A5101627219- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Asthma and respiratory diseases
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
Second Affiliated Hospital of Jilin University
2020-2025
Jinan Stomatological Hospital
2019-2022
Beijing Hospital
2018
Background/Aims: Recent studies have suggested that changes in non-coding mRNA play a key role the progression of non-alcoholic fatty liver disease (NAFLD). Metformin is now recommended and effective for treatment NAFLD. We hope current analyses transcriptome will provide better presentation potential roles mRNAs long RNAs (lncRNAs) underlie NAFLD metformin intervention. Methods: The present study mainly analysed coding after application five-week Liver samples from three groups mice were...
Background An evidence-based eHealth education tool was developed for patients with knee osteoarthritis (KOA). This study aimed to evaluate the long-term effectiveness on patient knowledge level and analyzed patient's satisfaction proposed tool. Methods A two-arm randomized controlled trial performed, 218 KOA allocated 1:1 two groups by balanced block randomization. Both received usual care additionally, group used during process. The primary outcome measure validated questionnaire (PKQ-OA)....
Tongue squamous cell carcinoma (TSCC) accounts for one-third of oral cancers. Previous studies had reported that lncRNA/miRNA regulated the biological behaviors different cancer cells. However, mechanisms PART1 in regulating tumorigenesis and TSCC development via targeting miR-503-5p not been studied.The expressions tissues cultured lines were detected by qRT-PCR. StarBase 3.0 was used to predict binding sites PART1, then dual-luciferase assay RNA pull-down executed confirm whether a target...
Osteosarcoma is a highly aggressive cancer common in children and adolescents. There still lack of effective treatments for metastatic or recurrent osteosarcoma. The role long non-coding RNAs (lncRNAs) osteosarcoma has gradually attracted attention. Here, we identified lncRNAs that were abnormally expressed through analyzing the sequencing data tissues selected upregulated lncRNA MELTF-AS1 detailed study. qRT-PCR analysis showed expression was increased cells, high indicated poor prognosis...
To detect the expressions of long intergenic non-protein coding ribonucleic acid 1638 (LINC01638) in non-small cell lung cancer (NSCLC) tissues and cells, to explore biological function LINC01638 underlying mechanism its high expression.The relative expression levels NSCLC cells were determined via quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR). The interference sequences designed, efficiency was measured using qRT-PCR. influences on proliferation ability, cycle...
Accumulating amount of evidence has highlighted the important roles long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) in tumor pathogenesis. However, non coding lncRNA-related ceRNA network intrahepatic cholangiocarcinoma (ICC) still remain enigmatic. The current study aims to identify prognostic factors ICC. transcriptome sequencing data lncRNAs, messenger RNA (mRNA) and microRNA (miR) were downloaded from SRA TCGA databases. Differentially expressed lncRNAs...
Thyroid cancer is a commonly diagnosed endocrine malignancy with increasing incidence worldwide. Long noncoding RNAs (lncRNAs) are known to function in the invasion and metastasis of thyroid cancer. According GSE66783 microarray dataset, long intergenic nonprotein coding RNA 284 (LINC00284) aberrantly upregulated tissues. However, information regarding specific role LINC00284 remains elusive. Therefore, current study set out determine development cancer, along an investigation underlying...
This study aimed to explore the role of circular-CDC like kinase 1 (circ-CLK1) in pathogenesis oral squamous cell carcinoma (OSCC). Circ-CLK1 expression levels were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The effects circ-CLK1 knockdown on viability and apoptosis OSCC cells determined using counting kit-8 (CCK-8) assay, EdU staining, flow cytometry, Western blotting. StarBase TargetScan used predict targeting relationships, which then confirmed by...
BACKGROUNDPeriodontitis is a chronic inflammation of periodontal supporting tissue caused by local factors.Periodontal surgery can change the gene expression peripheral blood mononuclear cells.However, little known about potential mechanism surgical treatment for periodontitis. AIMTo explore molecular
Abstract Background: Accumulating amount of evidence has highlighted the important roles long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) in tumor pathogenesis. However, non coding lncRNA-related ceRNA network intrahepatic cholangiocarcinoma (ICC) still remain enigmatic. The current study aims to identify prognostic factors ICC.Methods: transcriptome sequencing data lncRNAs, messenger RNA (mRNA) and microRNA (miR) were downloaded from SRA TCGA databases. Differentially...
Abstract Background Accumulating evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) in tumor biology. However, cancer non coding lncRNA-related ceRNA network intrahepatic cholangiocarcinoma (ICC) remain enigmatic. The current study aims to identify prognostic factors ICC. Methods transcriptome sequencing data lncRNAs, messenger RNA (mRNA) and microRNA (miR) were downloaded from SRA, TCGA database respectively. Differentially...