A5054883820- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood donation and transfusion practices
- COVID-19 Clinical Research Studies
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- SARS-CoV-2 and COVID-19 Research
- Meta-analysis and systematic reviews
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Impact on Reproduction
- Artificial Intelligence in Healthcare and Education
- Cardiac Arrest and Resuscitation
- Blood groups and transfusion
- Emergency and Acute Care Studies
- Clinical Laboratory Practices and Quality Control
- Anesthesia and Sedative Agents
- Spine and Intervertebral Disc Pathology
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Pain Management and Treatment
- Hemostasis and retained surgical items
- Complement system in diseases
- Topic Modeling
- SARS-CoV-2 detection and testing
University of Virginia
2025
University of Wisconsin–Madison
2016-2024
Animal and Plant Health Inspection Service
2024
UW Health University Hospital
2016-2023
University of Washington
2021
Chongqing Electromechanical Holdings (China)
2021
Committee on Publication Ethics
2016-2021
Seattle University
2017-2020
Emerald Coast Science Center
2018
Madison Group (United States)
2017
Importance Red blood cell transfusion is a common medical intervention with benefits and harms. Objective To provide recommendations for use of red in adults children. Evidence Review Standards trustworthy guidelines were followed, including using Grading Recommendations Assessment, Development Evaluation methods, managing conflicts interest, making values preferences explicit. from systematic reviews randomized controlled trials was reviewed. Findings For adults, 45 20 599 participants...
The isolated forearm technique allows assessment of consciousness the external world (connected consciousness) through a verbal command to move hand (of tourniquet-isolated arm) during intended general anesthesia. Previous data suggest that incidence connected may approach 37% after noxious stimulus. authors conducted an international, multicenter, pragmatic study establish responsiveness intubation in routine practice.Two hundred sixty adult patients were recruited at six sites into...
BACKGROUND: Admission platelet (PLT) counts are known to be associated with all‐cause mortality for seriously injured patients admitted a trauma center. The course of subsequent PLT counts, their implications, and the effects therapy less well known. STUDY DESIGN AND METHODS: Trauma center who were directly from scene injury, received 1 or more units uncrossmatched red blood cells in first hour care, survived at least 15 minutes, had count measured analyzed association admission 24 hours...
Importance Platelet transfusion is a frequent procedure with benefits and risks. Objective To provide recommendations in adult pediatric populations whom platelet transfusions are commonly performed. Evidence Review Grading of Recommendations Assessment Development Evaluation (GRADE) methodology was applied to findings from 21 randomized trials 13 observational studies contexts limited clinical trial data. Transfusion strategies using fewer (restrictive) vs greater (liberal) amounts...
The authors have disclosed no conflicts of interest.
BACKGROUND: Focused rapid echocardiographic evaluation (FREE) is a comprehensive transthoracic echocardiogram tailored for the intensive care unit. It assesses both cardiac index (CI) and left ventricular ejection fraction (EF). FREE vascular catheter-derived CI was compared, ability of to detect moderate severe dysfunction (EF <40%) determined. METHODS: quality assurance database reviewed identify patients who had hemodynamic catheter. RESULTS: Of 507 FREEs, 115 were identified, 25...
SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus, especially if used...
Abstract Introduction The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is responsible for a worldwide pandemic. While the medical community understands mode of viral transmission, less known about how long shedding occurs once symptoms have resolved. Our objective was to determine SARS‐CoV‐2 remains detectable following self‐reporting symptom resolution. Methods This study approved by University Wisconsin Institutional Review Board. A cohort patients who...
Large language models (LLMs) excel at answering knowledge-based questions. Many aspects of blood banking and transfusion medicine involve no direct patient care require only knowledge judgment. We hypothesized that public LLMs could perform such tasks with accuracy precision.We presented three sets to publicly-available (Bard, GPT-3.5, GPT-4). The first was review short case presentations then decide if a red cell indicated. second task answer set consultation questions common in clinical...
Artificial intelligence and large language models (LLMs) have emerged as potentially disruptive technologies in healthcare. In this study GPT-3.5, an accessible LLM, was assessed for its accuracy reliability performing guideline-based evaluation of neuraxial bleeding risk hypothetical patients on anticoagulation medication. The also explored the impact structured prompt guidance LLM's performance.
OBJECTIVE. To determine whether enhanced daily cleaning would reduce contamination of healthcare worker (HCW) gowns and gloves with methicillin-resistant Staphylococcus aureus (MRSA) or multidrug-resistant Acinetobacter baumannii (MDRAB). DESIGN. A cluster-randomized controlled trial. SETTING. Four intensive care units (ICUs) in an urban tertiary hospital. PARTICIPANTs. ICU rooms occupied by patients colonized MRSA MDRAB. INTERVENTION. Extra room surfaces frequently touched HCWs. RESULTS....
SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus, especially if used...
Extreme longevity in humans is known to be a heritable trait. In well-established twin erythrocyte metabolomics and proteomics database, we identified the factor spermidine cluster of correlated molecules with high heritability estimates. Erythrocyte 82% significantly 59 metabolites 22 proteins. Thirty-eight 19 proteins were >20% heritable, mean 61% for 49% Correlated are concentrated energy metabolism, redox homeostasis, autophagy pathways. cell volume (MCV), an established trait, was...