A5005975117- Natural Language Processing Techniques
- Cancer-related molecular mechanisms research
- Topic Modeling
- Bone Tissue Engineering Materials
- Higher Education and Teaching Methods
- Bone and Dental Protein Studies
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Protein Tyrosine Phosphatases
- Mesenchymal stem cell research
- Dental materials and restorations
- Bone health and treatments
- Endoplasmic Reticulum Stress and Disease
- Recommender Systems and Techniques
- Oral microbiology and periodontitis research
- Advanced Text Analysis Techniques
- MicroRNA in disease regulation
- Semantic Web and Ontologies
- Saffron Plant Research Studies
- Education and Learning Interventions
- Orthopaedic implants and arthroplasty
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Photodynamic Therapy Research Studies
- Web Data Mining and Analysis
Shandong University
2016-2024
Minzu University of China
2020-2024
University of Science and Technology Beijing
2024
Beijing Normal University
2002-2022
Analogic (United States)
2021
Stomatology Hospital
2020
Sichuan University
2011-2016
State Key Laboratory of Oral Diseases
2016
Zhengzhou University of Light Industry
2010
Zhengzhou University
2008
Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator produced from polyunsaturated fatty acids and believed to have antioxidant anti-inflammatory properties. The objective of this study was estimate MaR1's impact on type 2 diabetic osteoporosis (T2DOP) its pharmacological mode action. An in vitro high-glucose model the osteoblast cell line MC3T3-E1 constructed stimulated with MaR1. Type rats were used establish vivo models calvarial defects treated situ results revealed that, aside...
Abstract Objectives Peripheral nerve injuries are a common occurrence, resulting in considerable patient suffering; it also represents major economic burden on society. To improve treatment options following peripheral injuries, scientists aim to find way promote Schwann cell ( SC ) myelination help nerves carry out their functions effectively. In this study, we investigated ability of s, regulated by co‐culture with adipose‐derived stem cells ASC s) or low‐intensity pulsed ultrasound LIPUS...
Abstract Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress poor osteogenesis peri-implant bone area. Genipin is major component gardenia fruits with strong antioxidant, anti-inflammation, antidiabetic actions, it also can activate quality control via pathway. The purpose this study was to investigate effects genipin insulin...
Abstract Background Periodontal ligament stem cells (PDLSCs) are important seed for tissue engineering to realize the regeneration of alveolar bone. Understanding gene regulatory mechanisms osteogenic lineage differentiation in PDLSCs will facilitate PDLSC-based bone regeneration. However, these molecular signals have not been clarified. Methods To screen potential regulators differentiation, expression profiles undifferentiated and osteodifferentiated were compared by microarray...
Word2vec is often used in text sentiment analysis to generate word vector, which maps the same into vector. Although plays a very good effect initial model training task, it still cannot solve problems of polysemy and new use old words, leads inaccurate extracted features affects final classification results. In this paper, BERT was vectorize review tourist attractions, fusion attention mechanism long short-term memory were extract emotional for at feature extraction layer. The accuracy...
The osseointegration process of implant is seriously impaired in type 2 diabetes mellitus (T2DM) that causes high failure rate, and insufficiency exists current insulin therapy, creating a demand for new bone-synergistic agent. Cinaciguat, novel soluble guanylate cyclase (sGC) activator, plays vital role glucose metabolism, inflammation control bone regeneration. We hypothesized the combined application cinaciguat could reverse poor diabetes. To test this hypothesis, streptozotocin-induced...
Periodontitis is one of the severe complications in diabetic patients and gingival epithelium plays an initial role on onset progression this disease. However potential mechanism yet sufficiently understood. Meanwhile, research correlational experimental animal models was also insufficient. Here, we established periodontitis with type 2 diabetes db/db Tallyho/JngJ (TH) mice 1 streptozotocin induced C57BL/6J (STZ-C57) by oral infection periodontal pathogen Porphyromonas gingivalis W50. We...
Type 2 diabetes mellitus (T2DM) is considered to compromise implant osseointegration. Protein tyrosine phosphatase non-receptor type (PTPN2) regulates glucose metabolism, systemic inflammation, and bone regeneration. This study aimed investigate the role of PTPN2 in osseointegration T2DM explore potential mechanisms. Streptozotocin-induced diabetic rats received surgery, with or without local overexpression for three months, was examined by histological evaluation, micro-CT analysis,...
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) is an important protection factor for diabetes and periodontitis, but the underlying mechanism remains elusive. This study aimed to identify substrate of PTPN2 in mediating beneficial effects 25-Hydroxyvitamin D3 (25(OH)2D3 ) on diabetic periodontitis. 25(OH)2D3 photo-affinity probe was synthesized with minimalist linker its efficacy inhibit alveolar bone loss, inflammation evaluated periodontitis mice. The used pull down lysates...
One potential solution to the problem of information overload is recommendation system, and main task system based on user portrait combine product, by mapping product portrait, combining association rule mining reordering algorithm, a personalized list obtained. Not only can help users find valuable for themselves, but also make displayed in front interested users, so as achieve win-win situation between consumers producers.
Diabetes-induced advanced glycation end products (AGEs) overproduction would result in compromised osseointegration of titanium implant and high rate implantation failure. 1α,25-dihydroxyvitamin D3 (1,25VD3) plays a vital role osteogenesis, whereas its effects on the underlying mechanism are unclear. The purpose this study was to investigate that 1,25VD3 might promote defensive ability through suppressing AGEs/RAGE type 2 diabetes mellitus. In animal study, streptozotocin-induced diabetic...
Dental caries is an acid-related disease. Current anti-caries agents mainly focus on the bacteriostatic effect in a neutral environment and do not target acid-resistant microorganisms related to acidic milieus. To assess vitro antibacterial activities of bedaquiline against oral pathogens Streptococcus mutans, sanguinis, salivarius were used prepare mono-/multiple suspension biofilm. The MIC IC50 S. mutans determined by broth microdilution method. Bedaquiline was compared regarding (i)...
The influence of alumina addition on mechanical behavior and fracture properties all-ceramics zirconia dental materials was evaluated. Samples containing 0, 5, 10, 15 wt.% Al 2 O 3 particles were prepared by cold isostatic pressing (200 MPa) sintered at 1500°C for 5 h. Commercial powders investigated bulk density phase formation using Archimedes principle X-ray diffraction (XRD). Bending strength load determined room temperature three-point bending test. In order to study the fracture, we...