A5014394380- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Health and Medical Research Impacts
- Prostate Cancer Diagnosis and Treatment
- Radiation Effects in Electronics
- Advances in Oncology and Radiotherapy
- Boron Compounds in Chemistry
- Nuclear Physics and Applications
- Optical Coherence Tomography Applications
- Effects of Radiation Exposure
- Radiation Detection and Scintillator Technologies
- Ocular Oncology and Treatments
- Radiation Effects and Dosimetry
- Glioma Diagnosis and Treatment
- Retinal and Macular Surgery
- Integrated Circuits and Semiconductor Failure Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Breast Cancer Treatment Studies
- bioluminescence and chemiluminescence research
- Biomedical and Engineering Education
- Clinical Reasoning and Diagnostic Skills
- Lung Cancer Diagnosis and Treatment
- Academic Publishing and Open Access
Thompson Cancer Survival Center
2022-2025
Provision Center for Proton Therapy
2016-2021
Washington University in St. Louis
2015
Abstract The purpose of this study was to evaluate intrafraction prostate motion in patients treated with proton therapy and an endorectal balloon or a hydrogel spacer using orthogonal x‐rays acquired before after each treatment field. This evaluated 10 (662 fields throughout treatment) daily ( ERB ) 16 (840 GEL without . Patient shifts were recorded field, correlated time, x‐ray imaging implanted fiducial alignment. For shift, X, Y, Z, 3D vector calculated determine the positional change....
The aim of this study is to validate the RayStation Monte Carlo (MC) dose algorithm using animal tissue neck phantoms and a water breast phantom.Three anthropomorphic were used in clinical setting test MC algorithm. We two real necks that cut workable shape while frozen then thawed before being CT scanned. Secondly, we made patient phantom prosthesis filled with placed on flat surface. Dose distributions measured MatriXX PT device.The doses compared exceptionally well calculated by...
The purpose of this study was to investigate the consistency rectal sparing using multiple periodic quality assurance computerized tomography imaging scans (QACT) obtained during course proton therapy for patients with prostate cancer treated a hydrogel spacer. Forty-one low- and intermediate-risk image-guided spacer were analyzed. To assess reproducibility spacer, three four QACTs performed each patient on day 1 weeks 1, 3, 5 treatment. treatment plan calculated QACT rectum V90%, V75%,...
To measure, in the setting of typical passively scattered proton craniospinal irradiation (CSI) treatment, secondary neutron spectra, and use these spectra to calculate dose equivalents for both internal external neutrons delivered via a Mevion single-room compact system.Secondary were measured using extended-range Bonner spheres whole brain, upper spine, lower spine fields. The detector used can discriminate over entire range energy spectrum encountered therapy. separately assess internally...
Our purposes are to compare the accuracy of RaySearch's analytical pencil beam (APB) and Monte Carlo (MC) algorithms for clinical proton therapy present validation data using a novel animal tissue lung phantom.We constructed realistic phantom composed rack lamb resting on stack rectangular natural cork slabs simulating tissue. The tumor was simulated 70% lean ground meat inserted in spherical hole with diameter 40 ± 5 mm carved into slabs. A single-field plan an anterior two-field two...
It is well known in proton therapy that the relative biological effectiveness (RBE) not constant across entire Bragg peak, with higher RBE at distal end of peak due to linear energy transfer (LET). Treatment planning systems are moving toward LET optimization mitigate this potentially impact a track end. However, using simple script, users can begin simulate process by deleting spots from critical structures during optimization. In most cases, nominal target coverage and plan robustness...
The purpose of this work was to reduce the severity radiation dermatitis for breast cancer patients receiving pencil beam scanning proton therapy. hypothesis that eliminating spots (SpotDelete) in 0.5 cm skin rind would potentially higher relative biological effectiveness (RBE) known occur at Bragg Peak.
In the evolving progress of academic medicine, metrics by which we measure success are both crucial and contentious. Among these, Journal Impact Factor (JIF) has long been a dominant metric, often serving as shorthand for quality significance research. For many institutions, JIF plays pivotal role in decisions regarding promotion, tenure, funding, positioning it key indicator achievement. However, delve deeper into complexities scholarly impact, questions arise: Is truly fair an individual...
Pencil beam scanning (PBS) proton therapy offers dosimetric advantages for several treatment sites, including head and neck (H&N). However, to achieve the optimal target coverage robustness, these plans can be complex time consuming develop optimize. Automating planning process ensure a high-quality standardized plan, reduce burden planner, decrease time-to-treatment. We utilized in-house scripting automate four-field multi-field optimization (MFO) H&N technique.Ten bilateral patients were...
Purpose: Rectal hydrogel spacer has been shown to improve rectal sparing in prostate radiotherapy. The purpose of this study was determine the reproducibility throughout treatment patients undergoing proton therapy. Methods: At our facility, cancer are treated with pencil beam scanning therapy, utilizing an endorectal balloon (ERB) or (Gel) “SpaceOAR” implant. All were a full bladder and empty rectum (low residue diet stool softeners). A quality assurance CT (QACT) performed periodically...
Purpose: Current precision of small animal and cell micro‐irradiators has continuously increased during the past years. Currently, preclinical irradiators can deliver sub‐millimeter fields with micrometric but there are no water equivalent dosimeters to determine field profiles dose in orthovoltage range energies resolution precision. We have developed a fiber based micro‐dosimeter dosimetric accuracy required for radiobiological research. Methods: constructed two prototypes micro‐dosimeters...
treatment QA and the minimum number of clinical couples (DLG,TF) needed to ensure acceptance all plans.