distress syndrome. Design: Laboratory investigation. Setting: University-hospital research facility. Subjects: Ten pigs (five per group; 34.7–49.9 kg) Interventions: Animals were anesthetized intubated, saline lavage performed....
Harmful effects of spontaneous breathing have been shown in experimental severe acute respiratory distress syndrome (ARDS). However, the clinical setting, respiration has indicated only mild ARDS. To date, no study compared assisted with those fully controlled mechanical ventilation at different levels positive end-expiratory pressure (PEEP) on lung injury ARDS.To compare support (PSV) pressure-controlled (PCV) function, histology and biological markers two PEEP ARDS rats.Randomised...
To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.Laboratory investigation.University hospital research facility.Twenty-four pigs (28.1-58.2 kg).In anesthetized animals, intrapleural sensors were placed thoracoscopically ventral, dorsal, caudal regions left hemithorax. Lung injury was induced saline lavage followed...
This study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure.Thirteen failure were enrolled this monocentric, randomized crossover study. Patients PSV, for one hour each, random sequence. Pressure was titrated to reach tidal volumes approximately 8 mL/kg both modes. The level positive end-expiratory fraction inspired oxygen kept unchanged...
The biologic effects of variable ventilation may depend on the etiology acute respiratory distress syndrome. We compared and conventional in experimental pulmonary extrapulmonary syndrome.Prospective, randomized, controlled study.University research laboratory.Twenty-four Wistar rats.Acute syndrome was induced by Escherichia coli lipopolysaccharide administered intratracheally (pulmonary syndrome, n = 12) or intraperitoneally (extrapulmonary 12). After 24 hours, animals were randomly...
In the 2014 PROtective Ventilation using HIgh versus LOw positive end-expiratory pressure (PROVHILO) trial, intraoperative low tidal volume ventilation with high (PEEP = 12 cm H2O) and lung recruitment maneuvers did not decrease postoperative pulmonary complications when compared to PEEP (0-2 approach without breaths. However, effects of on compliance remain poorly understood. We hypothesized that higher leads a dominance intratidal overdistension, whereas lower results in...
Mechanical ventilation can lead to lung biotrauma when mechanical stress exceeds safety thresholds. The authors investigated whether the duration of stress, that is, impact a versus time product (STP), influences biotrauma. hypothesized higher STP levels are associated with increased inflammation and alveolar epithelial endothelial cell injury.In 46 rats, Escherichia coli lipopolysaccharide (acute inflammation) or saline (control) was administered intratracheally. Both groups were...
Intraoperative mechanical ventilation may yield lung injury. To date, there is no consensus regarding the best ventilator strategy for abdominal surgery. We aimed to investigate impact of strategies used in 2 recent trials (Intraoperative Protective Ventilation [IMPROVE] trial and using High versus Low PEEP [PROVHILO] trial) on driving pressure (ΔPRS), power, damage a model open surgery.Thirty-five Wistar rats were used, which 28 anesthetized, laparotomy was performed with standardized bowel...
Mechanical ventilation has the potential to increase inflammation in both healthy and injured lungs. Several animal studies have shown that variable recruits lungs reduces inflammation. However, it is unclear which cellular mechanisms are involved those findings. We hypothesized stretch of LPS-stimulated alveolar epithelial cells (AECs) production pro-inflammatory cytokines compared non-variable stretch. AECs were subjected or cyclic (sinusoidal pattern), with without LPS stimulation. The...
To investigate the role of ultraprotective mechanical ventilation (UP-MV) and extracorporeal carbon dioxide removal with without spontaneous breathing (SB) to improve respiratory function lung protection in experimental severe acute distress syndrome.Severe syndrome was induced by saline lavage (MV) higher tidal volume (VT) 28 anesthetized pigs (32.8 52.5 kg). Animals (n = 7 per group) were randomly assigned 6 h MV (airway pressure release ventilation) with: (1) conventional P-MV VT ≈6 ml/kg...
During anaesthesia awareness and nociception are serious complications that may further lead to haemodynamic instability. Specific monitoring of depth hypnosis analgesia based on heart rate variability (HRV) analysis is eligible improve patient safety reduce efforts in post-operative care. Consequently, this we assess the applicability HRV parameters during surgical interventions with standardized intravenous propofol-remifentanil-anaesthesia. Peri-operative electrocardiograms were recorded...
Background Measuring esophageal pressure (Pes) using an air-filled balloon catheter (BC) is the common approach to estimate pleural and related parameters. However, Pes not routinely measured in mechanically ventilated patients, partly due technical practical limitations difficulties. This study aimed at comparing conventional BC with two alternative methods for measurement, liquid-filled catheters without (LFC AFC), during mechanical ventilation spontaneous breathing activity. Seven female...
Abstract Remote imaging photoplethysmography (iPPG) senses the cardiac pulse in outer skin layers and is responsive to mean arterial pressure critically ill patients. Whether iPPG sufficiently sensitive monitor cutaneous perfusion not known. This study aimed at determining response of changes measured by Laser speckle (LSI). Thirty-seven volunteers were engaged a cognitive test known evoke autonomic nervous activity Heat test. Simultaneous measurements LSI taken baseline during challenges. A...
Abstract Background Flow-controlled ventilation (FCV) allows expiratory flow control, reducing the collapse of airways during expiration. The performance FCV one-lung (OLV) under intravascular normo- and hypovolaemia is currently unknown. In this explorative study, we hypothesised that OLV with improves PaO 2 reduces mechanical power compared to volume-controlled (VCV). Sixteen juvenile pigs were randomly assigned one two groups: (1) normovolaemia ( n = 8) (2) 8). To mimic inflammation due...
In experimental elastase-induced emphysema, mechanical ventilation with variable tidal volumes (VT) set to 30% coefficient of variation (CV) may result in more homogenous distribution, but might also impair right heart function. We hypothesized that a different CV setting could improve both lung and cardiovascular Therefore, we investigated the effects levels VT variability on cardiorespiratory function, histology, gene expression biomarkers associated inflammation, fibrogenesis, epithelial...
Emphysema is characterized by loss of lung tissue elasticity and destruction structures supporting alveoli capillaries. The impact mechanical ventilation strategies on ventilator-induced injury (VILI) in emphysema poorly defined. New ventilator should be developed to minimize VILI emphysema. present study was divided into two protocols: 1) characterization an elastase-induced model rats identification the time point greatest cardiorespiratory impairment, defined as a high specific elastance...
Background: Mechanical ventilation (MV) may initiate or worsen lung injury, so-called ventilator-induced injury (VILI). Although different mechanisms of VILI have been identified, research mainly focused on single ventilator parameters. The mechanical power (MP) summarizes the potentially damaging effects parameters in one variable and has shown to be associated with damage. However, date, association MP pulmonary neutrophilic inflammation, as assessed by positron-emission tomography (PET),...