A5015558605- Advanced biosensing and bioanalysis techniques
- Graphene research and applications
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Extracellular vesicles in disease
- Nanowire Synthesis and Applications
Imperial College London
2021-2023
Imperial Valley College
2023
Biosensors based on graphene field effect transistors (GFETs) have the potential to enable development of point-of-care diagnostic tools for early stage disease detection. However, issues with reproducibility and manufacturing yields sensors, but also Debye screening unwanted detection nonspecific species, prevented wider clinical use technology. Here, we demonstrate that our wafer-scalable GFETs array platform enables meaningful results. As a case study high relevance, an accurate robust...
Graphene field-effect transistors (GFETs) are suitable building blocks for high-performance electrical biosensors, because graphene inherently exhibits a strong response to charged biomolecules on its surface. However, achieving ultralow limit-of-detection (LoD) is limited by sensor time and screening effect. Herein, we demonstrate that the detection limit of GFET biosensors can be improved significantly decorating uncovered area with carbon dots (CDs). The developed CDs-GFET used exosome...
Graphene field-effect transistor (GFET) biosensors exhibit high sensitivity due to a large surface-to-volume ratio and the of Fermi level presence charged biomolecules near surface. For most reported GFET biosensors, bulky external reference electrodes are used which prevent their full-scale chip integration contribute higher costs per test. In this study, arrays with on-chip integrated liquid were employed for COVID-19 detection functionalized either antibody or aptamer selectively bind...
Abstract The appropriate orientation of antibodies on the graphene surface is critical for high performance biosensors. In this paper, we show that a predominantly vertical to can be achieved by functionalizing with tetrakis (4-carboxyphenyl) porphyrin (TCPP). We used method detect exosome biomarkers using field effect transistor (GFET) platform, and two orders magnitude improvement in detection limit GFET biosensor compared conventionally 1-pyrene butanoic acid succinimidyl ester (PBASE)....