A5100387653- Collagen: Extraction and Characterization
- HER2/EGFR in Cancer Research
- Nanocomposite Films for Food Packaging
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Breast Cancer Treatment Studies
- Advanced Cellulose Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Antimicrobial agents and applications
- Hydrogels: synthesis, properties, applications
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Dyeing and Modifying Textile Fibers
- Cancer Treatment and Pharmacology
- Medical Imaging Techniques and Applications
- Catalysis and Oxidation Reactions
- Advanced Materials and Mechanics
- Monoclonal and Polyclonal Antibodies Research
- Algal biology and biofuel production
- Aquaculture Nutrition and Growth
- Enzyme Production and Characterization
- Ionic liquids properties and applications
Zhengzhou University
2016-2025
Henan Provincial People's Hospital
2017-2025
Henan University
2022-2025
China-US (Henan) Hormel Cancer Institute
2020-2024
Karolinska Institutet
2024
Yanshan University
2024
State Key Laboratory of Metastable Materials Science and Technology
2024
Henan University of Science and Technology
2021-2024
Zhongkai University of Agriculture and Engineering
2017-2024
Northeastern University
2024
The aim of this study was to develop a novel ultrathin fibrous membrane with core-sheath structure as an antioxidant food packaging membrane. prepared by coaxial electrospinning, and the release active substances regulated its special structure. Ferulic acid (FA) incorporated into electrospun zein/polyethylene oxide fibers ensure their synergistic properties. We found that had good morphology smooth surface. internal stable, three materials we used were compatible. For different loading...
Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Cytokine storm syndrome (CSS) can lead acute respiratory distress (ARDS), which contributes most mortalities. Research points interleukin 6 (IL-6) as crucial signature of the cytokine storm, and clinical use IL-6 inhibitor tocilizumab shows potential treatment patient. In this study, we challenged wild-type adenovirus-5/human angiotensin-converting enzyme...
The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clinical stage make development new P-gp challenging and desirable. In this study, we reported our structure-activity relationship studies 4-indolyl quinazoline, which led to discovery a highly effective orally active inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) paclitaxel colchicine in SW620/AD300 HEK293T-ABCB1 cells. bound directly P-gp, did not alter expression or subcellular localization cells,...
Abstract Delivery and sustained release of toothpaste actives is an important but unexplored area. In this work, chitosan nanoparticles were prepared by a water‐in‐oil emulsion/glutaraldehyde crosslinking method. The typical number average diameter active (cetylpyridiniumchloride NaF) was within the range 100–500 nm. particles increased their size at higher pH value. morphology, adherence, stability these investigated scanning electron microscopy, transmission X‐ray photoelectron...
JAK2/STAT3/MYC axis is dysregulated in nearly 70 % of human cancers, but targeting this pathway therapeutically remains a big challenge cancer therapy. In study, genes associated with JAK2, STAT3, and MYC were analyzed, potential target selected. Leucine-rich PPR motif-containing protein (LRPPRC) whose function regulation are not fully understood, emerged as one top 3 terms RNA epigenetic modification. Here, we demonstrate LRPPRC may be an independent prognostic indicator besides MYC....
Background There is accumulating evidence support human epidermal growth factor receptor 2 ( HER2 )-low as a biologically distinct subtype of breast cancer. The present study was conducted to explore whether -low expression will affect the clinical efficacy cyclin-dependent kinase CDK ) 4/6 inhibitor for patients with hormone (HR)-positive, HER-2 negative metastatic Methods Patients HR+/ - cancer who were treated palbociclib from January 2019 June 2021 retrospectively analyzed based on...
The present study aimed to evaluate the clinicopathological characteristics and value of HER2-low expression evolution in breast cancer receiving neoadjuvant chemotherapy (NAC).
The present study aimed to evaluate the predictive factors that predict outcomes of HER2-low breast cancer patients who did not achieve pathological complete response(pCR) after neoadjuvant chemotherapy (NAC). This included with received NAC from January 2017 December 2020. Analysis clinicopathological features, response and outcome were retrospectively analyzed. Univariate multivariable Cox analysis used determine exhibit pCR. 293 Asian included. proportion hormone receptor (HR) positive...