A5103037061- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Cardiac Ischemia and Reperfusion
- Allergic Rhinitis and Sensitization
- Cardiovascular Function and Risk Factors
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Immune responses and vaccinations
- Coenzyme Q10 studies and effects
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Chemotherapy-induced cardiotoxicity and mitigation
- Head and Neck Surgical Oncology
- Ion channel regulation and function
- Phytochemistry and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Calpain Protease Function and Regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phytoestrogen effects and research
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Stellenbosch University
2009-2017
Nantong University
2012
Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) involved in occurrence and development CRSwNP. T-cell immunoglobulin domain mucin 4 (TIM-4) closely related chronic inflammation, but its mechanism CRSwNP poorly understood. In our study, we found that TIM-4 was increased sinonasal mucosa patients and, especially, macrophages. positively correlated α-SMA negatively E-cadherin CRS....
The aim of this study was to investigate the effects lysine restriction on inflammatory responses in piglets. 38 male piglets with similar body weight 9.62 kg were randomly divided into control group (basal diet) and lysine-restricted (diet containing 70% diet). results showed that increased serum concentration IgG an IgM. Piglets fed diet exhibited overexpression interleukin-8 (IL-8) kidney (P < 0.05) IL-6 IL-4 spleen 0.05). mRNA abundances IL-10 liver significantly lower compared group....
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic (non-eCRSwNP) by tissue biopsy, which is difficult to perform preoperatively. Clinical biomarkers have predictive value for the classification of CRSwNP. We aimed evaluate application artificial neural network (ANN) modeling in distinguishing different endotypes based on clinical biomarkers.Clinical parameters were collected from 109 patients, their ability was...
Introduction: Osthole, a naturally occurring coumarin derivative, has been isolated from the traditional Chinese medicinal herb Cnidium monnieri. This compound exhibits range of pharmacological properties, including anticancer, antioxidant, anti-inflammatory, and immunomodulatory effects. The objective this study was to investigate role osthole in tissue remodeling chronic rhinosinusitis with nasal polyp (CRSwNP). Methods: effects on (NP) formation were examined within mouse model NPs...
Previous studies have shown the role of ten-eleven translocation 2 (TET2) in CD4+ T cells. However, its function cells under allergic inflammation is unclear. We aimed to investigate epigenomic distribution DNA 5-hydroxymethylcytosine (5hmC) and TET2 rhinitis (AR).The hMeDIP-seq was performed identify sequences with 5hmC deposition AR patients. Tet2-deficient or wild type mice were stimulated ovalbumin (OVA) develop an mouse model. The histopathology nasal mucosae, Th1/Th2/Treg/Th17 cell...
Allergic rhinitis (AR) is an inflammatory disorder of the nose caused by immunoglobulin E (IgE)-mediated immune response to allergens. Apart from typical symptoms sneezing, itching, rhinorrhea, and nasal congestion, behavioral complications were also reported be associated with progression AR, such as cognitive deficits, mood changes, memory decline, attention deficiency, poor school performance, anxiety, depression. Recent human studies have suggested that alterations in brain function...
Allergic rhinitis (AR) is a common otolaryngology disease and one of the clinical causes olfactory dysfunction (OD). The bulb serves as transfer station for information transmission, alleviating its neuroinflammation may be expected to improve AR-induced OD. Recent studies have suggested that dopamine D2 receptor acts key target in regulating immune functions neuroinflammatory reaction. However, effect on still unknown.
Reports on the effect of age and obesity myocardial ischaemia/reperfusion (I/R) injury ischaemic preconditioning are contradictory. The aim this study was to re-evaluate effects diet-induced (DIO) I/R potential. Four groups Wistar male rats were used: age-matched controls (AMC) receiving standard rat chow for (i) 16 weeks (ii) months respectively; DIO a sucrose-supplemented diet (iii) (iv) respectively. ages 22 ("young") 17 ("middle-aged") at time experimentation. Isolated perfused working...
Allergic rhinitis (AR) represents a hallmark of obvious hypersensitivity with an imbalance immune responses, including abnormal macrophage activity in local tissues. It has been reported that alternatively activated macrophages (M2) may contribute to allergic pathogenesis. Ten-eleven translocation (Tet) enzymes can oxidize 5-methylcytosine (m5C) mRNA, implying the epigenetic regulation post-transcriptional RNA modification. Our previous study suggested decreased Tet2 impairs function...
Abstract Background: Allergic rhinitis (AR) is a common chronic allergic disease of the upper airway that not only causes peripheral inflammation, but also induces neuroinflammation in hippocampus, prefrontal cortex, olfactory bulb and other brain areas. Recent studies have suggested dopamine D2 receptor acts as key target regulating immune functions neuroinflammatory reaction, which may be promising for AR-induced dysfunction (OD). Methods: An AR mouse model with OD induced by ovalbumin...
Objective: To investigate the effects of dopamine on olfactory function and inflammatory injury bulb in mice with allergic rhinitis (AR). Methods: AR mouse model was established by using ovalbumin (OVA), were divided into two groups: dysfunction (OD) group without OD through buried food pellet test (BFPT). The randomly 2 groups, OVA combined (3, 6, 9 12 days, respectively) or an equal amount PBS (the same treatment time) administered nasally. evaluated BFPT. number eosinophils goblet cells...
Insulin resistance decreases glucose uptake, alters lipid metabolism and impairs PKB-dependent signaling in its target tissues. In view of the myocardial dependence on glycolysis during energy deficiency, insulin may exacerbate harmful effects ischaemia. We hypothesize that obesity-induced affects functional recovery activation PKB, JNK, ERK PTEN early reperfusion. Methods: was induced by feeding rats a high calorie diet for 16 weeks. Hearts from (D) age-matched controls (C) were subjected...